1982-1988 Assistant Professor of Aquatic Medicine, NCSU
1988-1994 Associate Professor of Aquatic Medicine, NCSU
1994-present Professor of Aquatic Medicine, NCSU

Research Area:

Our laboratory studies infectious diseases of finfish and shellfish, with emphasis on immune mechanisms and how these are influenced by environment and toxins. A major thrust of this research is the identification of novel, innate, antimicrobial defenses (polypeptide antibiotics) in fish and shellfish. These novel compounds are being examined for use in both disease management in aquatic animals as well as possible therapeutics in other species (e.g., humans). Another aspect of our research involves ecotoxicology and stress, with emphasis on the development of biomarkers for monitoring the health of cultured and wild aquatic populations. We are also involved in the development of molecular tools for the identification of important aquaculture pathogens. Funding is provided by North Carolina Sea Grant, the Binational Israel-U.S. Agricultural Research and Development Fund, the U.S.D.A.-N.R.I. and miscellaneous other funding sources.

Selected Publications (49 of 130):

Vandersea, M.W., R.W. Litaker, B. Yonnish, E. Sosa, J.H. Landsberg, C. Pullinger, P. Moon Butzin, J. Green, J.A. Morris, H. Kator, E.J. Noga, and P.A. Tester. 2006. Molecular assays for detecting Aphanomyces invadans in ulcerative mycotic fish lesions. Applied and Environmental Microbiology 72:1551-1557.
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Noga E.J. and M.G. Levy. 2006. Phylum Dinoflagellata. In: Fish Diseases and Disorders, Volume 1: Protozoan and Metazoan Infections, PTK Woo (Ed.), 2nd edition, CABI International, Oxford, pp. 16-45.

Callahan, H.C., R.W. Litaker and E.J. Noga. 2005. Genetic relationships among members of the Ichthyobodo necator Complex (INC): Implications for the management of aquaculture stocks. Journal of Fish Diseases 28:111-118.
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Udomkusonsri, P. and E.J. Noga. 2005. The Acute Ulceration Response (AUR): A potentially widespread and serious cause of skin infections in fish. Aquaculture 246:63-77.
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Lewbart, G.A., D. Butkus, M. Papich, A.K. Coleman, H.N. Krum and E.J. Noga. 2005. Evaluation of a method for intracoelomic catheterization in koi. JAVMA 226:784-788.
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Huh M.-D., C. Thomas, P. Udomkusonsri and E.J. Noga. 2005. Epidemic trichodinosis associated with severe epidermal hyperplasia in feral largemouth bass from North Carolina, USA. Journal of Wildlife Diseases 41:647-653.

Seo, J.-K., J.M. Crawford, K.L. Stone and E.J. Noga. 2005. Purification of a novel arthropod defensin from the American oyster, Crassostrea virginica. Biochemical and Biophysical Research Communications 338:1998-2004.
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Chinchar V.G., L. Bryan, U. Silphadaung, E. Noga, D. Wade and L. Rollins Smith. 2004. Inactivation of viruses infecting ectothermic animals by amphibian and piscine antimicrobial peptides. Virology 323:268-275.
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Udomkusonsri, P., E.J. Noga and N. Monteiro-Riviere. 2004. Pathogenesis of the Acute Ulceration Response (AUR) in hybrid striped bass. Diseases of Aquatic Organisms 61:199-213.
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Adams, S.M., M.S. Greeley, J. M. Law, E.J. Noga, and J.T. Zelikoff. 2003. Application of multiple sublethal stress indicators to assess the health of fish in Pamlico Sound following extensive flooding. Estuaries 26:1365-1382.

Cowen, P., D.E. Hansen, C.L. Hofacre, E.J. Noga, D.G. Pyburn and A. Gebreyes Wondwossen. 2003. Food animal industry activities in food safety. In: M.E. Torrence and R.E. Isaacson (eds.), Microbial Food Safety in Animal Agriculture: Current Topics. Iowa State Press, Ames, IA, pp. 19-25.

Noga E.J. and U. Silphaduang, U. 2003. Piscidins: A novel family of peptide antibiotics from fish. Drug News and Perspectives 16:87 92.
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Callahan, H.C., R.W. Litaker and E.J. Noga. 2002. Molecular taxonomy of the Suborder Bodonina (Order Kinetoplastida), including the important fish parasite Ichthyobodo necator. Journal of Eukaryotic Microbiology 49:119-128.
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Litaker R.W., M.W. Vandersea, S.R. Kibler, V.J. Madden, E.J. Noga and P.A. Tester. 2002. Life cycle of the heterotrophic dinoflagellate Pfiesteria piscicida. Journal of Phycology 38:442-463
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Callahan, H.C. and E.J. Noga. 2002. Tricaine dramatically reduces the ability to diagnose protozoan ectoparasite (Ichthyobodo necator) infections. Journal of Fish Diseases 25:433-437.
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Noga E.J. and P. Udomkusonsri. 2002. Fluorescein: A rapid, sensitive, nonlethal method for detecting skin ulceration in fish. Veterinary Pathology 39:726-731.
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Noga E.J., Z. Fan and U. Silphaduang. 2002. Host site of activity and cytological effects of histone-like proteins against the parasitic dinoflagellate Amyloodinium ocellatum. Diseases of Aquatic Organisms 52:207-215.
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Litaker R.W., M.W. Vandersea, S.R. Kibler, E.J. Noga and P.A. Tester. 2002. Reply to comment on the life cycle and toxicity of Pfiesteria piscicida revisited. Journal of Phycology 38:1268-1272.

Silphaduang, U. and E.J. Noga. 2001. Peptide antibiotics in mast cells of fish. Nature 414:268-269.
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Robinette, D.R. and E.J. Noga. 2001. Histone-Like Protein (HLP): A novel method for assessing chronic stress in fish. Diseases of Aquatic Organisms 44:97-107.
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Noga E.J., Z. Fan and U. Silphaduang. 2001. Histone-like proteins from fish are lethal to the parasitic dinoflagellate Amyloodinium ocellatum. Parasitology 123:57-65.
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Noga E.J. 2000. Hemolymph biomarkers of crustacean health. In: M. Fingerman and R. Nagabhushanam (eds.), Recent Advances in Marine Biotechnology, Vol. 5 Immunobiology and Pathology. Science Publishers, Inc., Enfield, New Hampshire, pp. 125-163.

Noga E.J. 2000. Skin ulcers in fish: Pfiesteria and other etiologies. Toxicological Pathology 28:807-823.

Noga E.J., R. Smolowitz and L. Khoo. 2000. Pathology of shell disease in the blue crab, Callinectes sapidus. Journal of Fish Diseases 23:389-399.
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Silphaduang, U., K. Hatai, S. Wada and E.J. Noga. 2000. Cladosporium infection in tomato clownfish. Journal of Zoo and Wildlife Medicine 31:259-261.
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Kane, A.S., M.J. Dykstra, E.J. Noga, R. Reimschuessel, A. Baya, C. Driscoll, H.W. Paerl and J. Landsberg. 2000. Etiologies, observations and reporting of estuarine finfish lesions. Marine Environmental Research 50:473-477.
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Khoo, L., D. Robinette and E.J. Noga. 1999. Isolation of callinectin, an antibacterial peptide from blue crab (Callinectes sapidus) hemocytes. Marine Biotechnology 1:44-51.
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Noga E.J., C. Wang, C.B. Grindem and R. Avtalion. 1999. Comparative clinicopathological responses of striped bass and palmetto bass to acute stress. Transactions of the American Fisheries Society 128:680-686.
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Litaker, W., P.Tester, E. Haugen, M. Levy, A. Colorni and E.J. Noga. 1999. The phylogenetic relationship of Pfiesteria piscicida, a Cryptoperidonopsoid sp., Amyloodinium ocellatum and a Pfiesteria-like dinoflagellate to other dinoflagellates and apicomplexans. Journal of Phycology 35:1379-1389.
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Noga E.J., S. Botts, S. Yang and R. Avtalion. 1998. Acute stress causes skin ulceration in striped bass and hybrid bass (Morone). Veterinary Pathology 35:102-107.
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Robinette, D.R., S. Wada, T. Arroll, M.G. Levy, W. Miller and E.J. Noga. 1998. Antimicrobial activity in the skin of the channel catfish Ictalurus punctatus: Characterization of broad-spectrum histone-like antimicrobial proteins. Cellular and Molecular Life Sciences 54:467-475.
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Cobb, C.S., M.G. Levy and E.J. Noga. 1998. Acquired immunity to amyloodiniosis is associated with an antibody response. Diseases of Aquatic Organisms 34:125-133.

Cobb, C.S., M.G. Levy and E.J. Noga. 1998. Development of immunity by the tomato clownfish (Amphiprion frenatus) to the dinoflagellate parasite Amyloodinium ocellatum. Journal of Aquatic Animal Health 10:259-263.
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Noble A.C., R.L. Herman, E.J. Noga and G.L. Bullock. 1997. Description of a recurrent amoebic gill infestation in rainbow trout (Oncorhynchus mykiss) cultured in a semi-closed recirculating system. Journal of Aquatic Animal Health 9:64-69.
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Wang C., E.J. Noga, R. Avtalion and M.G. Levy. 1997. Whole blood assay for examining lymphocyte blastogenesis of percichythyid bass (Morone). Veterinary Immunology and Immunopathology 58:355-362.
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Noga E.J., T.W. Arroll and Z. Fan. 1996. Specificity and some physicochemical characteristics of the antibacterial activity from blue crab Callinectes sapidus. Fish and Shellfish Immunology 6:403-412.
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Noga E.J., L. Khoo, J. Stevens, Z. Fan and J. Burkholder. 1996. Novel toxic dinoflagellate causes epidemic disease in estuarine fish. Marine Pollution Bulletin 32:219-224.
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Noga E.J. 1996. Fish Disease: Diagnosis and Treatment. Iowa State University Press, Ames, IA. 378 p.

Smith, S.A., M.G. Levy and E.J. Noga. 1994. Detection of anti-Amyloodinium ocellatum antibody from cultured hybrid striped bass (Morone saxatilis x Morone chrysops) during an epizootic of amyloodiniosis. Journal of Aquatic Animal Health 6:79-81.
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Smith, S.A., D. Gebhard, J. Housman, M.G. Levy and E.J. Noga. 1993. Isolation, purification and molecular weight characterization of serum immunoglobulin from tilapia (Oreochromis aureus). Journal of Aquatic Animal Health 5:23-35.
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Noga E.J. 1993. Fungal diseases of freshwater fishes: Recent advances. Annual Review of Fish Diseases 3:291-304.
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Burkholder J.M., E.J. Noga, C. Hobbs, H.G. Glasgow, Jr and S.A. Smith. 1992. A new "phantom" dinoflagellate, causative agent of major estuarine fish kills. Nature 358:407-410; 360:768.
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Noga E.J., J.H. Landsberg and S.A. Smith. 1991. Amyloodiniosis in cultured hybrid striped bass (Morone saxatilis x M. chrysops) in North Carolina. Journal of Aquatic Animal Health 3:294-297.
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Levine, J.F., J.H. Hawkins, M.J. Dykstra, E.J. Noga, D.F. Moye and R.S. Cone. 1990. Epidemiology of Atlantic menhaden affected with ulcerative mycosis in the Tar-Pamlico estuary. Journal of Aquatic Animal Health 2:162-171.
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Noga E.J., M.J. Dykstra, and J.F. Wright. 1989. Chronic inflammatory cells with epithelial cell characteristics in teleost fishes. Veterinary Pathology 26:429-437.

Smith, S.A., E.J. Noga and R.A. Bullis. 1988. Mortality in Tilapia aurea due to a toxic dinoflagellate bloom. Proceedings of the Third International Colloquium on Patholology in Marine Aquaculture, pp. 167-168.

Noga E.J. 1987. Propagation in cell culture of the dinoflagellate Amyloodinium, an ectoparasite of marine fishes. Science 236:1302 1304.
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Noga E.J. and J.X. Hartmann. 1981. Establishment of walking catfish (Clarias batrachus) cell lines and development of a channel catfish (Ictalurus punctatus) virus vaccine. Canadian Journal of Fisheries and Aquatic Sciences 38:925 930.

Noga E.J. 1979. Primary tissue cultures from organ fragments: a simplified method. Experientia 35:181 182.

Opportunities:

Graduate Study

Opportunities are periodically available to highly qualified applicants whose interests are within one of our major emphases (see Research Areas).

Prospective students are urged to apply for all fellowships for which they might be eligible:

CVM Graduate Fellowships - Students applying for graduate study are automatically placed in competition for these fellowships.

NCSU Graduate Fellowships
NSF Graduate Research Fellowships
Howard Hughes Medical Institute Fellowships
Ford Foundation Minority Predoctora Fellowships
U.S.E.P.A. STAR Fellowships

Teaching Assistantships, requiring 20 hours per week of effort, are available through the Biological Sciences program

Research Assistantships, requiring 20 hours per week of effort, are also sometimes available

Postdoctoral Research

Postdoctoral researchers are usually supported by grants, or by postdoctoral fellowships awarded to the individual. These postdoctoral fellowships require that the applicant prepare a proposal to submit to the funding agency. Please contact EJ Noga directly prior to the preparation of a proposal.

NSF
NIH
BARD
USDA
Other Postdoctoral

• Noga Lab
• Current Projects

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