Adler, Kenneth, PhD
Professor

Ph.D.: University of Vermont
Post-doctoral: University of Vermont

Phone: (919) 513-6549
Fax: (919) 513-6465
E-mail: kenneth_adler@ncsu.edu

Research Area:

Research in this laboratory is directed toward elucidating pathogenic mechanisms associated with inflammation in the respiratory airways as seen in asthma, cystic fibrosis and chronic bronchitis. Specific areas of airway pathophysiology include signal transduction pathways that regulate production and secretion of respiratory mucus at the gene and protein levels. The work is done utilizing primary cultures of differentiated human tracheobronchial cells maintained in a unique air-liquid interface, a procedure developed in this laboratory that maintains these cells so they are essentially identical in structure and function to these cells in the body. This research is funded by NIH and several pharmaceutical firms.

Selected Publications:

Adler KB, Li Y: Airway epithelium and mucus: Intracellular signaling pathways for gene expression and secretion. Am J Resp Cell Molec Biol 25:397-400, 2001.

Li Y, Martin LD, Spizz G, Adler KB: MARCKS protein is a key molecule regulating mucin secretion by human airway epithelial cells in vitro. J Biol Chem 276:40982-40990, 2001.

Krunkosky TM, Martin LD, Fischer BM, Voynow JA, Adler KB: Effects of TNFa on expression of ICAM-1 in human airway epithelial cells in vitro. Oxidant mediated pathways of transcription factor activation. Free Radical Biology and Medicine 35: 1158-1167, 2003.

Singer M, Vargaftig BB,Martin LD, Park JJ, Gruber AD, Li Y, Adler KB. A MARCKS-related peptide blocks mucus hypersecretion in a murine model of asthma. Nature Medicine 10:193-196; 2004.


Links:

Adler Lab Personnel

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