Adler, Kenneth, PhD
Professor

Ph.D.: University of Vermont
Post-doctoral: University of Vermont

Phone: (919) 513-1348
Fax: (919) 515-4237
E-mail: kenneth_adler@ncsu.edu

Research Area:

Research in this laboratory is directed toward elucidating pathogenic mechanisms associated with inflammation in the respiratory airways as seen in asthma, cystic fibrosis and chronic bronchitis. Specific areas of airway pathophysiology include signal transduction pathways that regulate production and secretion of respiratory mucus at the gene and protein levels. The work is done utilizing primary cultures of differentiated human tracheobronchial cells maintained in a unique air-liquid interface, a procedure developed in this laboratory that maintains these cells so they are essentially identical in structure and function to these cells in the body. This research is funded by NIH and several pharmaceutical firms.

Selected Publications:

Agrawal A, Rengarajan S, Adler KB, Ram A, Ghosh B, Fahim M, Dickey BF.
Inhibition of mucin secretion with MARCKS-related peptide improves airway obstruction in a mouse model of asthma.
J Appl Physiol. 2007 Jan;102(1):399-405. Epub 2006 Aug 31.


Adler KB, Li Y: Airway epithelium and mucus: Intracellular signaling pathways for gene expression and secretion. Am J Resp Cell Molec Biol 25:397-400, 2001.

Li Y, Martin LD, Spizz G, Adler KB: MARCKS protein is a key molecule regulating mucin secretion by human airway epithelial cells in vitro. J Biol Chem 276:40982-40990, 2001.

Martin LD, Adler KB, Akley NJ, Crews A, Sharova L. Secretion-competent mouse tracheal epithelial cell culture from the genetically altered mouse: pathway analysis vis gene array. Chest. 2002 Mar;121(3 Suppl):79S.

Krunkosky TM, Martin LD, Fischer BM, Voynow JA, Adler KB: Effects of TNFa on expression of ICAM-1 in human airway epithelial cells in vitro. Oxidant mediated pathways of transcription factor activation. Free Radical Biology and Medicine 35: 1158-1167, 2003.

Booth Bw, Newcomb DC, McKane SA, Crews AL, Adler KB, Bonner JC, Martin LD. Proliferation of the airway epithelium in asthma: are inflammatory cells required? Chest. 2003 Mar;123(3 Suppl):384S-5S. Review.

Singer M, Vargaftig BB,Martin LD, Park JJ, Gruber AD, Li Y, Adler KB. A MARCKS-related peptide blocks mucus hypersecretion in a murine model of asthma. Nature Medicine 10:193-196; 2004.

Park JA, He F, Martin LD, Li Y, Chorley BN, Adler KB. Human neutrophil elastase induces hypersecretion of mucin from well-differentiated human bronchial epithelial cells in vitro via a protein kinase C {delta} - mediated mechanism. Am J Pathol. 2005 Sep;167(3):651-61

Chorley BN, Li Y, Fang S, Park JA, Adler KB. (R)-albuterol elicits antiinflammatory effects in human airway epithelial cells via iNOS. Am J respir Cell Mol Biol. 2006 Jan;34(1):119-27.

Brian N Chorley, Anne L Crews, Yuehua Li, Kenneth B Adler, Michael Minnicozzi, and Linda D Martin.Differential Muc2 and Muc5ac secretion by stimulated guinea pig tracheal epithelial cells in vitro. Respiratory Research 7:35; 2006.

Adler KB, Chaudry IH, Ward PA. Better understanding of organ dysfunction requires proteomic involvement. J Proteome Res. 2006 May; 5(5):1060-2. Review.

Adler KB, Bai C, Tang F, Wang X. Epithelial proteomics in multiple organs and tissues: similarities and variations between cells, organs, and diseases. J Proteome Res. 2006 Apr;5(4):743-55. Review.

ParkJ, Fang S, Koyama S, Parikh I, Adler KB. A peptide against the N-terminus of myristoylated alanine-rich C kinase substrate inhibits degranulation of human leukocytes in vitro. Am J Respir Cell Mol Biol. 2006 Jun; 24(6):647-52. Epub 2006 Mar 16.

Park J, Fang S, Adler KB. Regulation of airway mucin secretion by MARCKS protein involves the chaperones heat shock protein 70 and cysteine string protein. Proc. Am Thorac Soc. 2006 Aug;3(6):493.

Hawkins EC, Birkenheuer AJ, Marr HS, Rogala AR, Large EE, Adler KB. Quantification of mucin gene expression in tracheobronchial epithelium of healthy dogs and dogs with chronic bronchitis. Am J Vet Res. 2007 Apr;68(4):435-40.

Links:

Adler Lab Personnel

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