Faculty

Nancy Monteiro-Riviere, PhD
Professor, Investigative Dermatology and Toxicology
Adjunct Professor, Department of Dermatology, School of Medicine, University of North Carolina at Chapel Hill

PhD: 1981 Purdue University, Veterinary Anatomy and Cell Biology
Postdoctoral Fellow Toxicology: 1982-1984: Chemical Industry Institute of Toxicology, Research Triangle Park, NC.

Phone: 919.513.6426
FAX: 919.513.6358
Email: nancy_monteiro@ncsu.edu

Specialty

Nanotoxicology, Dermatotoxicology, Percutaneous Absorption, and Novel Transcutaneous Drug Delivery.

Professional Experience & Qualifications

Elected as a Fellow - The Academy of Toxicological Sciences
American College of Toxicology
American Academy of Nanomedicine
BS Cum Laude
Diplomate of the American Board of Forensic Examiners
Diplomate of the American Board of Forensic Medicine
Sigma Xi, CIIT Postdoctoral Fellowship Award, International Life Sciences Institute of Pathology/Toxicology Expert, Phi Zeta National Veterinary Medicine Honor Society 2001

Editorial Boards:
1995-1996 Microscopy Research and Techniques (Guest Editor)
Topical Issue on Dermatotoxicology, 1992-1998
Fundamental and Applied Toxicology, 1998-2000
Toxicological Sciences, 1997-present
Toxicology Methods, 2000-present
Journal of Applied Toxicology, 2001-present
Journal of Toxicology Cutaneous and Ocular Toxicology, 2002-present
Toxicology Mechanisms and Methods, 2003-present, Toxicology In Vitro
Grant Reviewer: American Institute of Biological Sciences, United States Army Medical Research and Materiel Command, National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Scientific Advisory Committee on Alternative Toxicological Methods
HESI, ILSI Health and Environmental Science Institute

Research Area

My research program focuses on the toxicity of environmental and novel pharmaceutical compounds. This involves assessing the toxicological effects that topically applied drugs or chemicals have on the skin, dermatotoxicity and absorption in both in vivo and in vitro model systems. Studies are conducted in in vitro pig and human keratinocyte culture systems, diffusion cells, ex vivo isolated perfused skin, and in vivo pig. Recent interest is in the toxicity of nanomaterials, multi-walled carbon nanotube, single-walled carbon nanotubes, quantum dots, and fullerenes.

Also, studies involve studying the pathogenesis and mechanism of toxicity of many environmental compounds such as the molecular mechanisms of chemical vesicants, pesticides, dermatotoxicity and absorption of jet fuels; the effects of electrically assisted transdermal drug delivery systems on skin structure and function, and on developing mechanism-based biomarkers for detecting chemical induced cellular damage to skin. Primarily, pig skin is used as a model because it is similar anatomically, physiologically and biochemically to human skin.

In addition, the role of pro-inflammatory cytokines such as TNF-a, IL-8, prostaglandins and other cytokines as biomarkers to detect the earliest changes of cutaneous inflammation in both in vivo and in vitro models. By using indirect immunoelectron microscopy, immunohistochemistry, western blotting, cell culture and immunofluorescence allows us to probe the effects of vesicants, irritants, nanomaterials and other toxic compounds on skin.

Projects involve assessing the irritation of novel jet fuels (Jet A, JP-8, JP8 (100) for the U.S. Air Force and nanomaterial toxicity in invitro model systems. All of these projects focus on human occupational exposures.

Selected Publications

Yang JH, Lee CH, Monteiro-Riviere NA, Riviere JE, Tsang CL, Chou CC: Toxicity of jet fuel aliphatic and aromatic hydrocarbon mixtures on human epidermal keratinocytes: evaluation based on in vitro cytotoxicity and interleukin-8 release. Archives of Toxicology (In Press).

Rouse JG, Yang J, Barron AR, Monteiro-Riviere NA: Fullerene-based amino acid nanoparticle interactions with human epidermal keratinocytes. Toxicology In Vitro (In Press).

Monteiro-Riviere NA, Inman AO, Barlow BM, Baynes RE: Dermatotoxicity of cutting fluid mixtures: in vitro and in vivo studies. (In Press)

Chou CC, Yang JH, Chen SD, Monteiro-Riviere NA, Li HN, Chen JJ: Expression profiling of human epidermal keratinocyte response following one minute JP-8 exposure. Journal of Cutaneous and Ocular Toxicology  25:141-153,2006.

Ryman-Rasmussen JP, Riviere JE, Monteiro-Riviere NA: Penetration of intact skin by   quantum dots with diverse physicochemical properties. Toxicological Sciences 91:159-165, 2006.

Yang JH, Lee CH, Monteiro-Riviere NA, Riviere JE, Tsang CL, Chou CC: Toxicity of jet fuel aliphatic and aromatic hydrocarbon mixtures on human epidermal keratinocytes: evaluation based on in vitro cytotoxicity and interleukin-8 release. Archives of Toxicology (In Press).

Monteiro-Riviere NA, Hedgepeth V, Inman A, Mosteller B, Piedrahita J: Dermatological effects of chronic exposure to 7,12-dimethylbenz[a]anthracene (DMBA) or N-methyl-n-nitrosoguanidine (MNNG) in swine. Journal of Cutaneous and Ocular Toxicology. (In Press).

Monteiro-Riviere NA: The Integument. In Dellmann's Textbook of Veterinary Histology. (Eds. J Eurell and B Frappier, Sixth Edition). Blackwell Publishing, Ames, Iowa, Chapter 16, pp 320-349, 2006.

Monteiro-Riviere NA, Ryman-Rasmussen JP. Toxicology of Nanomaterials. In        Biological Concepts and Techniques in Toxicology: An Integrated Approach (Ed. JE Riviere) Taylor and Francis Publishers, New York, NY, Chapter 12, pp.217-233, 2006.

Tournas JA, Lin FH, Burch JA, Selim MA, Monteiro-Riviere NA, Zielinski JE, Pinnell SR: Ubiquinone, idebenone and kinetin provide ineffective photoprotection to skin when compared to a topical antioxidant combination of vitamins C and E with ferulic acid. Journal of Investigative Dermatology  126:1185-1187, 2006.

Monteiro-Riviere NA, Inman AO: Challenges for assessing carbon nanomaterial toxicity to the skin.  Carbon  44:1070-1078, 2006.

Van der Merwe D, Brooks JD, Gehring R, Baynes RE, Monteiro-Riviere NA, Riviere JE: A physiological-based pharmacokinetic model of organophosphate dermal absorption. Toxicological Sciences 89:188-204, 2006.

Monteiro-Riviere NA: Structure and Function of Skin. In Dermal Absorption Models in Toxicology and Pharmacology (Ed. JE Riviere). CRC, Taylor and Francis, Boca Raton, FL. Chapter 1. pp.1-19, 2006.

Monteiro-Riviere NA, Riviere JE: The Pig as a Model for Human Skin Research. In "Swine in Biomedical Research: Update on Animal Models". (Eds M Swindle and GF Bouchard) Sinclair Research Center, pp.17-22, 2005.

Ferreira P, Groff R, Haslinger K, Koonce M, Le Duc P, Lee W, Love C, Mc Gammon A, Monteiro-Riviere N, Rotello V, Rubloff G, Westervelt R, Wong M, Yoda M: An in vivo nanofactory: the medicine of the future. National Academies on Designing Nanostructures at the Interface between Biomedical and Physical Systems. The National Academies Press, Washington, DC, pp. 53-60, 2005

Monteiro-Riviere NA, Inman AO, Wang YY, Nemanich RJ: Surfactant effects on carbon nanotube interactions with human epidermal keratinocytes.Nanomedicine: Nanotechnology, Biology and Medicine  1:293-299, 2005.

Holsapple MP, Farland WH, Landry TD, Monteiro-Riviere NA, Carter JM, Walker NJ, Thomas KV: Research Strategies for Safety Evaluation of Nanomaterials: Part 2, Toxicological and safety evaluation of nanomaterials: current challenges and data needs.  Toxicological Sciences 88:  12-17, 2005.

Witzmann FA, Monteiro-Riviere NA, Inman AO, Kimpel MA, Pedrick NM, Ringham HN, Riviere JE: Effect of JP-8 jet fuel exposure on protein expression in human keratinocyte cells in culture. Toxicology Letters 160:8-21, 2005.

Oberdorster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman K, Carter J, Karn B, Kreyling W, Lai D, Olin S, Monteiro-Riviere N, Warheit D, Yang H: Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Particle and Fibre Toxicology  2:8, 1-35, 2005.

Lin FH, Lin JY, Gupta RD, Tournas JA, Burch JA, Selim MA, Monteiro-Riviere NA, Grichnik JM, Zielinski J, Pinnell SR:  Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. Journal of Investigative Dermatology 125:826-832, 2005.

Monteiro-Riviere NA, Nemanich RJ, Inman AO, Wang YY, Riviere JE: Multi-walled carbon nanotube interactions with human epidermal keratinocytes. Toxicology Letters 155:377-384, 2005.

Xia XR, Baynes RE, Monteiro-Riviere NA, Riviere JE. Determination of the partition coefficient and absorption kinetic parameters of chemicals in a lipophilic membrane/water system by using a membrane-coated fiber technique. European Journal of Pharmaceutical Sciences: 15-23, 2005.

Muhammad F, Monteiro-Riviere NA, Riviere JE: Comparative in vivo of topical JP-8 jet fuel and its individual hydrocarbon components: Identification of tridecane and tetradecane as key constituents responsible for dermal irritation. Toxicologic Pathology 33:258-266, 2005.

Muhammad F, Monteiro-Riviere NA, Baynes RE, Riviere JE. Effect of in vivo jet fuel exposure on subsequent in vitro dermal absorption of individual aromatic and aliphatic hydrocarbon fuel constituents. Journal of Toxicology and Environmental Health Part A, 68:719-737, 2005.

Xia XR, Baynes RE, Monteiro-Riviere NA, Riviere JE: Membrane uptake kinetics of jet fuel aromatic hydrocarbons from aqueous solutions studied by a membrane-coated fiber technique.  Toxicology Mechanisms and Methods 15: 307-316, 2005.

Udomkusonsri P, Noga EJ, Monteiro-Riviere NA: Pathogenesis of acute ulceration response (AUR) in hybrid striped bass. Diseases of Aquatic Organisms  61: 199-213, 2004.

Riviere JE, Baynes RE, Monteiro-Riviere NA, Smith CE: Quantitating absorption of complex chemical mixtures. Final Report, CDC OH 007555, pp.1-27, 2004.

Lin JY, Lin FH, Burch JA, Selim MA, Monteiro-Riviere NA, Grichnik JM, Pinnell SR:  ? -Lipoic acid is ineffective as a topical antioxidant for photoprotection of skin. Journal of Investigative Dermatology 123: 996-998, 2004.

Xia XR, Baynes RE, Monteiro-Riviere NA, Riviere JE: Characterization of polyacrylate membrane-coated fibers used in chemical absorption studies with programmed thermal treatment and FT-IR microscopy.  Analytical Chemistry  76: 4245-4250, 2004.

Xia XR, Baynes RE, Monteiro-Riviere NA, Riviere JE:  A compartment model for the membrane-coated fiber (MCF) technique used for determining the absorption parameters of chemicals through lipophilic membranes. Pharmaceutical Research  21: 1345-1352, 2004.

Monteiro-Riviere NA, Inman A, Riviere JE: Skin toxicity of jet fuels: ultrastructural studies and the effects of substance P.  Toxicology and Applied Pharmacology  195: 339-347, 2004.

Muhammad F, Baynes RE, Monteiro-Riviere NA, Xia XR, Riviere JE: Dose related absorption of JP-8 jet fuel hydrocarbons through porcine skin with quantitative structure permeability relationship analysis. Toxicology Mechanisms and Methods 14: 159-166, 2004.

Monteiro-Riviere NA:  Anatomical Factors Affecting Barrier Function. In Dermatotoxicology, 6th Edition  (Eds. H. Zhai, and HI Maibach), CRC Press, Washington, DC, Chapter 4, pp.42-70, 2004.

Monteiro-Riviere NA, Chou CC, Riviere JE: Dose related interleukin-8 release from epidermal keratinocytes after exposure to jet fuel aromatic hydrocarbons. Journal of Veterinary Pharmacology and Therapeutics 26 (Suppl.1), 162, B26 (0100) 2003. 

Chou CC, Riviere JE, Monteiro-Riviere NA: The cytotoxicity of jet fuel aromatic  hydrocarbons and dose-related interleukin-8 release from human epidermal keratinocytes. Archives of Toxicology  77: 384-391, 2003.

Inman AO, Still KR, Jedeberg WW, Carpenter RL, Riviere JE, Brooks JD, Monteiro-Riviere NA: Percutaneous absorption of 2,6-di-tert-butyl-4-nitrophenol (DBNP) in isolated perfused porcine skin. Toxicology in Vitro 17:289-292, 2003.

Lin JY, Selim MA, Shea CR, Grichnik JM, Omar MM, Monteiro-Riviere NA, Pinnell SR: UV photoprotection by combination topical antioxidants vitamin C and vitamin E. Journal of the American Academy of Dermatology  48: 866-874, 2003.

Xia XR, Baynes RE, Monteiro-Riviere NA, Leidy RB, Shea D, Riviere JE: A novel in vitro technique for studying percutaneous permeation with a membrane-coated fiber and gas chromatography / mass spectrometry. Part I. Performance of the technique and determinations of the permeation rates and partition coefficients of chemical mixtures. Pharmaceutical Research 20:275-282, 2003.

Riviere JE, Baynes RE, Brooks JD, Yeatts JL, Monteiro-Riviere NA: Percutaneous absorption of topical diethyl-m-toluamide (DEET): Effects of exposure variables and co-administered toxicants. Journal of Toxicology and Environmental Health, Part A  66:133-151, 2003.

Monteiro-Riviere NA, Van Miller JP, Simon GS, Joiner RL, Brooks J, Riviere JE:  In vitro percutaneous absorption of nonylphenol (NP) and nonylphenol ethoxylates NPE-4 and NPE-9 in isolated perfused skin. Journal of Toxicology-Cutaneous and  Ocular Toxicology 22: 1-11, 2003.

Monteiro-Riviere NA, Baynes RE, Riviere JE: Pyridostigmine bromide modulates topical irritant-induced cytokine release from human epidermal keratinocytes and isolated perfused skin. Toxicology  183: 15-28, 2003.

Riviere JE, Monteiro-Riviere NA, Baynes RE: Gulf War related exposure factors influencing topical absorption of 14C -permethrin. Toxicology Letters  135: 61-71, 2002.

Chou CC, Riviere JE, Monteiro-Riviere NA: Differential relationship between carbon chain-length of jet fuel aliphatic hydrocarbons and their ability to induce cytotoxicity versus interleukin-8 release in human epidermal keratinocytes. Toxicological Sciences  69: 226-233, 2002.

Riviere JE, Monteiro-Riviere NA, Baynes RE: Percutaneous absorption of chemical mixtures relevant to the Gulf War. Final Report. USAMRMC DAMD17-99C-9047 Technical Report, pps, 1-162, 2002.

Baynes RE, Monteiro-Riviere NA, Riviere JE: Pyridostigmine bromide modulates the dermal disposition of 14C-permethrin. Toxicology and Applied Pharmacology 181: 164-173, 2002.

Rhyne BN, Pirone JR, Monteiro-Riviere NA: The use of enzyme histochemistry in detecting cutaneous toxicity of three topically applied jet fuel mixtures. Toxicology Mechanisms and Methods 12: 17-34, 2002.

Monteiro-Riviere NA, Inman AO, Jackson H, Dunn B, Dimond S: Efficacy of topical phenol decontamination strategies on the severity of acute phenol chemical burns and dermal absorption: in vitro and in vivo studies in pig skin. Toxicology and Industrial Health 17: 95-104, 2001.

Baynes RE. Riviere JE, Smith CE, Monteiro-Riviere NA, Freeman B: Dermal absorption cutting fluids. Annual Report. 1R010H03669-01A2, May 2001.

Riviere JE, Baynes RE, Smith CE, Monteiro-Riviere NA: Quantitating the percutaneous absorption of mechanistically defined chemical mixtures. AFOSR GF 49620-98-1-0105, NTIS Report, pps.1-109, 2001.

Riviere JE, Monteiro-Riviere, NA, Baynes RE: Percutaneous absorption of chemical mixtures relevant to the Gulf War. Annual Report. USAMRMC, DAMD17-99-C-9047, Technical Report ADB, pps.1-34, 2001.

Allen DA, Riviere JE, Monteiro-Riviere NA: Analysis of interleukin-8 release from normal human epidermal keratinocytes exposed to aliphatic hydrocarbons: delivery of hydrocarbons to cell cultures via complexation with a-cyclodextrin. Toxicology In Vitro 15: 663-669, 2001.

Inman AO, Olivry T, Dunston, SM, Gatto H and Monteiro-Riviere NA: Electron microscopic observations of stratum corneum intercellular lipids in normal and atopic dogs. Veterinary Pathology 38:720-723, 2001.

Monteiro-Riviere NA, Inman AO, Riviere JE: The effects of short-term high dose and low dose dermal exposure to Jet A, JP-8, and JP-8+100 jet fuels. Journal Applied Toxicology  21:485-494, 2001.

Allen DG, Riviere JE, Monteiro-Riviere NA: Cytokine induction as a measure of cutaneous toxicity in primary and immortalized porcine keratinocytes exposed to jet fuels, and their relationship to normal human epidermal keratinocytes. Toxicology Letters 119: 209-217, 2001.

Monteiro-Riviere NA, Inman AO, Mak V, Wertz P, Riviere JE: Effect of selective lipid extraction from different body regions on epidermal barrier function. Pharmaceutical Research 18:992-998, 2001.

Monteiro-Riviere NA: Dermatotoxicology. In An Introduction to Biochemical Toxicology, (Ed. E. Hodgson and RC Smart), 3rd ed., John Wiley and Sons, NY. Chapt. 21, 509-537, 2001.

Pinnell SR, Yang H, Omar M, Monteiro-Riviere NA, DeBuys HV, Walker LC, Wang Y, Levine M. Topical L-ascorbic acid: Percutaneous absorption studies. Dermatological Surgery 27:137-142, 2001.

Riviere JE, Smith CE, Budsaba K, Brooks JD, Olajos EJ, Salem H and Monteiro-Riviere NA. Use of methyl salicylate as a simulant to predict the percutaneous absorption of sulfur mustard. Journal Applied Toxicology 21: 91-99, 2001.

Monteiro-Riviere NA: The Integument. In The Biology of the Domestic Pig, (Eds. W G Pond and HJ Mersmann), Cornell University Press, Ithaca, NY. Chapt. 14, 625-652, 2001.

Allen DA, Riviere JE, Monteiro-Riviere NA: Identification of early biomarkers of inflammation produced by keratinocytes exposed to jet fuels Jet A, JP8 and JP8-100. Journal of Biochemical and Molecular Toxicology 14:231-237, 2000.

Monteiro-Riviere NA, Van Miller JP, Simon G, Joiner RL, Brooks JD, Riviere JE Comparative in vitro dermal absorption of nonylphenol and nonylphenol ethoxylates (NPE-4 and NPE-9) through human, porcine and rat skin. Toxicology and Industrial Health 16:1-9, 2000.

Monteiro-Riviere NA, Inman AO: Characterization of sulfur mustard-induced toxicity by enzyme histochemistry in porcine skin. Toxicology Methods 10:1-16,2000.

Riviere JE, Brooks JD, Monteiro-Riviere NA: Dermal absorption and distribution of topically dosed jet fuels JET-A, JP-8, and JP-8 (100). Toxicology and Applied Pharmacology 160: 60-75, 1999.

Monteiro-Riviere NA, Inman AO, Babin MC, Casillas RP: Immunohistochemical characterization of the basement membrane epitopes in bis (2-chloroethyl) sulfide induced toxicity in mouse ear skin. Journal Applied Toxicology 19: 313-328, 1999.

Monteiro-Riviere NA and Riviere JE: Skin Toxicology In Toxicology, (Eds. H Marquardt, S Schäfer, R McClellan, F Welsch), Academic Press, San Diego, CA, Chapt. 18, 439-457, 1999.

Allen DA, Monteiro-Riviere NA: Alteration of cytokeratin expression following transdermal lidocaine hydrochloride iontophoresis. Pharmaceutical Research 16: 1487-1490, 1999.

Monteiro-Riviere NA: The Integument. In Textbook of Veterinary Histology. (Ed. H Dieter-Dellman and J Eurell). Williams & Wilkins, Media, Pa. Chapter 16, pp. 303-332, 1998.

Zhang Z, Fine JD, Monteiro-Riviere NA: Uncein may be a potential target for sulfur mustard alkylation. Toxicology Methods 8: 27-36,1998.

Baynes RE, Monteiro-Riviere NA, Qiao GL, Riviere JE: Cutaneous toxicity of the benzidine dye direct red 28 as a mechanistically- defined chemical mixture (MDCM) in perfused porcine skin. Toxicology Letters 93: 159-169,1997.

Zhang Z, Monteiro-Riviere NA: Comparison of integrins in human skin, pig skin, and perfused skin: an in vitro skin toxicology model. Journal of Applied Toxicology 17: 247-253, 1997.

Monteiro-Riviere NA, Inman AO: Ultrastructural characterization of sulfur mustard-induced vesication in isolated perfused porcine skin. Microscopy Research and Technique 37: 229-242, 1997.

Monteiro-Riviere NA, Inman AO, Snider TH, Blank J, Hobson DW: Comparison of an in vitro skin model to normal human skin for dermatological research. Microscopy Research and Technique 37: 172-179, 1997.

Monteiro-Riviere NA, Riviere JE: The Pig As A Model For Cutaneous Pharmacology and Toxicology Research. In Swine In Biomedical Research, (Eds. ME Tumbleson and LB Schook), Plenum Publishing Corporation, New York, NY, Vol. II, Chapt. 38, 425-458, 1996.

Monteiro-Riviere NA: Anatomical Factors Affecting Percutaneous Absorption. In Dermatotoxicology, 5th Edition (Eds. Marzulli FN and HI Maibach), Taylor and Francis, Washington, DC, pp.3-17, 1996.

Riviere JE, Monteiro-Riviere NA, Rogers RA, Bommannan D, Tamada JA, Potts RO: Pulsatile transdermal delivery of LHRH using electroporation: Drug delivery and skin toxicology. Journal of Controlled Release 36:229-233, 1995.

Riviere JE, Brooks JD, Williams PL, Monteiro-Riviere NA: Toxicokinetics of topical sulfur mustard penetration, disposition, and vascular toxicity in isolated perfused porcine skin. Toxicology and Applied Pharmacology 135:25-34, 1995.

Zhang JZ, Peters BP, Monteiro-Riviere NA: Assessment of sulfur mustard interaction with basement membrane components. Cell Biology and Toxicology 11: 89-101, 1995.

Zhang JZ, Riviere JE, Monteiro-Riviere NA: Topical sulfur mustard induces changes in prostaglandins and interleukin-1a in isolated perfused porcine skin. In Vitro Toxicology 8: 149-158, 1995.

Monteiro-Riviere NA and Inman AO: Indirect immunohistochemistry and immunoelectron microscopy distribution of eight epidermal-dermal junction epitopes in the pig and in isolated perfused skin treated with bis (2-chloroethyl) sulfide. Toxicologic Pathology 23:313-325, 1995.

Spoo JW, Monteiro-Riviere NA, Riviere JE: Detection of sulfur mustard (bis-2-chloroethyl sulfide) and metabolites after topical application in the isolated perfused porcine skin flap. Life Sciences 56: 1385-1394, 1995.

Chang SK, Brooks, JD, Monteiro-Riviere NA, Riviere JE: Enhancing or blocking effect of fenvalerate on the subsequent percutaneous absorption of pesticides in vitro. Pesticide Biochemistry and Physiology 51: 214-219, 1995.

Zhang JZ, Riviere JE, Monteiro-Riviere NA: Evaluation of protective effects of sodium thiosulfate, cysteine, niacinamide, and indomethacin on sulfur mustard-treated isolated perfused porcine skin. Chemico-Biological Interactions 96:249-262,1995.

Monteiro-Riviere NA, Inman AO, Riviere JE: Development and characterization of a novel skin model for cutaneous phototoxicology. Photodermatology, Photoimmunology, and Photomedicine 10:235-243, 1994.

King JR, Peters BP, Monteiro-Riviere NA: Matrix molecules of the epidermal basement membrane as targets for chemical vesication with lewisite. Toxicology and Applied Pharmacology 126: 164-173, 1994.

Meyer SA, Kim TW, Moser GJ, Monteiro-Riviere NA, Smart RC: Synergistic interaction between the non-phorbol ester type promoter mirex and 12-O-tetradecanoylphorbol-13-acetate in mouse skin tumor promotion. Carcinogenesis: 15: 47-52, 1994.

Monteiro-Riviere NA, Inman AO, Riviere JE: Identification of the pathway of electrically assisted transdermal drug delivery: light and ultrastructural studies using mercuric chloride in pigs. Pharmaceutical Research 11: 251-256, 1994.

Meyer SA, Moser GJ, Monteiro-Riviere NA, Smart RC: Minimal role of enhanced cell proliferation in skin tumor promotion by mirex, a new nonphorbol ester-type promoter. Environmental Health Perspectives 101 (Suppl 5): 265-270, 1993.

Monteiro-Riviere NA, Inman AO, Riviere JE, McNeil SC, Francoeur ML: Topical penetration of piroxicam is dependent on the distribution of the local cutaneous vasculature. Pharmaceutical Research 10:1326-1331, 1993.

Monteiro-Riviere NA: The use of isolated perfused skin in dermatotoxicology. In Vitro Toxicology 5: 219-233, 1993.

King JR, Riviere JE, Monteiro-Riviere NA: Characterization of lewisite toxicity in isolated perfused skin. Toxicology and Applied Pharmacology 116: 189-201, 1992.

Srikrishna V, Riviere JE, Monteiro-Riviere NA: Cutaneous toxicity and absorption of paraquat in porcine skin. Toxicology and Applied Pharmacology 115: 89-97, 1992.

Venkatesh K, Levi PE, Inman AO, Monteiro-Riviere NA, Misra R, Hodgson E: Enzymatic and immunohistochemical studies on the role of cytochrome P450 and the flavin-containing monooxygenase of mouse skin in the metabolism of pesticides and other xenobiotics. Pesticide Biochemistry and Physiology 43:53-66, 1992.

Riviere JE, Monteiro-Riviere NA, Inman AO: Determination of lidocaine concentrations in skin after transdermal iontophoresis: effects of vasoactive drugs. Pharmaceutical Research 9:211-214, 1992.

Monteiro-Riviere NA: Comparative Anatomy, Physiology, and Biochemistry of Mammalian Skin. In Dermal and Ocular Toxicology: Fundamentals and Methods (Ed. DW Hobson). CRC Press, Inc., New York, New York, Chapter 1, pp. 3-71, 1991.

King JR, Monteiro-Riviere NA: Cutaneous toxicity of 2?chloroethyl methyl sulfide in isolated perfused porcine skin. Toxicology and Applied Pharmacology 104:167-179, 1990.

Monteiro-Riviere NA: Specialized Technique: Isolated Perfused Porcine Skin Flap. In Methods for Skin Absorption (Eds. BW Kemppainen and WG Reifenrath). CRC Press, Inc. Chapter 11, pp. 175-189, 1990.

Monteiro-Riviere NA, Bristol DG, Manning TO, Riviere JE: Interspecies and interegional analysis of the comparative histological thickness and laser Doppler blood flow measurements at five cutaneous sites in nine species. Journal of Investigative Dermatology 95:582-586, 1990.

Links

Center for Chemical Toxicology Research and Pharmacokinetics

Return to Top