Genetic Investigation of Addison’s Disease in Standard Poodles
Hypoadrenocorticism (Addison’s Disease) is a life-threatening endocrine disease caused by immune-mediated destruction of the adrenal glands in dogs. This disease is common in Standard Poodles, and is strongly suspected to have a genetic basis. Understanding the genetic basis of Addison’s Disease in dogs may lead to a better understanding of the disease mechanism, alteration of breeding practices to reduce the disease prevalence, and a better understanding of this disease in humans.
December 2013-August 2014
A small blood sample for DNA will be collected from dogs with and without the disease. An additional sample is required for the ACTH Stimulation test, although this amount is minimal as well.
- Control Dogs are 10 years of age or greater. Dogs confirmed by normal results on an ACTH stimulation test, regardless of the presence of liver disease, will be enrolled.
- Affected Dogs of any age with a current diagnosis of Addison’s disease will be enrolled.
- A Free ACTH stimulation test will be performed in the event that an animal has not been previously tested for Addison’s disease.
If you have any questions about this study or have a patient (or pet) that may be eligible, please contact the Clinical Studies Core at (919) 513-6384 or (919) 515-2633 or firstname.lastname@example.org.
Page last updated March 05, 2014