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CCTRP Faculty Members:

Staff Members:

  • Jim D. Brooks, MS, Laboratory Supervisor
  • Patty Routh, Research Specialist
  • Jim L. Yeatts, MS, Laboratory Research Specialist/Analytical Chemist

CCTRP Graduate Students/Trainess

  • Daniella Karadzovska, BS, Ph.D candidate
  • Alexcia Linthicum, BS, MS, Ph.D. Student
  • Lindsey Waltman, BS, MS, DVM/Ph.D. candidate

Dr. Nancy Monteiro, Professor of Investigative Dermatology and Toxicology

Dr. Nancy Monteiro-Riviere

College of Veterinary Medicine BOX 8401 4700 Hillsborough St. Raleigh, NC 27606
Phone: (919) 513-6426 ; (919) 513-6323
Fax: (919) 513-6358

Biographical Sketch

Nancy Ann Monteiro-Riviere, Ph.D., ACT, Fellow ATS, is a Professor of Investigative Dermatology and Toxicology in the Center for Chemical Toxicology Research and Pharmacokinetics, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University (NCSU) in Raleigh NC. Dr. Monteiro-Riviere is also a Professor in the NCSU/UNC-CH Biomedical Engineering Faculty as well as being a Research Adjunct Professor in the Department of Dermatology, School of Medicine at the University of North Carolina at Chapel Hill. She received her B.S. in Biology (cum laude) from Stonehill College in North Easton, MA and her M.S. and Ph.D. in Anatomy from Purdue University in West Lafayette, IN. She completed post-doctoral training in Experimental Pathology / Toxicology at the Chemical Industry Institute of Toxicology in Research Triangle Park, NC. She joined the faculty at NCSU in 1984. She is a Diplomat, Board Certified Forensic Examiner and lifetime fellow, and Diplomat, American Board of Forensic Medicine. She is a member of Sigma Xi and Phi Zeta honor societies. Dr. Monteiro-Riviere is Past-President of the Dermatotoxicology Specialty Section, and past-president of the In Vitro Specialty Section of the Society of Toxicology. She is a Fellow in the Academy of Toxicological Sciences and a member of the American College of Toxicology. She presently serves on the NIH Scientific Advisory Committee on Alternative Toxicological Methods (SACATM), USEPA Scientific Advisory Panel-Federal Insecticide, Fungicide and Rodenticide Act (FIFRA), Health and Environmental Sciences Institute Nanomaterial Safety Committee, International Life Sciences Institute (ILSI) Risk Sciences Institute Nanomaterial Toxicity Screening Working Group, Chair of the Board of Publications of the National Society of Toxicology and Editorial Boards of the Journal of Applied Toxicology, Journal of Toxicology-Cutaneous and Ocular, Toxicology In Vitro, and Toxicology Mechanisms and Methods and Associate Editor of Nanomedicine and Interdisciplinary Reviews. Dr. Monteiro-Riviere has published more than 180 publications, holds a US patent, and has been the recipient of 9.5 million dollars in extramural research support from various government and private sources. Her research interests relate to chemical absorption, drug delivery and mechanisms of chemical irritation to skin. Current research focuses on the impact of manufactured nanomaterials on human health and the environment. This research begins to assess the nature of interaction between manufactured nanoparticles and the skin; including dermal absorption, cutaneous toxicity as well as the ability to distribute to the skin after systemic exposure. These studies include iron oxide particles, quantum dots, multi-walled and single-walled carbon nanotubes and fullerene nanoparticles which are representatives of the broad spectrum of nanoparticles presently being used by industry and found in some consumer products. This research will define the boundaries of a dermal risk assessment for manufactured nanoparticle exposure.

Research Interests

Dr. Monteiro's research focuses on human occupational exposure by assessing chemical interactions and toxicity of environmental and novel pharmaceutical compounds and engineered nanomaterials. This involves assessing dermatotoxicity and absorption in both in vivo and in vitro model systems. Primarily, pig skin is used as a model because it is similar anatomically, physiologically and biochemically to human skin. These similarities play an important role in assessing the absorption of many compounds. Also, she is involved with integrating compound exposure with absorption to assess how chemical interactions with keratinocytes modify toxicity to the skin. She has been particularly interested in assessing the mechanism behind how multiple chemical exposures modulates interaction of a single chemical with keratinocytes and the interaction between nanomaterials. Skin function is assessed by studying proinflammatory cytokines using RT-PCR and changes in keratinocyte proteins using proteomics. An important interaction that is unique to chemical exposure to skin is the interaction that occurs with the lipids in the stratum corneum barrier. These have been explored using Fourier Transform Infra Red (FTIR) imaging as well as transmission and scanning electron microscopy. Model systems employed include human epidermal keratinocyte cell cultures as well as a unique perfused skin model developed in our Center that has been validated to be predictive of human absorption. She is fascinated by those problems involving exposure to skin of chemicals that modulates their subsequent absorption or activity either through changes induced in the stratum corneum lipid barrier or keratinocyte proteome. Current research relates to the impact of manufactured nanomaterials on human health and the environment. In addition, she has studied the mechanism of skin toxicity when model drugs are delivered by iontophoresis or electroporation, investigating how physical changes in membrane function or absorption pathways induced by electrical currents modify chemical interactions with membrane and cellular targets. Recently, she has applied these techniques to investigating the interaction of multi-walled carbon nanotubes with human keratinocytes. Exposure must be evaluated before the risk of this hazard can be determined in an occupational or environmental scenario. These findings suggest that the toxicology of these structures must be assessed before widespread public exposure so that appropriate protective measures can be developed.

Selected Publications

Selected Publications:

Riviere JE, Inman AO, Monteiro-Riviere NA. Absorption, Penetration and Cutaneous Toxicity of Jet Fuels and Hydrocarbons Components. In Jet Fuel Toxicology  (Witten ML, Zeiger E, Ritchie GD, eds). CRC Press, Boca Raton, Fl, Chapter 7, 119-134, 2010.  

Xia XR, Monteiro-Riviere NA, Riviere JE. An index for characterization of nanomaterials in biological systems. Nature Nanotechnology. 5(9):671-675, 2010.

Basak SC, Gute BD, Monteiro-Riviere NA, Witzmann FA: Characterization of Toxicoproteomics Maps for Chemical Mixtures using Information Theoretic Approach. In Principles and Practice of Mixtures Toxicity (Mumtaz MM, ed). Wiley-VCH Weinheim, Chapter 8, 215-234, 2010.   

Doraiswany A, Ovsianikov A, Gittard SD, Monteiro-Riviere NA, Crombez R, Montalvo E, Shen W, Cichkov BN, Narayan RJ. Fabrication of microneedles using two-photon polymerization for transdermal delivery of nanomaterials. Journal of Nanoscience and Nanotechnology 10:6305-6312, 2010.

Narayan RJ, Adiga SP, Pellin MJ, Curtiss LA, Stafslien S, Chisholm B, Monteiro-Riviere NA, Brigmon RL, Elam JW. Atomic layer deposition of nanoporous biomaterials. Materials Today 13:60-64, 2010.

Gittard SD, Ovsianikov A, Akar H, Chichkov BN, Monteiro-Riviere NA, Stafslien S, Chilsholm B, Shih CC, Shih CM, LinSJ, SuYY, Narayan RJ. Two-photon polymerization-micromolding of polyethylene glycol-gentamicin sulfate microneedles. Advanced Engineering Biomaterials 12(4):B77-B82, 2010.

Riviere JE, Monteiro-Riviere NA. Toxicokinetics: Dermal Exposure and Absorption of Chemicals and Nanomaterials. In Comprehensive Toxicology, 2nd Ed. (McQueen C, ed). Elsevier, NY, Vol. 1. Chapter 1.05:111-122, 2010.

Xia XR, Monteiro-Riviere NA, Riviere JE. Intrinsic biological property of colloidal fullerene nanoparticles (nC60): lack of lethality after high dose exposure to human epidermal and bacterial cells. Toxicology Letters 197(2):128-134, 2010.

Leavens TL, Xia XR, Lee HA, Monteiro-Riviere NA, Brooks JD, Riviere JE. Evaluation of perfused porcine skin as a model system to quantitate tissue distribution of fullerene nanoparticles. Toxicology Letters 197(1):1-6, 2010.

Haslauer CM, Springer J, Harrysson OLA, Loboa EG, Monteiro-Riviere NA, Marcellin-Little DJ. In vitro biocompatibility of titanium alloy discs made using direct metal fabrication. Medical Engineering and Physics 32:645-652, 2010.

Monteiro-Riviere NA, Oldenburg SJ, Inman AO. Interactions of aluminum nanoparticles with human epidermal keratinocytes. Journal of Applied  Toxicology 30:276-285, 2010.

Narayan RJ,  Adiga SP, Pellin MJ, Curtiss LA, Hryn AJ, Stafslien S, Chisholm B, Shih CC, Shih CM, Lin SJ, Su YY, Jin C, Zhang J, Monteiro-Riviere NA, Elam JW. Atomic layer deposition-based functionalization of materials for medical and environmental health applications. Philosophical Transactions of The Royal Society A Mathematical, Physical & Engineering Sciences 368:2033-2064, 2010. 

Grissom RE, Abernathy CO, Monteiro-Riviere NA. Potential Arsenic Exposure Through Dermal Penetration. In Toxicology of the Skin-Target Organ Series Monteiro-Riviere NA (ed.) Informa Healthcare, New York, NY, Vol. 29, Chapter 23, 347-360, 2010.

Monteiro-Riviere NA, Baroli B.  Nanomaterial Penetration.  In Toxicology of the Skin-Target Organ Series. Monteiro-Riviere NA (ed.) Informa Healthcare, New York, NY, Vol. 29, Chapter 22, 333-346, 2010.

Monteiro-Riviere NA. Structure and Function of Skin. In Toxicology of the Skin-Target Organ Series.  Monteiro-Riviere NA (ed.) Informa Healthcare, New York, NY, Vol. 29, Chapter 1, 1-18, 2010.

Samberg ME, Oldenburg SJ, Monteiro-Riviere NA. Evaluation of silver nanoparticle toxicity in vivo skin and in vitro keratinocytes. Environmental Health Perspectives 118:407-413, 2010.

Zhang LW, Monteiro-Riviere NA. Lectins modulate multi-walled carbon nanotubes cellular uptake in human epidermal keratinocytes. Toxicology In Vitro 24:546-551, 2010.

Xia XR, Monteiro-Riviere NA, Riviere JE.  Skin penetration and kinetics of pristine fullerenes (C60) topically exposed in industrial organic solvents. Toxicol Appl Pharmacol. 242(1):29-37, 2010.

Gittard SD, Ovsianikov A, Monteiro-Riviere NA, Lusk J, Morel P, Minghetti P,Lenardi C,Chichkov BN, Narayan RJ. Fabrication of microneedles using a two-photon polymerization and micromolding process. Journal of Diabetes Science and Technology  3:304-311, 2009.

Zhang LW,  Yang J, Barron AR, Monteiro-Riviere NA.  Endocytic mechanisms and toxicity of a functionalized fullerene in human cells. Toxicology Letters 191:149-157, 2009.

Adiga S, Jin C, Curtiss LA, Monteiro-Riviere NA, Narayan RJ. Nanoporous membranes for medical and biological applications. WIRES Nanomedicine and Nanobiotechnology 1:568-581, 2009.

Riviere JE, Monteiro-Riviere NA. Cutaneous Toxicology. In General and Applied Toxicology, (Ballentyne B, Marrs T, eds).  3rd Ed. Wiley: West Sussex, UK, Chapter 44, 1003-1015, 2009.

Monteiro-Riviere NA, Riviere JE Interaction of nanomaterials with skin: Aspects of absorption and biodistribution. Nanotoxicology 3(3):188-193, 2009.

Thomas K, Monteiro-Riviere N, Warheit D. Evaluating the risks associated with nanomaterials. In The Oxford Handbook of Nanoscience and Technology, Frontiers and Advances (Narlikar AV, Du YY, eds).  Vol, III, Oxford University Press, Oxford, UK. Chapter 25, 888-906, 2009.

Boehm R, Narayan RJ, Aggarwal R, Monteiro-Riviere NA, Lacour S. Stretchable diamond-like carbon microstructures for biomedical applications. Journal of the Minerals, Metals and Materials Society 61:46-51, 2009.

Zhang LW, Monteiro-Riviere NA. Mechanisms of quantum dot nanoparticle cellular uptake. Toxicological Sciences 110:138-155, 2009.

Sumanasinghe RD, Monteiro-Riviere NA, Loboa EG. Expression of proinflammatory cytokines by human mesenchymal stem cells under cyclic tensile strain. Journal of Cellular Physiology 219:77-83, 2009.

Gittard SD, Narayan RJ, Lusk J, Morel P Stockmans F, Ramsey M, Laverde C, Phillips J, Monteiro-Riviere NA, Ovsianikov A, Chichkov BN. Rapid prototyping of scaphoid and lunate bones. Biotechnology Journal 4:129-134, 2009.

Lee HA, Leavens TL, Mason SE, Monteiro-Riviere NA, Riviere JE. Comparison of.quantum dot biodistribution with a blood-flow-limited physiologically based pharmacokinetic model. Nano Letters 9(2):794-799, 2009.

Monteiro-Riviere NA, Inman AO, Zhang LW. Limitations and relative utility of screening assays to asses engineered nanoparticle toxicity in a human cell line. Toxicology and Applied Pharmacology 234:222-235, 2009.

Elder A, Lynch I, Grieger K, Chan-Remillard S, Gatti A,Gnewuch H, Kenawy E, Korenstein R, Kuhlbusch T, Linker F, Matias S, Monteiro-Riviere N, Pinto V, Rudnitsky R, Savolainen K, Shvedova A. Human Health Risks of Engineered Nanomaterials. In Nanomaterials: Risks and Benefits. (Linkov I, Steevens J, eds). Springer, Dordrecht, Netherlands, 1-28, 2008.

Monteiro-Riviere NA, Zhang LW. Assessment of Quantum Dot Penetration into Skin in Different Species Under Different Mechanical Actions. In Nanomaterials: Risks and Benefits. (Linkov I, Steevens J, eds). Springer, Dordrecht, Netherlands, pp. 41-52, 2008.

Narayan RJ, Aggarwal R, Wei W, Jin C, Monteiro-Riviere NA, Crombez R, Shen W.  Mechanical and biological properties of nanoporous carbon membranes. Biomedical Materials 3:034107, 2008.

Monteiro-Riviere NA: Dermatotoxicology. In Molecular and Biochemical Toxicology. (Smart RC, Hodgson E, eds). 4th Ed, Wiley &Sons, NJ, Chapter 35, 851-880, 2008.

O’Neill AT, Monteiro-Riviere NA, Walker GM. Characterization of microfluidic human epidermal keratinocyte culture. Cytotechnology 56:197-207, 2008.

Zhang LW, and Monteiro-Riviere NA: Assessment of quantum dot penetration into intact, tape stripped, abraded and flexed rat skin. Skin Pharmacology and Physiology 21:166-180, 2008.

Inman AO, Monteiro-Riviere NA, Riviere JE: Inhibition of jet fuel aliphatic hydrocarbon induced toxicity in human epidermal keratinocytes. Journal of Applied Toxicology 28:543-553, 2008.

Zhang LW, Yu WW, Colvin VL, Monteiro-Riviere NA. Biological Interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes. Toxicology and Applied Pharmacology 228:200-211, 2008.

Lin JY, Tournas JA, Burch JA, Selim MA, Monteiro-Riviere NA, Zielinski J. Topical isoflavones provide effective photoprotection to skin. Photodermatology, Photoimmunology and Photomedicine 24:61-66, 2008. 

Karakoti AS, Monteiro-Riviere NA, Aggarwal R, Davis JP, Narayan RJ, Self WT, McGinnis J, Seal S. Nanoceria as antioxidant: synthesis and biomedical applications. Journal of Material Sciences 60:33-37, 2008.

Rouse JG, Haslauer CM, Loboa EG, Monteiro-Riviere NA. Cyclic tensile strain increases interactions between human epidermal keratinocytes and quantum dot nanoparticles. Toxicology in Vitro 22:491-497, 2008.

Roberts MS, Gierden A, Riviere JE, Monteiro-Riviere NA. Solvent and Vehicle Effects on the Skin. In Dermal Absorption and Toxicity Assessment. (Roberts MS, Walters KA, eds). 2nd Ed, Informa Healthcare, New York, NY, Chapter 24, 433-447, 2008.

Monteiro-Riviere NA, Baynes RE, Riviere JE. Animal Skin Morphology and Dermal Absorption. In Dermal Absorption and Toxicity Assessment. (Roberts MS, Walters KA, eds). 2nd Ed, Informa Healthcare, New York, NY, Chapter 2, 17-35, 2008.

Monteiro-Riviere NA. Anatomical Factors that Affect Barrier Function. In Dermatotoxicology. (Zhai H, Wilhelm KP, Maibach HI, eds), 7th Ed, CRC Press, New York, NY, Chapter 4, 39-50, 2008.

McCullen SD, Stano KL, Stevens DR, Roberts WA, Monteiro-Riviere NA, Clarke LI, Gorga RE. Development, optimization and characterization of electrospun poly (lactic) nanofibers containing multi-walled carbon nanotubes. Journal of Applied Polymer Science 105:1668-1678, 2007.

Xia XR, Baynes RE, Monteiro-Riviere NA, Riviere JE. A system coefficient approach for quantitative assessment of the solvent effects on membrane absorption from chemical mixtures. SAR QSAR Environmental Research 18(5):579-593, 2007.

Balbus JM, Maynard AD, Colvin VL, Castranova V, Daston GP, Denison RA, Dreher KL, Goering PL, Goldberg AM, Kulinowski KM, Monteiro-Riviere NA, Oberdorster G, Omenn GS, Pinkerton KE, Ramos KS, Rest KM, Sass JB, Silbergeld EK, Wong BA. Meeting Report: Hazard assessment for nanoparticles-report from an interdisciplinary workshop. Environmental Health Perspectives 115:1654-1659, 2007.

Lee HA, Imran M, Monteiro-Riviere NA, Colvin VL, Yu WW, Riviere JE. Biodistribution of quantum dot nanoparticles in perfused skin: evidence of coating-dependency and periodicity in arterial extraction. Nano Letters 7:2865-2870, 2007.

Monteiro-Riviere NA, Orsiere T. Toxicological Impacts of Nanomaterials. In Environmental Nanotechnology: Applications and Impacts of Nanomaterials. (Wiesner MR, Bottero JY, eds). McGraw-Hill New York, NY, Chapter 11,395-444, 2007.

Xia XR, Baynes RE, Monteiro-Riviere NA, Riviere JE. An experimentally based approach for predicting skin permeability of chemicals and drugs using a membrane-coated fiber array. Toxicology and Applied Pharmacology 221:320-328, 2007.

Ryman-Rasmussen JP, Riviere JE, Monteiro-Riviere NA. Variables influencing interactions of untargeted quantum dot nanoparticles with skin cells and identification of biochemical modulators. Nano Letters 7(5):1344-1348, 2007.

Witzmann FA, Monteiro-Riviere NA. Effect of Carbon Nanotube Exposure on Keratinocyte Protein Expression. In Nanotoxicology: Characterization, Dosing, and Health Effects. (Monteiro-Riviere NA, Tran CL, eds). Informa Healthcare, New York, NY, Chapter 13, 197-224, 2007.

Monteiro-Riviere NA, Inman AO, Ryman-Rasmussen JP. Dermal Effects of Nanomaterials. In Nanotoxicology: Characterization, Dosing, and Health Effects. (Monteiro-Riviere NA, Tran CL, eds). Informa Healthcare, New York, NY, Chapter 19, 317-337, 2007.

Zhang L, Zeng L, Barron AR, Monteiro-Riviere NA. Biological interaction of functionalized single-walled carbon nanotubes in human keratinocytes. International Journal of Toxicology 26:103-113, 2007.

Ovsianikov A, Chichkov B, Mente P, Monteiro-Riviere NA, Doraiswamy A, Narayan RJ. Two photon polymerization of polymer-ceramic hybrid materials for transdermal drug delivery. International Journal of Applied Ceramic Technology 4:22-29, 2007.

Walker GM,  Monteiro-Riviere NA, Rouse JG, O'Neil AT. A linear dilution microfluidic device for nanomaterial cytotoxicity assays. Lab Chip 7:226-232, 2007.

Wei W, Sethurman A, Jin C, Monteiro-Riviere NA, Narayan RJ. Biological properties of carbon nanotubes. Journal of Nanoscience and Nanotechnology 7:1284-1297, 2007.

Rouse JG, Yang J, Ryman-Rasmussen JP, Barron AR, Monteiro-Riviere NA. Effects of mechanical flexion on the penetration of fullerene amino acid-derivatized peptide nanoparticles through skin. Nano Letters 7:155-160, 2007.

Leduc PR, Wong MS, Ferreira PM, Groff RE, Haslinger K, Koonce MP, Lee WY, Love JC, McCammon JA, Monteiro-Riviere NA, Rotello VM, Rubloff GW, Westervelt R, Yoda M. Towards an in vivo biologically inspired nanofactory. Nature Nanotechnology 2:3-7, 2007.

Ryman-Rasmussen JP, Riviere JE, Monteiro-Riviere NA. Surface coatings determine cytotoxicity and irritation potential of quantum dot nanoparticles in epidermal keratinocytes. Journal of Investigative Dermatology 127:143-153, 2007.

Xia XR, Monteiro-Riviere NA, Riviere JE. Trace analysis of fullerenes in biological samples by simplified liquid-liquid extraction and high-performance liquid chromatography. Journal of Chromatography A 1129:216-222, 2006.

Witzmann FA, Monteiro-Riviere NA. Multi-walled carbon nanotube exposure alters protein expression in human keratinocytes. Nanomedicine: Nanotechnology, Biology, and Medicine 2:158-168, 2006.

Chou CC, Yang JH, Chen SD, Monteiro-Riviere NA, Li HN, Chen JJW. Expression profiling of human epidermal keratinocyte response following 1-minute JP-8 exposure. Journal of Cutaneous and Ocular Toxicology 25:141-153, 2006.

Wei C, Lyubchencho YL, Ghandehari H, Hanes J, Stebe KL, Mao HQ, Haynie DT, Tomalia DA, Foldvari M, Monteiro-Riviere N, Simeonova P, Nie S, Mori H, Gilbert SP, Needham D. New technology and clinical applications of nanomedicine: highlights of the second annual meeting of the American Academy of Nanomedicine (Part I). Nanomedicine: Nanotechnology, Biology and Medicine 2:253-263, 2006.

Rouse JG, Yang J, Barron AR, Monteiro-Riviere NA. Fullerene-based amino acid nanoparticle interactions with human epidermal keratinocytes. Toxicology in Vitro 20:1313-1320, 2006.

Monteiro-Riviere NA, Inman AO, Barlow, BM, Baynes, RE. Dermatotoxicity of cutting fluid mixtures: in vitro and in vivo studies. Cutaneous and Ocular Toxicology 25:235-247, 2006.

Ryman-Rasmussen JP, Riviere JE, Monteiro-Riviere NA. Penetration of intact skin by quantum dots with diverse physicochemical properties. Toxicological Sciences 91:159-165, 2006.

Yang J-H, Lee C-H, Monteiro-Riviere NA, Riviere JE, Tsang C-L, Chou C-C. Toxicity of jet fuel aliphatic and aromatic hydrocarbon mixtures on human epidermal keratinocytes: evaluation based on in vitro cytotoxicity and interleukin-8 release. Archives of Toxicology 80:508-523, 2006.

Monteiro-Riviere NA, Inman A, Hedgepeth V, Mosteller B, Piedrahita J. Dermatological effects of chronic exposure to 7,12-dimethylbenz[a]anthracene (DMBA) or N-methyl-n-nitrosoguanidine (MNNG) in swine. Cutaneous and Ocular Toxicology 25:103-119, 2006.

Monteiro-Riviere NA. The Integument. In Dellman’s Textbook of Veterinary Histology. (Eurell JA, Frappier BL, eds). 6th Ed. Blackwell Publishing, Ames, Iowa. Chapter 16, 320-349, 2006.

Monteiro-Riviere NA, Ryman-Rasmussen JP. Toxicology of Nanomaterials. In Biological Concepts and Techniques in Toxicology, (Riviere JE, ed). Taylor and Francis, Chapter 12, 217-233, 2006.

Tournas JA, Lin FH, Burch JA, Selim MA, Monteiro-Riviere NA, Zielinski JE, Pinnell SR. Ubiquinone, idebenone and kinetin provide ineffective photoprotection to skin when compared to a topical antioxidant combination of vitamins C and E with ferulic acid. Journal of Investigative Dermatology 126:1185-1187, 2006.

Monteiro-Riviere NA, Inman AO. Challenges for assessing carbon nanomaterial toxicity to the skin. Carbon 44:1070-1078, 2006.

van der Merwe D, Brooks JD, Gehring R, Baynes RE, Monteiro-Riviere NA, Riviere JE. A physiological-based pharmacokinetic model of organophosphate dermal absorption. Toxicological Sciences 89:188-204, 2006.

Monteiro-Riviere NA. Structure and function of the skin. In Dermal Absorption Models in Toxicology and Pharmacology, (Riviere JE, ed). CRC Press, Taylor and Francis Group, New York, NY. Chapter 1, 1-19, 2006.

Monteiro-Riviere NA, Riviere JE. The pig as a model for human skin research. In Swine in Biomedical Research: Update on Animal Models. (Swindle M, Bouchard GF, eds). Sinclair Research Center, 17-22, 2005.

Ferreira P, Groff R, Haslinger K, Koonce M, Le Duc P, Lee W, Love C, Mc Gammon A, Monteiro-Riviere NA, Rotello V, Rubloff G, Westervelt R, Wong M, Yoda M. An in vivo nanofactory: the medicine of the future. National Academies on Designing Nanostructures at the Interface between Biomedical and Physical Systems. The National Academies Press, Washington, DC, 53-60, 2005.

Monteiro-Riviere NA, Inman AO, Wang YY, Nemanich RJ. Surfactant effects on carbon nanotube interactions with human epidermal keratinocytes. Nanomedicine: Nanotechnology, Biology and Medicine 1:293-299, 2005.

Holsapple, MP, Farland WH, Landry TD, Monteiro-Riviere NA, Carter JM, Walker NJ, Thomas KV. Research Strategies for Safety Evaluation of Nanomaterials, Part II: Toxicological and safety evaluation of nanomaterials, current challenges and data needs. Toxicological Sciences 88:12-17, 2005.

Witzmann FA, Monteiro-Riviere NA, Inman AO, Kimpel MA, Pedrick NM, Ringham HN, Riviere JE. Effect of JP-8 jet fuel exposure on protein expression in human keratinocyte cells in culture. Toxicology Letters 160:8-21, 2005.

Oberdorster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman, K, Carter J, Karn B, Kreyling W, Lai D, Olin S, Monteiro-Riviere NA, Warheit D, Yang H, and A Report from the ILSI Research Foundation/Risk Science Institute Nanomaterial Toxicity Screening Working Group. Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Particle and Fibre Toxicology 2:(8):1-35, 2005.

Lin FH, Lin JY, Gupta RD, Tournas JA, Burch JA, Selim MA, Monteiro-Riviere NA, Grichnik JM, Zielinski J, Pinnell SR. Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. Journal of Investigative Dermatology 125:826-832, 2005.

Monteiro-Riviere NA, Nemanich RJ, Inman AO, Wang YY, Riviere JE. Multi-walled carbon nanotube interactions with human epidermal keratinocytes. Toxicology Letters 155:377-384, 2005.

Xia, XR, Baynes RE, Monteiro-Riviere NA, Riviere JE. Determination of the partition coefficients in a lipophilic membrane/water system by using a membrane-coated fiber technique. European Journal of Pharmaceutical Sciences 24:15-23, 2005.

Muhammad F, Monteiro-Riviere NA, Riviere JE. Comparative in vivo of topical JP-8 jet fuel and its individual hydrocarbon components: identification of tridecane and tetradecane as key constituents responsible for dermal irritation. Toxicologic Pathology 33:258-266, 2005.

Muhammad F, Monteiro-Riviere NA, Baynes RE, Riviere JE. Effect of in vivo jet fuel exposure on subsequent in vitro dermal absorption of individual aromatic and aliphatic hydrocarbon fuel constituents. Journal of Toxicology and Environmental Health 68:719-737, 2005.

Xia XR, Baynes, RE, Monteiro-Riviere NA, Riviere JE. Membrane uptake kinetics of jet fuel aromatic hydrocarbons from aqueous solutions studied by a membrane-coated fiber technique. Toxicology Mechanisms and Methods 15:307-316, 2005.


Membership of Professional Societies

Dr. Nancy Monteiro is a member of the following societies: