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CCTRP Faculty Members:

Staff Members:

  • Jim D. Brooks, MS, Laboratory Supervisor
  • Patty Routh, Research Specialist
  • Jim L. Yeatts, MS, Laboratory Research Specialist/Analytical Chemist

CCTRP Graduate Students/Trainess

  • Daniella Karadzovska, BS, Ph.D candidate
  • Alexcia Linthicum, BS, MS, Ph.D. Student
  • Lindsey Waltman, BS, MS, DVM/Ph.D. candidate

Jim E. Riviere, D.V.M., Ph.D., DSc (hon)

Jim Riviere

Center for Chemical Toxicology Research and Pharmacokinetics College of Veterinary Medicine BOX 8410 4700 Hillsborough St. Raleigh, NC 27606
Phone: (919) 513-6305
Fax: (919) 513-6358
Email: Jim_Riviere@ncsu.edu

Biographical Sketch

Jim E. Riviere is the Burroughs Wellcome Fund Distinguished Professor of Pharmacology; and Director, Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine; North Carolina State University (NCSU) in Raleigh NC. Dr. Riviere received his BS (summa cum laude) and MS degrees from Boston College, his DVM and PhD in pharmacology as well as a DSc (hon) from Purdue University. He is an elected member of the Institute of Medicine of the National Academies, serves on its Food and Nutrition Board, and is a fellow of the Academy of Toxicological Sciences. He is a member of Phi Beta Kappa, Phi Zeta and Sigma Xi, and has served on the Science Board of the Food and Drug Administration. His honors include the 1999 O. Max Gardner Award from the Consolidated University of North Carolina, the 1991 Ebert Prize from the American Pharmaceutical Association, the Harvey W. Wiley Medal and FDA Commissioner’s Special Citation, and the Lifetime Achievement Award from the European Association of Veterinary Pharmacology and Toxicology. He is the Editor of the Journal of Veterinary Pharmacology and Therapeutics, co-founder and co-director of the USDA Food Animal Residue Avoidance Databank (FARAD) program, and was formerly the Director of the Biomathematics Program in the College of Physical and Mathematical Sciences at NCSU. He has served as an officer in various Specialty Sections of the Society of Toxicology, and has served on the Editorial Boards of various toxicology, pharmacology and veterinary journals. He has published over 430 full-length research papers and chapters, holds 5 U.S. Patents, has authored/edited 10 books in pharmacokinetics, toxicology and food safety, and received over 16 million dollars as principal investigator on eatramural research grants. His current research interests relate to the development of animal models; applying biomathematics to problems in toxicology, including the risk assessment of chemical mixtures, pharmacokinetics, nanomaterials, absorption of drugs and chemicals across skin; and the food safety and pharmacokinetics of tissue residues in food producing animals.

Selected Publications

Riviere JE, Inman AO, Monteiro-Riviere NA. Absorption, Penetration and Cutaneous Toxicity of Jet Fuels and Hydrocarbons Components. In Jet Fuel Toxicology  (Witten ML, Zeiger E, Ritchie GD, eds). CRC Press, Boca Raton, Fl, Chapter 7, 119-134, 2010.  

Ghafourian T, Samaras EG, Brooks JD, Riviere JE. Modelling the effects of mixture components on permeation through skin. International Journal of Pharmaceutics. 398:28-32, 2010.

Xia XR, Monteiro-Riviere NA, Riviere JE. An index for characterization of nanomaterials in biological systems.  Nature Nanotechnology. 5(9):671-675, 2010.

Baynes RE, Riviere JE. Dermal Chemical Mixtures. Mixtures Toxicity. In Principles and Practice of Mixtures Toxicity. (Mumtaz MM, ed).Wiley-VCH Weinheim, Chapter 14, 349-376, 2010.

Riviere JE, Monteiro-Riviere NA.  Toxicokinetics: Dermal Exposure and Absorption of Chemicals and Nanomaterials. In Comprehensive Toxicology, 2nd Ed. (McQueen C, ed). Elsevier, NY, Vol. 1. Chapter 1.05:111-122, 2010.

Xia XR, Monteiro-Riviere NA, Riviere JE.  Intrinsic biological property of colloidal fullerene nanoparticles (nC60): lack of lethality after high dose exposure to human epidermal and bacterial cells. Toxicology Letters 197(2):128-134, 2010.

Leavens TL, Xia XR, Lee HA, Monteiro-Riviere NA, Brooks JD, Riviere JE. Evaluation of perfused porcine skin as a model system to quantitate tissue distribution of fullerene nanoparticles. Toxicology Letters 197(1):1-6, 2010.

Riviere JE. New Technologies for Application to Veterinary Therapeutics. In Comparative and Veterinary Pharmacology. Handbook of Experimental Pharmacology. (Cunningham F, Elliott J, Lees P, eds). Springer, NY, 191-210, 2010.

Riviere JE. Dermal Absorption Modeling. In  Human Exposure to Pollutants via Dermal Absorption and Inhalation. Environmental Pollution Vol. 17 (Lazaridis M, Colbeck I, eds). Springer, UK, Chapter 7, 237-249, 2010.

Riviere JE, Brooks JD, Yeatts JL, Koivisto EL. Surfactant effects on skin absorption of model organic chemicals: implications for dermal risk assessment studies. Journal of Toxicology and Environmental Health Part A 73:725-737, 2010.

Riviere JE. Basic Principles Involved in Quantifying the Dermal Absorption of Topically Applied Chemicals. In Toxicology of the Skin-Target Organ Series. (Monteiro-Riviere NA, ed). Informa Healthcare, New York, NY, Vol. 29, Chapter 5, 43-54, 2010.

Xia XR, Monteiro-Riviere NA, Riviere JE. Skin penetration and kinetics of pristine fullerenes (C60) topically exposed in industrial organic solvents. Toxicology and Applied Pharmacology. 242(1):29-37, 2010.  PMID: 19796651

Mason SE, Baynes RE, Almond GW, Riviere JE, Scheidt AB. Pharmacology of tetracycline water medication in swine. Journal of Animal Science 87:3179-3186, 2009.

Riviere JE, Monteiro-Riviere NA. Cutaneous Toxicology. In General and Applied Toxicology, (Ballentyne B, Marrs T, eds).  3rd Ed. Wiley: West Sussex, UK, Chapter 44, 1003-1015, 2009.

Vijay V, White EM, Kaminski Jr. MD, Riviere JE, Baynes RE. Dermal permeation of biocides and aromatic chemicals in three generic formulations of metalworking fluids.  Journal of Toxicology and Environmental Health 72:832-841, 2009.

Riviere JE, Brooks JD. Determination of the effective dermal penetration barrier pH of porcine skin. Journal of Veterinary Pharmacology and  Therapeutics. 32:407-410, 2009.

Lee HA, Leavens TL, Mason SE, Monteiro-Riviere NA, Riviere JE. Comparison of. quantum dot biodistribution with a blood-flow-limited physiologically based pharmacokinetic model. Nano Letters 9(2):794-799, 2009.

Smith GW, Davis JL, Baynes RE, Yeatts JL, Barlow BM, Riviere JE. Elimination kinetics of tilmicosin following intramammary administration in lactating dairy cattle. Journal of the American Veterinary Association 234:245-248, 2009.

Riviere JE. Pharmacokinetics of nanomaterials: an overview of carbon nanotubes, fullerenes and quantum dots. Wiley Interdisciplinary. Reviews Nanomedicine and Nanobiotechnology. 1(1):26-34, 2009.

Buur JL, Baynes RE, Riviere JE. Estimating meat withdrawal times in pigs exposed to melamine contaminated feed using a physiologically based pharmacokinetic model. Regulatory Toxicology and Pharmacology 51:324-331, 2008.

Inman AO, Monteiro-Riviere NA, Riviere JE. Inhibition of jet fuel aliphatic hydrocarbon  induced toxicity in human epidermal keratinocytes. Journal of Applied Toxicology 28:543-553, 2008.

Baynes RE, Xia XR, Vijay V, Riviere JE. A solvatochromatic approach to quantifying formulation effects on dermal permeability. SAR QSAR Environ Res. 19(7-8):615-630, 2008.

Yeatts JL, Baynes RE, Xia XR, Riviere JR. Application of linear salvation energy relationships to a custom-made polyaniline solid-phase microextraction fiber and three commercial fibers. J Chromatography A. 1188:108-117, 2008.

Baynes RE, Xia XR, Imran M, Riviere JE. Quantification of chemical mixture interactions modulating dermal absorption using a multiple membrane fiber array. Chemical Research in Toxicology 21:591-599, 2008.

Mason SE, Baynes RE, Buur JL, Riviere JE, Almond GW. Sulfamethazine water medication pharmacokinetics and contamination in a commercial pig production unit. Journal of  Food Protection 71:584-589, 2008.

Smith GW, Davis JL, Tell LA, Webb AI, Riviere JE. Extralabel use of nonsteroidal ant-inflammatory drugs in cattle. Journal of the American Veterinary Medical Association 232:697-701, 2008.

Baynes RB, Smith G, Mason SE, Barrett E, Barlow BM, Riviere JE. Pharmacokinetics of melamine in pigs following intravenous administration. Food and Chemical Toxicology 46:1196-1200, 2008.

Roberts MS, Gierden A, Riviere JE, Monteiro-Riviere NA. Solvent and Vehicle Effects on the Skin. In Dermal Absorption and Toxicity Assessment. (Roberts MS, Walters KA, eds). 2nd Ed, Informa Healthcare, New York, NY, Chapter 24, 433-447, 2008.

Monteiro-Riviere NA, Baynes RE, Riviere JE. Animal Skin Morphology and Dermal Absorption. In Dermal Absorption and Toxicity Assessment. (Roberts MS, Walters KA, eds). 2nd Ed, Informa Healthcare, New York, NY, Chapter 2, 17-35, 2008.

Riviere JE: Isolated Perfused Porcine Skin Flap. In Dermatotoxicology. (Zhai H, Wilhelm KP, Maibach HI, eds). 7th Ed, CRC Press, New York, NY, Chapter 40, 347-358, 2008.

Riviere JE: Percutaneous Absorption of Complex Chemical Mixtures. In Dermatotoxicology. (Zhai H, Wilhelm KP, Maibach HI, eds). 7th Ed, CRC Press, New York, NY, Chapter 6, 63-70, 2008.

Riviere JE, Xia XR, Baynes RE. Membrane coated fiber (MCF) array approach for predicting skin permeability of chemical mixtures from different vehicles. Toxicological Science 99:153-161, 2007.

Xia XR, Baynes RE, Monteiro-Riviere NA, Riviere JE: A system coefficient approach for quantitative assessment of the solvent effects on membrane absorption from chemical mixtures. SAR QSAR Environmental Research 18(5):579-593, 2007.

Needham ML, Webb AI, Baynes RE, Riviere JE, Craigmill AL, Tell LA. Current update on drugs for game bird species. Journal of the American Veterinary Medical Association 231:1506-1508, 2007.

Baynes RE, Xia XR, Barlow BM, Riviere JE. Partitioning behavior of aromatic components in jet fuel into diverse membrane-coated fibers. Journal of Toxicology and Environmental Health 70:1879-1887, 2007.

Vijay V, Yeatts JL, Riviere JE, Baynes RE. Predicting dermal permeability of biocides in commercial cutting fluids using a LSER approach. Toxicology Letters 175:34-43, 2007.

Riviere JE. The future of veterinary therapeutics: a glimpse towards 2030. The Veterinary Journal 174:462-471, 2007.

Lee HA, Imran M, Monteiro-Riviere NA, Colvin VL, Yu WW, Riviere JE. Biodistribution of quantum dot nanoparticles in perfused skin: evidence of coating-dependency and periodicity in arterial extraction. Nano Letters 7:2865-2870, 2007.

Riviere JE, Tran CL. Pharmacokinetics of Nanomaterials. In Nanotoxicology: Characterization, Dosing, and Health Effects. (Monteiro-Riviere NA, Tran CL, eds). Informa Healthcare, New York, NY, Chapter 9, 127-152, 2007.

Calabrese EJ, Riviere JE, Mattson MP. Biological stress response terminology: integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicology and Applied Pharmacology 222:122-128, 2007.

Riviere, JE. Dermatotoxicology: computational risk assessment. In Computational Toxicology Risk Assessment for Pharmaceutical and Environmental Chemicals (Ekins S, ed). Wiley, 677-692, 2007.

Xia XR, Baynes RE, Monteiro-Riviere NA, Riviere JE. An experimentally based approach for predicting skin permeability of chemicals and drugs using a membrane-coated fiber array. Toxicology and Applied Pharmacology 221:320-328, 2007.

Ryman-Rasmussen JP, Riviere JE, Monteiro-Riviere NA. Variables influencing interactions of untargeted quantum dot nanoparticles with skin cells and identification of biochemical modulators. Nano Letters 7(5):1344-1348, 2007.

Muhammad F, Riviere JE. Dermal Toxicity. In Veterinary Toxicology, (Gupta RC, ed). 1st Ed., Elsevier, New York, NY, Chapter 16, 263-276, 2007.

van der Merwe D, Buur JL, Riviere JE. Physiologically based pharmacokinetic modeling. In Veterinary Toxicology, (Gupta RC, ed). 1st Ed., Elsevier, New York, NY, Chapter 3, 42-50, 2007.

KuKanich B, Huff D, Riviere JE, Papich MG. Naïve averaged, naïve pooled, and population pharmacokinetics of orally administered marbofloxacin in juvenile harbor seals. Journal of the American Veterinary Medical Association 230: 390-395, 2007.

Riviere JE, Brooks JD. Prediction of dermal absorption from complex chemical mixtures: incorporation of vehicle effects and interactions into a QSPR framework. SAR and QSAR in Environment Research 18:31-44, 2007.

Ryman-Rasmussen JP, Riviere JE, Monteiro-Riviere NA. Surface coatings determine cytotoxicity and irritation potential of quantum dot nanoparticles in epidermal keratinocytes. Journal of Investigative Dermatology 127:143-153, 2007.

Kong XQ, Shea D, Baynes RE, Riviere JE, Xia XR. Regression method of the hydrophobicity ruler approach for determining octanol/water partition coefficients of very hydrophobic compounds. Chemosphere 66(6):1086-93 2006.

Xia XR, Monteiro-Riviere NA, Riviere JE. Trace analysis of fullerenes in biological samples by simplified liquid-liquid extraction and high-performance liquid chromatography. Journal of Chromatography A 1129:216-222, 2006.

Payne MA, Craigmill A, Riviere JE,Webb AI. Extralabel use of penicillin in food animals. Journal of the American Veterinary Medical Association 229:1401-1403, 2006.

Buur JL, Baynes RE, Smith G, Riviere JE. Pharmacokinetics of flunixin meglumine in swine after intravenous dosing. Journal of Veterinary Pharmacology and Therapeutics 29:437-440, 2006.

van der Merwe D, Riviere JE. Cluster analysis of the dermal permeability and stratum corneum/solvent partitioning of ten chemicals in twenty-four chemical mixtures in porcine skin. Skin Pharmacology and Physiology 19:198-206, 2006.

Buur J, Baynes R, Smith G, Riviere JE. Use of probabilistic modeling within a physiologically based pharmacokinetic model to predict sulfamethazine residue withdrawal times in edible tissues in swine. Antimicrobial Agents and Chemotherapy 50:2344-2351, 2006.

Yang J-H, Lee C-H, Monteiro-Riviere NA, Riviere JE, Tsang C-L, Chou C-C. Toxicity of jet fuel aliphatic and aromatic hydrocarbon mixtures on human epidermal keratinocytes: evaluation based on in vitro cytotoxicity and interleukin-8 release. Archives of Toxicology 80:508-523, 2006.

Ryman-Rasmussen JP, Riviere JE, Monteiro-Riviere NA. Penetration of intact skin by quantum dots with diverse physicochemical properties. Toxicological Sciences 91:159-165, 2006.

Gehring R, Baynes RE, Riviere JE. Application of risk assessment and management principles to the extralabel use of drugs in food-producing animals. Journal of Veterinary Pharmacology and Therapeutics 29:5-14, 2006.

Riviere JE. Dermal Absorption/Toxicity of Organophosphates and Carbamates. In Toxicology of Organophosphate and Carbamate Compounds, (Gupta RC, ed). Elsevier Academic Press, Chapter 30, 411-422, 2006.

Riviere JE. Chemical Mixtures. In Dermal Absorption Models in Toxicology and Pharmacology. (Riviere JE, ed). CRC Press, Taylor and Francis Group, New York, NY. Chapter 14, 283-304, 2006.

Xia XR, Baynes RE, Riviere JE. A Novel System Coefficient Approach for Systematic Assessment of Dermal Absorption from Chemical Mixtures. In Dermal Absorption Models in Toxicology and Pharmacology. (Riviere JE, ed). CRC Press, Taylor and Francis Group, New York, NY. Chapter 5, p.71-88, 2006.

Muhammad F, Riviere JE. In Vivo Models. In Dermal Absorption Models in Toxicology and Pharmacology. (Riviere JE, ed). CRC Press, Taylor and Francis Group, New York, NY. Chapter 4, 49-70, 2006.

Riviere JE. Perfused Skin Models. In Dermal Absorption Models in Toxicology and Pharmacology. (Riviere JE, ed). CRC Press, Taylor and Francis Group, New York, NY. Chapter 3, 29-48, 2006.

van der Merwe D, Brooks JD, Gehring R, Baynes RE, Monteiro-Riviere NA, Riviere JE. A physiological-based pharmacokinetic model of organophosphate dermal absorption. Toxicological Sciences 89:188-204, 2006.

Baynes RE, Brooks JD, Barlow BM, Riviere JE. NDELA and nickel modulation of triazine disposition in skin. Toxicology and Industrial Health, 21:197-205, 2005.

Monteiro-Riviere NA, Riviere JE. The Pig as a Model for Human Skin Research. In Swine in Biomedical Research: Update on Animal Models. (Swindle M, Bouchard GF, eds). Sinclair Research Center, 17-22, 2005.

Baynes RE, Yeatts JL, Brooks JD, Riviere JE. Pre-treatment effects of trichloroethylene on the dermal absorption of the biocide, triazine. Toxicology Letters 159:252-260, 2005.

KuKanich B, Gehring R, Webb AI, Craigmill AL, Riviere JE. Effect of formulation and route of administration on tissue residues and withdrawal times. Journal of the American Veterinary Medical Association 227:1574-1577, 2005.

Buur JL, Baynes RE, Craigmill AL, Riviere JE. Development of a physiologic-based pharmacokinetic model for estimating sulfamethazine concentrations in swine and application to prediction of violative residues in edible tissues. American Journal of Veterinary Research 66:1686-1693, 2005.

Witzmann FA, Monteiro-Riviere NA, Inman AO, Kimpel MA, Pedrick NM, Ringham HN, Riviere JE. Effect of JP-8 jet fuel exposure on protein expression in human keratinocyte cells in culture. Toxicology Letters 160:8-21, 2005.

Riviere JE, Brooks JD. Predicting skin permeability from complex chemical mixtures. Toxicology and Applied Pharmacology 208:99-110, 2005.

Xia XR, Baynes, RE, Monteiro-Riviere NA, Riviere JE. Membrane uptake kinetics of jet fuel aromatic hydrocarbons from aqueous solutions studied by a membrane-coated fiber technique. Toxicology Mechanisms and Methods 15:307-316, 2005.

Gehring R, Haskell SR, Payne MA, Craigmill AL, Webb, AI, Riviere JE. Amino-glycoside residues in food of animal origin. Journal of the Veterinary American Medical Association 227:63-66, 2005.

Smith GW, Gehring R, Craigmill AL, Webb AI, Riviere JE. Extralabel intramammary use of drugs in dairy cattle. Journal of the Veterinary American Medical Association 226:1994-1996, 2005.

Muhammad F, Monteiro-Riviere NA, Baynes RE, Riviere JE. Effect of in vivo jet fuel exposure on subsequent in vitro dermal absorption of individual aromatic and aliphatic hydrocarbon fuel constituents. Journal of Toxicology and Environmental Health 68:719-737, 2005.

Haskell SR, Payne M, Webb A, Riviere JE, Craigmill AL. Antidotes in food animal practice. Journal of the American Veterinary Medical Association 226:884-887, 2005.

Muhammad, F, Monteiro-Riviere NA, Riviere JE. Comparative in vivo toxicity of topical JP-8 jet fuel and its individual hydrocarbon components: identification of tridecane and tetradecane as key constituents responsible for dermal irritation. Toxicologic Pathology 33:258-266, 2005.

Monteiro-Riviere NA, Nemanich RJ, Inman AO, Wang YY, Riviere JE. Multi-walled carbon nanotube interactions with human epidermal keratinocytes. Toxicology Letters 155:377-384, 2005.

Gehring R, van der Merwe D, Pierce A, Baynes R, Craigmill A, Riviere JE. Multivariate meta-analysis of pharmacokinetic studies of ampicillin trihydrate in cattle. American Journal of Veterinary Research 66:108-112, 2005.

Xia, XR, Baynes RE, Monteiro-Riviere NA, Riviere JE. Determination of the partition coefficients in a lipophilic membrane/water system by using a membrane-coated fiber technique. European Journal of Pharmaceutical Sciences 24:15-23, 2005.

Van der Merwe D, Riviere JE. Effect of vehicles and sodium lauryl sulphate on xenobiotic permeability and stratum corneum partitioning in porcine skin. Toxicology 206:325-335, 2005.

Van der Merwe D, Riviere JE. Comparative studies on the effects of water, ethanol and water/ethanol mixtures on chemical partitioning into porcine stratum corneum and silastic membrane. Toxicology in Vitro 19:69-77, 2005.