Research Cores
Allergic Diseases
This core concentrates on the characterization of spontaneous companion animal allergic diseases. Areas of interest include genetics, molecular and immuunopathological mechanisms and investigation of new preventive and/or treatment modalities. For more information contact the core leader Dr. Thierry Olivry.
Specific areas of research include:
- Genetic linkage of spontaneous atopic dermatitis and/or food allergies in specific breeds or experimental allergic lines.
- Mechanisms of allergen sensitization in an experimental model of allergy.
- Mechanisms of clinical signs development in a canine model of food allergens.
- Mechanisms of IgE-mediated mast cell activation using tissue culture models.
- Relationship of IgE-mediated allergy and renal glomerular lesions in a spontaneous canine model.
- Prevention of spontaneous canine IgE-mediated allergy using innate immune system stimulants.
- Testing of novel therapeutics for allergic airway disease.
Biostatistics
The core concentrates on the development of new statistical methodologies to be applied to scientific research in the areas of medicine, pharmacology, and public health. For more information contact the core leader, Dr. Marie Davidian.
Specific areas of research include:
- Development of statistical methods for the design and analysis of clinical trials.
- Bioinformatics and computational biology.
- Statistical genetics including statistical methods to identify susceptibility genes for complex traits.
- Novel statistical approaches for longitudinal data analysis, survival analysis, and missing data.
Clinical Genomics
This core concentrates on the genetic and epigenetic mechanisms in disease states, and in the identification analysis of spontaneous and induced (transgenic) familial and congenital disorders. Areas of focus includes, cellular genomic basis of familial disorders, the role of the epigenome in congenital/familial abnormalities, and functional genomics through microarrays, bioinformatics, biostatistics, transgenics and molecular therapeutics. For more information contact the core leader Dr. Jorge Piedrahita.
Specific areas of research include:
- Cellular genomic approaches for the study and treatment of congenital and/or familial disorders.
- Development and implementation of gene expression profiling approaches to understand normal and abnormal biological processes.
- Linkage and mapping analysis for studying the genetic basis of inherited disorders.
- Epigenetic and imprinting disregulation effects on abnormal fetal and placental development.
- Development of transgenic animal models of human and animal disease.
- Development of statistical approaches for the utilization of animal models in clinical trials.
- Development of novel therapeutic approaches to genetic diseases.
Emerging and Zoonotic Diseases
This core uses an integrated approach to achieve a better understanding of infectious diseases. Focus areas include molecular pathogenesis, antibiotic resistance, microbial diversity, pathogen detection, therapeutics and vaccines, and the effects of the environment on infectious disease. The goal of this core is to integrate basic and clinical research to investigate infectious diseases of companion and production animals, and to exploit animal models of human disease. For more information contact the core leader Dr. Gregg Dean (acting head).
Specific areas of research include:
- Development of molecular diagnostic tools for bacterial and rickettsial organisms.
- Study of the molecular basis of virulence among bacterial pathogens.
- Improved biosecurity against infectious diseases in production animals.
- Advances in molecular epidemiology for the detection and spread of pathogens.
- Study of the basis and spread of antimicrobial resistance in bacteria.
- Vaccine development.
Mucosal Pathophysiology
This core concentrates on the pathogenetic mechanisms of disease in epithelium lining the respiratory, gastrointestinal, and reproductive tracts. Areas of focus include signal transduction events and molecules related to ion and fluid transport and secretion, interactions of epithelium with extracellular matrix and with inflammatory cells, and mechanisms of epithelial hyperplasia and metaplasia. For more information contact the core leader Dr. Phil Sannes.
Specific areas of research include:
- Mechanisms of exocytotic secretion of mucus in health and disease using in vitro and in vivo approaches, including induced and naturally-occurring animal models.
- Mechanisms of ion and fluid transport across gastrointestinal epithelium in health and disease.
- Mechanisms governing mucosal response to inflammatory and injurious stimuli, including interactions between multiple mucosal cell types and the extracellular matrix.
- Mechanisms of neutrophil adhesion and activation during mucosal compromise.
- Mechanisms of airway epithelial injury, repair and development of goblet cell hyperplasia and metaplasia using in vitro and induced in vivo models of inflammatory airway disease.
- Nutritional determinants of enteric disease states as they relate to mucosal injury and repair.
- Mechanisms of gastrointestinal injury and repair focused on epithelial restitution.
Oncology
The core concentrates on improving the understanding of the pathogenesis and treatment of cancer through collaborative research on induced and spontaneous models of cancer. Areas of focus include cancer genomics, cytogenetics, manipulation of tumor physiology, signaling and cell cycle control/differentiation, clinical diagnosis and treatment. For more information contact the core leader Dr. Jon Horowitz.
Specific areas of research include:
- Cancer genomics/molecular cytogenetics of a variety of cancers of comparative significance (including linkage and mapping analysis, correlation with disease occurrence and outcome).
- Cell signaling/cell cycle control/differentiation.
- Tumor physiology (effects of intervention on physiologic parameters in tumors).
- Development and testing of novel therapeutics and validation of surrogate markers.
- Clinical diagnosis and treatment.