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Cullen, John
Professor
Phone: 919 513 6350
FAX: 919 513 6455
E-mail: john_cullen@ncsu.edu
 Current Research:
Research in my laboratory is directed towards liver disease with an emphasis on animal models of hepatitis B virus. Animal models are used to assess the efficacy of novel antiviral agents to reduce viral replication to affect the pathologic effects of persistant viral infection. In vivo and in vitro studies using woodchucks, ducks and transgenic mice are involved in our study of the pathogenesis of persistent infection and hepatocelluar carcinoma formation. Currently, our lab is funded primarily by pharmaceutical companies.
Recent Publications:
2001 Zhu, Y., Yamamoto, T., Cullen, J., Saputelli, J., Aldrich C.E., Miller, D.S., Litwin, S., Furman, P.A., Jilbert, A.R., Mason, W.S. Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis. J Virol, 75:311-322.
2000 Ohashi, K, Marion, P.L., Nakai, H., Meuse, L., Cullen, J.M., Bordier, B.B., Schwall, R., Greenberg, H.B., Glenn, J.S., Kay, M.A., Sustained survival of human hepatocytes in mice: A model for in vivo infection with human hepatitis B and hepatitis D viruses. Nature Med, 6:327-333.
2000 Li, D.H.,Brown, C., Havel.E., Cullen, J.M., Woodchuck lymphotoxin alpha, beta and tumor necrosis factor genes; Structure, characterization and biological activity. Gene, 242:295-305.
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