Faculty

Marlene Hauck, DVM, PhD
Associate Professor, Oncology

Doctor of Veterinary Medicine, Colorado State University
Doctor of Philosophy, Duke University
Diplomate, American College of Veterinary Internal Medicine (Oncology)

Phone: 919.513.8274
Fax: 919.513.6336
Email: marlene_hauck@ncsu.edu

Specialty

• Treatment of solid and hematopoietic tumors
• Clinical trials of novel therapeutic agents

Professional Experience & Qualifications

Research Area

• Targeted therapeutics
• Hyperthermia Clinical Trials

Selected Publications

Phillips JC, Stephenson B, Hauck M, Dillberger J. Heritability and segregation analysis of osteosarcoma in the Scottish deerhound. Genomics 2007;90(3):354-63.

Siddiqui F, Li C-Y, LaRue SM, Poulson JM, Avery PR, Pruitt AF, Zhang X, Ullrich RL, Thrall DE, Dewhirst MW, Hauck ML.  A phase I trial of hyperthermia-induced interleukin-12 gene-therapy in spontaneously arising feline soft tissue sarcomas.  Molecular Cancer Therapeutics 2007;6(1):380-389.

Hauck ML, LaRue SM, Petros WP, Poulson JM, Yu D,  Spasojevic I, Pruitt AF, Klein A, Case B, Thrall DE, Needham D, Dewhirst  MW.  Phase I Trial of Doxorubicin-Containing Low-Temperature Sensitive Liposomes in Spontaneous Canine Tumors. Clinical Cancer Research 2006;12(13):4004-4010.

Kleiter MM, Yu D, Mohammadian LA, Niehaus N, Spasojevic I, Sanders L, Viglianti BL, Pavel S.Yarmolenko PS, Hauck M, Petry NA, Wong TZ, Dewhirst MW, Thrall DE.  A Tracer Dose of Technetium-99m Labeled Liposomes Can Estimate the Effect of Hyperthermia on Intratumoral Doxil Extravasation.  Clinical Cancer Research 2006;12(22):6800-6807.

Heller DA, Stebbins ME, Reynolds TL, Hauck, ML. A retrospective study of canine soft tissue sarcomas: 87 cases (1991-2001).  International Journal of Applied Research in Veterinary Medicine 2005;3(2):81-87.

Hauck ML, Zalutsky MR.  Enhanced tumor uptake of radiolableled antibodies by hyperthermia: Part II: effect of heating protocol. International Journal of Hyperthermia 2005;21(1):13-27.

Hauck ML, Zalutsky MR.  Enhanced tumour uptake of radiolabelled antibodies by hyperthermia: Part I: timing of injection relative to hyperthermia.  International Journal of Hyperthermia 2005;21(1):1-11.

Williams LE, Johnson JL, Hauck ML, Ruslander DM, Price GS, Thrall DE. Chemotherapy followed by half-body radiation therapy for canine lymphoma. Journal of Veterinary Internal Medicine 2004;18(5):703-709.

Proulx DR, Ruslander DM, Dodge RK, Hauck ML, Williams LE, Horn B, Price GS, Thrall DE.  A retrospective analysis of 140 dogs with oral melanoma treated with external beam radiation.  Veterinary Radiology and Ultrasound 2003;44(3):352-359.

Bailey D, Erb H, Williams L, Ruslander D, Hauck M.  Carboplatin and doxorubicin combination chemotherapy for the treatment of appendicular osteosarcoma in the dog.  Journal of Veterinary Internal Medicine 2003;17(2):199-205.

Kobayashi TK, Hauck ML, Dodge R, Page RL, Price GS, Williams LE, Hardie EM, Mathews KG, Thrall DE.  Preoperative radiation therapy for vaccine site sarcoma in 92 cats. Veterinary Radiology and Ultrasound 2002;43:473-479.

DeFrancesco TC, Atkins CE, Keene BW, Coats JR, Hauck ML.  Prospective clinical evaluation of serum cardiac troponin T in dogs admitted to a veterinary teaching hospital.  Journal of Veterinary Internal Medicine 2002;16:553-557.

Dickerson ME, Page RL, LaDue TA, Hauck ML, Thrall DE, Stebbins ME, Price GS. Retrospective Analysis of Axial Skeleton Osteosarcoma in 22 Large-Breed Dogs. Journal of Veterinary Internal Medicine 2001;15:120-124.

Case BC, Hauck ML, Yeager RL, Simkins AH, De Serres M, Schmith VD, Dillberger JE, Page RL. The pharmacokinetics and pharmacodynamics of GW395058, a peptide agonist of the thrombopoietin receptor, in the dog, a large-animal model of chemotherapy-induced thrombocytopenia. Stem Cells 2000;18(5):360-365.

Ramirez O, Dodge RK, Page RL, Price GS, Hauck ML, LaDue TA, Nutter F, Thrall DE. Palliative radiotherapy of appendicular osteosarcoma in 95 dogs. Veterinary Radiology and Ultrasound 1999;40(4):517-522.

LaDue TA. Dodge R, Page RL, Price GS, Hauck ML, Thrall DE. Factors influencing survival after radiotherapy of nasal tumors in 130 dogs. Veterinary Radiology and Ultrasound 1999;40:312-317.

Hauck ML, Zalutsky MR. The effects of local hyperthermia on the catabolism of a radioiodinated chimeric monoclonal antibody. Clinical Cancer Research 1998; 4: 2071-2077.

Hauck ML, Larsen RH, Welsh PC, Zalutsky MR. Cytotoxicity of a-particle emitting 211At-labeled monoclonal antibody in tumor spheroids: effect of moderate hyperthermia. British Journal of Cancer 1998;77:753-759.

Hauck ML, Coffin DO, Dodge RK, Dewhirst MW, Mitchell JB, Zalutsky MR. Hyperthermia does not effect tumor interstitial fluid pressure in a human glioma xenograft model. International Journal of Hyperthermia 1997;13:307-316.

Hauck ML, Dewhirst MW, Bigner DD, Zalutsky MR. Local hyperthermia improves uptake of a chimeric monoclonal antibody in a subcutaneous xenograft model. Clinical Cancer Research 1997;3:63-70.

Hauck ML, Price GS, Ogilvie GK, Johnson J, Gillette EL, Thrall DE, Dewhirst MW, Page RL. Phase I evaluation of mitoxantrone alone and combined with whole body hyperthermia in dogs with lymphoma. International Journal of Hyperthermia 1996;12:309-320.

Hauck ML, Dewhirst MW, Zalutsky MR. The effects of clinically relevant hyperthermic temperatures on the kinetic binding parameters of the anti-tenascin monoclonal antibody 81C6. Journal of Nuclear Medicine and Biology 1996;23:551-557.

Hauck ML. Editorial comment. International Journal of Hyperthermia 1996;12:827-829.

Page RL, McEntee MC, Williams PL, George SL, Price GS, Novotney CA, Hauck ML, Riviere JE, Dewhirst MW, Thrall DE. Effect of whole body hyperthermia on carboplatin disposition and toxicity in dogs. International Journal of Hyperthermia 1994;10:807-816.

Thrall DE, McEntee MC, Novotney C, Hauck ML, Page RL. A boost technique for irradiation of malignant canine nasal tumors. Veterinary Radiology and Ultrasound 1993;34(4):295-300.

Page RL, Thrall DE, George SL, Price GS, Heidner GL, McEntee MC, Novotney CA, Hauck ML, Dewhirst MW. Quantitative estimation of the thermal dose-modifying factor for Dis-diamminedichloroplatinum (CDDP) in tumor-bearing dogs. International Journal of Hyperthermia 1992; 8(6):761-769.

Book Chapters

Hauck ML. Injection site sarcomas. In Kitchell BE (ed) Veterinary Clinics of North America-Update in Medical Oncology. W. B. Saunders, Philadephia, PA, May 2003, 553-571.

Hauck ML, Dewhirst MW, Zalutsky MR. Enhancement of radiolabeled monoclonal antibody uptake in tumors with local hyperthermia. In Torchilin VP (ed) Handbook of Targeted Delivery of Imaging Agents. CRC Press, Boca Raton, FL, 1995, 333-359.

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