Altier, Craig
Assistant Professor

Phone: (919) 513-6274
Fax: (919) 513-6455
E-mail: craig_altier@ncsu.edu










Research Area:

Work in my laboratory focuses on two areas: molecular characterization of multi-drug resistant Salmonellae, and the regulation of Salmonella typhimurium invasion gene expression. To study antimicrobial resistance, we are characterizing at the molecular level resistance determinants of Salmonellae obtained from food-producing animals and investigating the epidemiology of these multiresistant strains. Through this work, we seek to better understand the origins, transfer, and dissemination of resistance factors among Salmonellae in the animal production environment. We also study the regulation of Salmonella invasion genes encoded by the type III secretion system of Salmonella pathogenicity island I (SPI1). We are currently investigating post-transcriptional regulation of SPI1 genes by CsrA and its RNA modulator CsrB.

Selected Publications:

Altier, C. and M. Suyemoto. (1999) A recombinase-based selection of differentially expressed bacterial genes. Gene 240: 99-106.

Altier, C., M. Suyemoto, A.I. Ruiz, K.D. Burnham, and R. Maurer. (2000) Characterization of two novel regulatory genes affecting Salmonella invasion gene expression. Mol Microbiol 35: 635-646.

Riddle, C., C.L. Lemons, M.G. Papich, and C. Altier. (2000) Evaluation of ciprofloxacin as a representative for veterinary fluoroquinolones in susceptibility testing. J Clin Micro 38: 1636-1637.

Altier, C., M. Suyemoto, and S.D. Lawhon. (2000) Regulation of Salmonella enterica serovar Typhimurium invasion genes by csrA. Infect Immun 68: 6790-6797.

Gebreyes, W.A., P. R. Davies, W.E. Morrow, J. A. Funk , and C. Altier. (2000) Antimicrobial Resistance of Salmonella Isolated from Swine. J Clin Microbiol 38: 4633-4636.

Links:

Altier Lab

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