| Leukocyte
Biology Laboratory
Welcome
to the Leukocyte Biology Laboratory web site. This site
is designed to provide information about us, our research,
and our collaborative investigations. It also contains
links to many sites of interest.
Lab Members
Sam
Jones, Principal Investigator
Yousuf
Sharief
Research
The
Leukocyte Biology Laboratory is interested in understanding
the molecular mechanisms of phagocyte activation. Specifically,
we are studying the role of cytoskeletal proteins such
as the leukocyte specific actin bundling protein L-plastin
(LPL), in regulating the signaling cascades which lead
to the development of the effector phenotype in neutrophils
and macrophages. We are defining the role of LPL and
the actin cytoskeleton in regulating signal transduction
pathways during integrin activation and the role of
beta 2 integrin (CD11/CD18 complex) activation in adhesion,
respiratory burst and reactive oxygen production, degranulation,
prostaglandin and leukotriene production, migration,
and phagocytosis.
We
are applying this information to clinically important
inflammatory diseases, particularly gastrointestinal
inflammation and arthritis. For example, we are studying
the role of neutrophils in mucosal injury during gastrointestinal
inflammation induced by ischemic injury and the mechanism
of neutrophil and macrophage activation in immune complex
disease such as rheumatoid arthritis. We are also interested
in the strategies used by intracellular bacterial gastrointestinal
pathogens such as Salmonella, to invade macrophages,
modulate their activation, induce apoptosis, and subsequently
evade the host immune response.
For
an updated Medline search click on Sam
Jones Publications
Jones
SL, Blikslager AT. (2002) Role of the enteric nervous
system in the pathophysiology of secretory diarrhea.
J Vet Intern Med 16:222-228.
Campbell NB, Jones SL, Blikslager AT. (2002) The effects
of cyclooxygenase inhibitors on bile-injured and normal
equine colon. Equine Vet J 34:493-498.
Gayle J, Jones SL, Argenzio RA, Blikslager AT. (2002)
Neutrophils increase paracellular permeability of
restituted ischemic injured porcine ileum. Surgery
(In Press).
Chilcoat CD, Rowlingson KA, Jones SL. (2002) The effects
of cAMP modulation upon the adhesion and respiratory
burst activity of immune complex-stimulated equine
neutrophils. Vet Immunol Immunopathol 88:65-77.
Jones SL. (2002) Protein kinase A regulates ?2 integrin
avidity in neutrophils. J Leukoc Biol 71:1042-1048.
Jones SL, Sharief Y, Chilcoat CD. (2001) Signaling
mechanism for equine neutrophil activation by immune
complexes. Vet Immunol Immunopath 82:87-100.
Jones SL, Blikslager AT. (2001) Future directions in
anti-inflammatory therapy. Vet Clin North Am Equine
Pract 17:245-262.
Gayle JM, Blikslager AT, Jones SL. (2000) Role of
neutrophils in intestinal mucosal injury. J Am Vet
Med Assoc 217:498-500.
Jones SL, Wang J, Turck CW, Brown EJ. (1998) A role
for the actin-bundling protein L- plastin in the regulation
of leukocyte integrin function. Proc Natl Acad Sci,USA.
95:9331-9336.
Jones SL, Knaus UG, Bokoch GM, Brown EJ. (1998) Two
signaling mechanisms for activation of ?M ?2 avidity
in polymorphonuclear neutrophils. J Biol Chem. 273:10556-10566.
Jones SL, Brown EJ. (1996) Fc?RII-mediated adhesion
and phagocytosis induce L-plastin phosphorylation
in human neutrophils. J Biol Chem. 271:14623-14630.
Rosales C, Jones SL, McCourt D, Brown EJ. (1994) Bromophenacyl
bromide binding to the actin-bundling protein l-plastin
inhibits inositol triphosphate-independent increase
in Ca2+ in human neutrophils. Proc Natl Acad Sci USA.
91:3534-3538.
Jones SL, Lindberg FL, Brown EJ. (1999) Phagocytosis.
In: Paul WE (ed). Fundamental Immunology. Raven Press,
New York, NY. pp 997-1020.
Jones SL, Brown EJ. Functional cooperation between
Fc receptors and complement receptors in phagocytes.
In: van de Winkel JGJ, Capel PJA (eds). Human IgG
Fc Receptors RG Landes Co, Georgetown, Texas, 1996.
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