Faculty

Brian Gilger, DVM, MS, Dipl. ACVO
Professor, Ophthalmology

Doctor of Veterinary Medicine, Ohio State University, 1987
Masters of Science, Ophthalmology, Auburn University, 1992

Phone: 919.513.6239
FAX: 919.513.6711
Email: brian_gilger@ncsu.edu

Clinical Specialty

Ophthalmology, including equine ocular disorders, uveitis, immune-mediated ocular disease, and intraocular surgery such as cataract surgery.

Professional Experience & Qualifications

Diplomate, American College of Veterinary Ophthalmologists, 1993
Professor of Ophthalmology, NC State University, 2003-present
Associate Professor, Ophthalmology, NC State University, 1995-2003
Assistant Professor, Ophthalmology, Ohio State University, 1992-1995
Residency in Ophthalmology, Auburn University, 1989-1992
Graduate Student in Ophthalmology, Auburn University, 1989-1992
Internship, The Animal Medical Center, New York, New York, 1987-1988.

Ocular Drug Development and Toxicology Experience

Research Interests and Expertise

Ocular immunology, inflammation, toxicology, pharmacology, sustained ocular drug delivery.

In the Comparative Ophthalmology Research Laboratory, we study the pathogenesis of ocular immunologic and inflammatory disorders and have developed innovative methods to treat these potentially blinding diseases. We have been especially interested in the study of ocular toxicology and pharmacology of several medications. We are particularly interested in the two main causes of blindness in horses in the southern United States, equine recurrent uveitis and fungal keratitis. We are also interested in studying these naturally-occurring diseases, since they are models of common human diseases. Recently, we have explored methods to deliver therapeutic levels of medications to the eye for extended periods of time using micro-implant technology.

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Recent and Selected Peer-Reviewed Publications (out of 76)

Douglass L, Davis JL, Salmon JH, Yi NY, Gilger BC.  Ocular toxicity and pharmacokinetics of intravitreal and subconjuctival injection of rapamycin (sirolimus) in horses. Vet Pharm Therapeutic (Submitted) 2008 (*Gilger corresponding author)

Sommer JR, Estrada JL, Collins EB, Alexander CA, Howes K, Chen H, Chen W, Mir B, Gilger BC, Piedrahita J, Zhang K, Petters RM. Production of ELOVL4 transgenic pigs: A large animal model for Stargardt-like macular degeneration. (In preparation) 2008

McMullen RM, Gilger BC.  Use of infrared photography in diseases of the anterior segment. Vet Ophthalmol (In press) March 2008. (*Gilger corresponding author)

McMullen RM, Clode AB, Pandiri AR, Malarkey D, Michau TM, Gilger BC.  Epibulbar melanoma in a foal. Vet Ophthalmol (In press) February 2008. (*Gilger corresponding author)

Gilger BC, Salmon JH, Yi NY, Barden CA, Chandler HL, Wendt J, Colitz CMH. Role of Bacteria in Recurrent Uveitis in Eyes of Horses from Southeastern United States.  Am J Vet Res (In press) February 2008

Yi NY, Davis JL. Salmon JH, Gilger BC.  Ocular toxicity and pharmacokinetics of intravitreal injection of triamcinolone in horses. Vet Ophthalmol (In press) January 2008. (*Gilger corresponding author)

Chu PHW, Chan HHL, Ng Y, Brown B, Siu AW, Gilger BC, Wong F. Porcine global-flash multifocal electroretinogram: possible mechanisms for the glaucomatous changes in luminance-modulated adaptation. Invest Ophthalmol Vis Sci 2007 (In Press).

Ng YF, Chan HHL, Chu PHW, Beale BA, Gilger BC, Wong F. Retinal Pharmacologically defined components of the normal porcine multifocal ERG. Doc Ophthalmol. 2007; Aug 25; [Epub ahead of print] PMID: 17721791

Strobel BW, Wilkie DA, Gilger BC.  Retinal detachment in horses: 40 cases. Veterinary Ophthalmology, 2007;10(6):380-385. (*Gilger corresponding author)

Ollivier FJ, Gilger BC, Barrie K, Kallberg ME, Plummer CE, O’Reilly S, Gelatt KN, Brooks DE. Proteinases of the cornea and preocular tear film. Veterinary Ophthalmology 2007;10(4):199–206

Lee S, Kim H, Wang NS, Bungay PM, Gilger BC, Yaun P, Kim J, Csaky KG, Robinson MR. A pharmacokinetic and safety evaluation of an episcleral cyclosporine implant for potential use in high-risk keratoplasty rejection. Invest Ophthalmol Vis Sci 2007;48(5):2023-2029.

Acton AE, Beale AB, Gilger BC, Stoskopf MK. Sustained release cyclosporine therapy for bilateral keratoconjunctivitis sicca in a red wolf (Canis Rufus). Journal of Zoo and Wildlife Medicine 2006:37(4): 562–564.

Beale AB, Salmon JB, Michau TM, Gilger BC. Effect of ophthalmic Nd:YAG laser energy on intraocular lenses after posterior capsulotomy in dogs. Vet Ophthalmol 2006;9:355-340. (*Gilger corresponding author)

McMullen RJ, Gilger BC. Keratometry, biometry, and prediction of intraocular lens power in the equine eye. Vet Ophthalmol 2006;9:357-360. (*Gilger corresponding author)

Gilger BC, Salmon, Wilkie DA, Cruysberg LP, Kim J, Hayat M, Kim H, Kim S, Yaun P, Lee S, Harrington SM, Murray PR, Edelhauser HF, Csasky KG, Robinson MR. A novel bioerodible deep scleral lamellar cyclosporine implant for uveitis. Invest Ophthalmol Vis Sci 2006:47:2596-2605

Clode AB, Davis JL, Salmon J, Michau TM, Gilger BC. Aqueous humor concentration of voriconazole after topical and oral administration in horses. Am J Vet Res 2006;67;296-301. (*Gilger corresponding author)

Gilger BC, Michau TM, Salmon J.  Immune-mediated keratitis in horses: 19 cases (1998–2004).  Vet Ophthalmology 2005; 8(4):233-239.

Gilger BC, Reeves, KA, Salmon J. Ocular parameters related to drug delivery in the canine and equine eye: aqueous and vitreous humor volume and scleral surface area and thickness. Vet Ophthalmol 2005, 8(4):265-270.

Stoppini R, Gilger BC, Malarkey DE, et al. Bilateral nodular lymphocytic conjunctivitis in a horse. Vet Ophthalmology  2005; 8(2): 129-134.

Kim H, Csaky KG, Gilger BC, et al. Preclinical evaluation of a novel episcleral cyclosporine implant for ocular graft-versus-host disease. Invest Ophthalmol Vis Sci 2005; 46(2): 655-662.

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Recent Research Presentations and Abstracts

Gilger BC, Moore CP, Narfstrom K, Liu J, Lawson C,  Cacek T, Anglade E, Velagaleti P. Preclinical Acute Toxicity and Pharmacokinetics of Episcleral LX201 Implants in Rabbits. Invest Ophthalmol Vis Sci. Abstract.  Association of Research in Vision and Ophthalmology Annual Meeting,  Ft Lauderdale, FL , May 2008 (In press).

Salmon JH, Douglass L, Yi NY, Gilger BC.  Ocular toxicity and pharmacokinetics of intravitreal and subconjuctival injection of rapamycin (sirolimus) in horses. Invest Ophthalmol Vis Sci. Abstract.  Association of Research in Vision and Ophthalmology Annual Meeting,  Ft Lauderdale, FL , May 2008 (In press).

Douglas L, Salmon JH, Yi NY, Gilger BC.  Ocular toxicity and pharmacokinetics of intravitreal and subconjuctival injection of rapamycin (sirolimus) in horses. American College of Veterinary Ophthalmologists, Kona, Hawaii, October 2007.

Yi NY, Salmon JH, Gilger BC.  Ocular toxicity and pharmacokinetics of intravitreal injection of triamcinolone in horses. American College of Veterinary Ophthalmologists, Kona, Hawaii, October 2007.

Michau TM, Colitz CMH, Belknap E, Barden CA, Yin C, Salmon JH, Gilger BC. Etiologic testing of deep corneal stromal abscess following penetrating keratoplasty in the horse. American College of Veterinary Ophthalmologists, Kona, Hawaii, October 2007.

Gift BW, English RV, Nadelstein B, Weigt A, Gilger BC. Opacification and refractive status after phacoemulsification cataract removal and replacement intraocular lens implantation in dogs. American College of Veterinary Ophthalmologists, Kona, Hawaii, October 2007.

Michau TM, Salmon JH, English RV, Gilger BC. Transforming growth factor β2 in the aqueous humor of normal dogs and dogs with glaucoma. American College of Veterinary Ophthalmologists, Kona, Hawaii, October 2007.

Gilger BC, Salmon JH, Barden CA, Chandler HL, Wendt J, Colitz CMH. Bacteria in Eyes with Chronic Recurrent Uveitis from Southeastern United States. Annual Meeting of the ESVO – ECVO – ISVO – SOVI
May 30 – June 3, Magazzini del Cotone, Genoa, Italy, May 2007. 

JR Sommer, JL Estrada, EB Collins, H Chen, L Luo, KA Howes, J Piedrahita, B Gilger, K Zhang, and RM Petters. Electroretinography and retinal pathology of two lines of ELOVL4 270stmt transgenic pigs.   Transgene expression levels correlate with the degree of Stargardt-like Macular Degeneration. Invest Ophthalmol Vis Sci. Abstract.  Association of Research in Vision and Ophthalmology Annual Meeting,  Ft Lauderdale, FL , May 2007. 

Ng YF, Chan HHL, Chi PHW, Beale AB, Gilger, BC, Wong F. Retinal origins and non-linear characteristics of  the porcine multifocal ERG. Invest Ophthalmol Vis Sci. Abstract.  Association of Research in Vision and Ophthalmology Annual Meeting,  Ft Lauderdale, FL , May 2007.

Gilger BC, Salmon JH, Barden CA, Chandler HL, Wendt J, Colitz CMH. Bacteria in Eyes with Chronic Recurrent Uveitis from Southeastern United States. Invest Ophthalmol Vis Sci. Abstract.  Association of Research in Vision and Ophthalmology Annual Meeting,  Ft Lauderdale, FL , May 2007.

Salmon JH, Gilger BC. Serum cytokine profiles in horses with recurrent uveitis. Invest Ophthalmol Vis Sci. Abstract.  Association of Research in Vision and Ophthalmology Annual Meeting,  Ft Lauderdale, FL , May 2007. 

Strobel B, Wilkie DA, Gilger BC.  Retinal detachment in horses. American College of Veterinary Ophthalmologists, San Antonio, TX, Nov 2, 2006.

Yuan P,  Gilger BC, Robinson MR. Grimes GJ, Wilson AL, Potti JG. A Novel Bioerodible Suprachoroidal Cyclosporine Implant for Recurrent Uveitis. AAPS  San Antonio TX, October 29-November 2, 2006.

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Recent Books and Book Chapters

Book:

Equine Ophthalmology, Edited by Brian C. Gilger, Published by Elsevier Science, February 2005. 400 pages, 400 color photographs. http://www.us.elsevierhealth.com/product.jsp?isbn=0721605222

Book Chapters (selected from 27):

Gilger BC. Immunology of the ocular surface. In, Williams DA Ed, Veterinary Clinics of North America Small Animal. Elsevier, Phildelphia. Submitted June 2007.

Gilger BC. Enucleation of the Equine Eye. In, Edward Robinson NE, Sprayberry KA, eds. Current Therapy in Equine Medicine 6 th Edition. Submitted May 2007.

Gilger BC. Equine Recurrent Uveitis. In, Edward Robinson NE, Sprayberry KA, eds. Current Therapy in Equine Medicine 6 th Edition. Submitted May 2007.

Gilger BC. Corneal diseases and surgery, In. Gelatt KN ed. Veterinary Ophthalmology 4 th Edition. Philadelphia. Lippincott Williams & Wilkins. 2007.

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Links

Comparative Ophthalmology Research Laboratory, Drs. Alison Clode, Brian Gilger, and Tammy Miller-Michau, Principal Investigators
About Equine Recurrent Uveitis
American College of Veterinary Ophthalmologists
Association in Research in Vision and Ophthalmology

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