Hauck, Marlene, DVM, PhD, DACVIM (Oncology)
Assistant Professor

D.V.M.: Colorado State University
Ph.D.: Duke University
Residency: North Carolina State University

Phone: (919) 513-6272
Fax: (919) 513-6336
E-mail: marlene_hauck@ncsu.edu

Research Area:

My research is primarily focused on the development and optimization of targeted therapeutic agents for cancer and novel methods to improve delivery of therapeutics, such as hyperthermia. Much of this work is done in collaboration with researchers at Duke University and within the North Carolina Animal Cancer Treatment Program at the College of Veterinary Medicine. Current projects focus on the development of vascularly-targeted peptides, optimization of tumor-targeted mAb/hyperthermia protocols and phase I clinical trials evaluating hyperthermia as a means of improving liposome encapsulated drug delivery and as a means of controlling gene expression with gene therapy. Funding for this research has included the NIH/NCI, DOE and pharmaceutical companies.

Selected Publications:

Case, BC, Hauck, ML, Yeager, RL, Simkins, AH, De Serres, M, Schmith, VD, Dillberger, JE and Page, RL. The pharmacokinetics and pharmacodynamics of GW395058, a peptide agonist of the thrombopoietin receptor, in the dog, a large-animal model of chemotherapy-induced thrombocytopenia. Stem cells, 2000, 18(5):360-365.

Hauck ML, Zalutsky MR. The effects of local hyperthermia on the catabolism of a radioiodinated chimeric monoclonal antibody. Clinical Cancer Research 1998; 4: 2071-2077.

Hauck ML, Larsen RH, Welsh PC, Zalutsky MR. Cytotoxicity of a-particle emitting 211At-labeled monoclonal antibody in tumor spheroids: effect of moderate hyperthermia. British Journal of Cancer 1998;77:753-759.

Hauck ML, Coffin DO, Dodge RK, Dewhirst MW, Mitchell JB, Zalutsky MR. Hyperthermia does not effect tumor interstitial fluid pressure in a human glioma xenograft model. International Journal of Hyperthermia 1997;13:307-316.

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