Fuller, Frederick, PhD
Professor

Ph.D., University of Connecticut, Microbiology, 1980
M.S., University of Connecticut, Microbiology, 1977
B.A., University of Connecticut, Zoology, 1975

Phone: 919 515 7396
FAX: 919 515 4237
E-mail: fred_fuller@ncsu.edu

Expertise and Research Interests

My research training and interests are in the field of molecular animal virology. I am particularly interested in understanding the pathogenesis of viral diseases. My research is currently directed toward understanding the molecular basis of the disease process caused by equine infectious anemia virus (EIAV). This virus is a retrovirus in the lentivirus subgroup. The disease is characterized by a persistent, life-long, viral infection that can result in chronic disease characterized by weight loss, anemiaand glomerular nephritis or an acute disease characterized by very high fever, thrombocytopenia, petechiation on mucosal surfaces and edema. The acute clinical signs are directly correlated with increased virus activity in the blood. My group at NCSU incollaboration with Susan Payne at U. of Texas at Arlington have isolated and begun to characterize molecular clones of a highly virulent Wyoming strain of EIAV. We have succeeded in isolating two independent molecular clones of EIAV that yield infectiousvirus upon transfection of susceptible cells that promptly induce the typical clinical signs of EIA in ponies. This system has allowed us to begin to ask very basic questions about the importance of specific viral genes and controlling regions that are necessary for disease induction. We are particularly interested in the role of the EIAV accessory/regulatory genes (tat, rev, S2, dUTPase, p20) in the disease process.

Other Expertise

Academic Experience:Graduated cum laude from the University of Connecticut, 1975National Institute of Health Pre-Doctoral Fellowship, 1977-1980Phi Kappa Phi National Honor SocietyPhi Zeta National Veterinary Honor SocietySmithKline Beecham award for research excellence 1993

Languages

Scale: 1 (basic) to 3 (fluent)
Reading, Writing, Speaking:
French : (2, 2, 1)

Memberships

American Association for the Advancement of Science
American Society for Microbiology
American Society for Virology

Previous Positions

1983-1996, Assistant Professor to Professor, North Carolina State University, College of Veterinary Medicine
1980-1982, Post-doctoral Fellow, University of Alabama at Birmingham
1977- Microbiologist, Connecticut State Department of Health
1975-1980, Graduate Research Assistant, University of Connecticut

Funding Received

National Institutes of Health (NIH): Lentiviral Diseases: EIAV Pathogenesis, $433,698, from 01/01/97 to 12/31/00.

Publications

Russell KE, Perkins PC, Hoffman MR, Miller RT, Walker KM, Fuller FJ, Sellon DC. Platelets from thrombocytopenic ponies acutely infected with equine infectious anemia virus are activated in vivo and hypofunctional. Virology. 259(1): 7-19, Jun 1999 [Abstract]

Breslin JJ, Smith LG, Fuller FJ, Guy JS. Sequence analysis of the matrix/nucleocapsid gene region of turkey coronavirus. Intervirology. 42(1): 22-9, 1999 [Abstract]

Breslin JJ; Smith LG; Fuller FJ; Guy JS. Sequence analysis of the matrix/nucleocapsid gene region of turkey coronavirus.. Intervirology. 42(1): 22-9, 1999 [Abstract]

Payne S L;Qi X M;Shao H;Dwyer A;Fuller F J. Disease induction by virus derived from molecular clones of equine infectious anemia virus.. Journal of Virology. 72(1): 483-7, Jan 1998 [Abstract]

Shao H;Robek M D;Threadgill D S;Mankowski L S;Cameron C E;Fuller F J;Payne S L. Characterization and mutational studies of equine infectious anemia virus dUTPase. Biochimica Et Biophysica Acta. 1339(2): 181-91, 23 May 1997 [Abstract]

Fuller F J. Genes controlling retroviral virulence.. Advances In Veterinary Medicine. 40: 135-55, 1997 [Abstract]

Sellon D C;Walker K M;Russell K E;Perry S T;Fuller F J. Phorbol ester stimulation of equine macrophage cultures alters expression of equine infectious anemia virus. Veterinary Microbiology. 52(3-4): 209-21, Oct 1996 [Abstract]

Sellon D C;Walker K M;Russell K E;Perry S T;Covington P;Fuller F J. Equine infectious anemia virus replication is upregulated during differentiation of blood monocytes from acutely infected horses. Journal of Virology. 70(1): 590-4, Jan 1996 [Abstract]

Steagall W K;Robek M D;Perry S T;Fuller F J;Payne S L. Incorporation of uracil into viral DNA correlates with reduced replication of EIAV in macrophages.. Virology. 210(2): 302-13, 10 Jul 1995 [Abstract]

Brown T T Jr;Shin K O;Fuller F J. Detection of pseudorabies viral DNA in tonsillar epithelial cells of latently infected pigs.. American Journal of Veterinary Research. 56(5): 587-94, May 1995 [Abstract]

Sellon DC; Fuller FJ; McGuire TC. The immunopathogenesis of equine infectious anemia virus.. Virus Res. 32(2): 111-38, 1994 [Abstract]

Payne S L;Rausch J;Rushlow K;Montelaro R C;Issel C;Flaherty M;Perry S;Sellon D;Fuller F. Characterization of infectious molecular clones of equine infectious anaemia virus.. Journal of General Virology. 75 ( Pt 2): 425-9, Feb 1994 [Abstract]

Sellon, D.C., Fuller, F.J., and McGuire, T.C.. The immunopathogenesis of equine infectious anemia virus, Comparative Pathobiology of Lentivirus Infections, Virus Research. Elsevier Sciences Publishers BV (Biomedical Division). 32: 111-138, 1994

Threadgill D S;Steagall W K;Flaherty M T;Fuller F J;Perry S T;Rushlow K E;Le Grice S F;Payne S L. Characterization of equine infectious anemia virus dUTPase: growth properties of a dUTPase-deficient mutant.. Journal of Virology. 67(5): 2592-600, May 1993 [Abstract]

Sellon D C;Cullen J M;Whetter L E;Gebhard D H;Coggins L;Fuller F J. Production and characterization of a monoclonal antibody recognizing a cytoplasmic antigen of equine mononuclear phagocytes.. Veterinary Immunology and Immunopathology. 36(4): 303-18, May 1993 [Abstract]

Clay W C;Fuller F J. Nucleotide sequence of the tick-borne orthomyxo-like Dhori/India/1313/61 virus membrane protein gene.. Journal of General Virology. 73 ( Pt 10): 2609-16, Oct 1992 [Abstract]

Sellon D C;Perry S T;Coggins L;Fuller F J. Wild-type equine infectious anemia virus replicates in vivo predominantly in tissue macrophages, not in peripheral blood monocytes.. Journal of Virology. 66(10): 5906-13, Oct 1992 [Abstract]

Perry S T;Flaherty M T;Kelley M J;Clabough D L;Tronick S R;Coggins L;Whetter L;Lengel C R;Fuller F. The surface envelope protein gene region of equine infectious anemia virus is not an important determinant of tropism in vitro.. Journal of Virology. 66(7): 4085-97, Jul 1992 [Abstract]

Clabough D L;Gebhard D;Flaherty M T;Whetter L E;Perry S T;Coggins L;Fuller F J. Immune-mediated thrombocytopenia in horses infected with equine infectious anemia virus.. Journal of Virology. 65(11): 6242-51, Nov 1991 [Abstract]

Lin D A;Roychoudhury S;Palese P;Clay W C;Fuller F J. Evolutionary relatedness of the predicted gene product of RNA segment 2 of the tick-borne Dhori virus and the PB1 polymerase gene of influenza viruses.. Virology. 182(1): 1-7, May 1991 [Abstract]

Whetter L;Archambault D;Perry S;Gazit A;Coggins L;Yaniv A;Clabough D;Dahlberg J;Fuller F;Tronick S. Equine infectious anemia virus derived from a molecular clone persistently infects horses.. Journal of Virology. 64(12): 5750-6, Dec 1990 [Abstract]

Freedman-Faulstich E Z;Fuller F J. Nucleotide sequence of the tick-borne, orthomyxo-like Dhori/Indian/1313/61 virus envelope gene.. Virology. 175(1): 10-8, Mar 1990 [Abstract]

Richards RG, MacLachlan NJ, Heidner HW, Fuller FJ. Comparison of virologic and serologic responses of lambs and calves infected with bluetongue virus serotype 10. Veterinary Microbiology. 18(3-4): 233-42, Dec 1988 [Abstract]

Heidner HW, MacLachlan NJ, Fuller FJ, Richards RG, Whetter LE. Bluetongue virus genome remains stable throughout prolonged infection of cattle. Journal of General Virology. 69 ( Pt 10): 2629-36, Oct 1988 [Abstract]

Schaper UM, Fuller FJ, Ward MD, Mehrotra Y, Stone HO, Stripp BR, De Buysscher EV. Nucleotide sequence of the envelope protein genes of a highly virulent, neurotropic strain of Newcastle disease virus. Virology. 165(1): 291-5, Jul 1988 [Abstract]

Fuller FJ, Freedman-Faulstich EZ, Barnes JA. Complete nucleotide sequence of the tick-borne, orthomyxo-like Dhori/Indian/1313/61 virus nucleoprotein gene. Virology. 160(1): 81-7, Sep 1987 [Abstract]

MacLachlan NJ, Heidner HW, Fuller FJ. Humoral immune response of calves to bluetongue virus infection. American Journal of Veterinary Research. 48(7): 1031-5, Jul 1987 [Abstract]

Simmons DG, Rose LP, Fuller FJ, Maurer LC, Luginbuhl GH. Turkey coryza: lack of correlation between plasmids and pathogenicity of Bordetella avium. Avian Diseases. 30(3): 593-7, 1986 [Abstract]

Davis NL, Fuller FJ, Dougherty WG, Olmsted RA, Johnston RE. A single nucleotide change in the E2 glycoprotein gene of Sindbis virus affects penetration rate in cell culture and virulence in neonatal mice. Proceedings of the National Academy of Sciences of the United States of America. 83(18): 6771-5, Sep 1986 [Abstract]

MacLachlan NJ, Fuller FJ. Genetic stability in calves of a single strain of bluetongue virus. American Journal of Veterinary Research. 47(4): 762-4, Apr 1986 [Abstract]

Bishop DH, Fuller FJ, Akashi H. Coding assignments of the RNA genome segments of California serogroup viruses. Progress in Clinical and Biological Research. 123: 107-17, 1983 [Abstract]

Collins PL, Fuller FJ, Marcus PI, Hightower LE, Ball LA. Synthesis and processing of Sindbis virus nonstructural proteins in vitro. Virology. 118(2): 363-79, Apr 1982 [Abstract]

Fuller FJ, Marcus PI. Sindbis virus. I. Gene order of translation in vivo. Virology. 107(2): 441-51, Dec 1980 [Abstract]

Fuller FJ, Marcus PI. Interferon induction by viruses. Sindbis virus: defective-interfering particles temperature-sensitive for interferon induction. Journal of General Virology. 48(Pt 2): 391-4, Jun 1980 [Abstract]

Fuller FJ, Marcus PI. Interferon induction by viruses. IV. Sindbis virus: early passage defective-interfering particles induce interferon. Journal of General Virology. 48(1): 63-73, May 1980 [Abstract]

Marcus PI, Fuller FJ. Interferon induction by viruses. II. Sindbis virus: interferon induction requires one-quarter of the genome--genes G and A. Journal of General Virology. 44(1): 169-77, Jul 1979 [Abstract]

Fuller FJ, Marcus PI. Cell surface-associated ribonuclease activities. Journal of Cellular Physiology. 98(1): 1-10, Jan 1979 [Abstract]
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