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Anthony Blikslager, DVM, PhD, DACVS

Anthony Blikslager

Professor, Equine Surgery & Gastroenterology
Phone: 919.513.7725
Fax: 919.513.6717
Email: anthony_blikslager@ncsu.edu

Education

Professional Experience & Qualifications

• Editorial Review Board, Equine Veterinary Journal, 2011-present
• Member, Grayson-Jockey Club Research Foundation Inc., Scientific Advisory Board, 2010-present
• Mentor, NC State Initiative for Maximizing Student Diversity (IMSD), 2010-present
• Chair, Mechanisms and Novel Imaging Modalities of Injury and Repair in the Intestinal Epithelial Barrier, Digestive Disease Week, 2010
• Associate Editor, Equine Veterinary Journal, 2009-2011
• Trainer, NIH T32 (Center for Gastrointestinal Biology and Disease, 2000-present; Center for Comparative Medicine and Translational Research, 2008-present)
• Founding Member, Sucampo Advisory Panel, 2008-present
Editorial Review Board, American Journal of Veterinary Research, 1999-2002; 2007-2010
• Diplomate, American College of Veterinary Surgeons, 1995
• Resident, Large Animal Surgery, July 1990-July 1994, North Carolina State University, College of Veterinary Medicine, Raleigh, NC
• Intern, Equine Medicine and Surgery, June 1989-June 1990, University of Missouri, Equine Center, Columbia, MO

Honors

Congress Hyderabad• Applied Equine Research Award, World Equestrian Veterinary Association, Hyderabad, India, 2011
• Inducted as a Fellow of the American Gastroenterological Association, 2010
• Pfizer Award for Excellence in Research, College of Veterinary Medicine, North Carolina State University, 2006

Research Area

Gastrointestinal Physiology, studying mechanisms responsible for maintenance and restoration of the intestinal barrier, with the ultimate objective of pharmacologically restoring the mucosal barrier in patients suffering from diseases associated with increased intestinal permeability. Restoring the intestinal barrier would be of particular significance in patients suffering from diseases such as intestinal ischemia/reperfusion injury, inflammatory bowel diseases, and gastric ulcer disease because of the potential medical complications associated with these diseases.

Selected Publications

journal coverNighot PK, Blikslager AT. The chloride channel ClC-2 modulates tight junction barrier function via intracellular trafficking of occludin. Am J Physiol Cell Physiol 2012;302:C178-87. (Right - Pictured on journal cover)

Marshall JF, Bhatnagar AS, Bowman SG, Morris NN, Skorich DA, Redding CD, Blikslager AT. The effects of a novel anti-inflammatory compound (AHI-805) on cyclooxygenase enzymes and the recovery of ischaemia injured equine jejunum ex vivo. Equine Vet J 2011;43 Suppl 39:106-11.

Grosche A, Morton AJ, Graham AS, Sanchez LC, Blikslager AT, Polyak MM, Freeman DE Ultrastructural changes in the equine colonic mucosa after ischaemia and reperfusion. Equine Vet J 2011;43 Suppl 39:8-15.

Marshall JF, Bhatnagar AS, Bowman SG, Howard CM, Morris NN, Skorich DA, Redding CD, Blikslager AT. Evaluation of the cyclooxygenase selectivity of robenacoxib and its effect on recovery of ischaemia-injured jejunal mucosa in horses. Am J Vet Res 2011;72:226-32.

Vainio KM, Sykes BW, Blikslager AT. Primary gastric impaction in horses: A retrospective study of 20 cases (2005-2008). Equine Vet Educ 2011;23:186-90.

Bowman SG, Marshall JF, Blikslager AT. Demographic characteristics of horses donated to the North Carolina State University Equine Health Center, 1996-2008. J Am Vet Med Assoc 2010;236:1334-7.

Wooten JG, Lascelles BD, Cook VL, Law JM, Blikslager AT. Evaluation of the relationship between lesions in the gastroduodenal region and cyclooxygenase expression in clinically normal dogs. Am J Vet Res 2010;71:630-5.

Nighot PK, Blikslager AT. ClC-2 regulates mucosal barrier function associated with structural changes to the villus and epithelial tight junction. Am J Physiol Gastrointest Liver Physiol 2010;299:G449-56.

Smith F, Clark JE, Overman BL, Tozel CC, Huang JH, Rivier JE, Blikslager AT, Moeser AJ. Early Weaning Stress Impairs Development of Mucosal Barrier Function in the Porcine Intestine. Am J Physiol Gastrointest Liver Physiol 2010;298:G352-G363.

Nighot PK, Moeser AJ, Ryan KA, Ghashghaei T, Blikslager AT. ClC-2 is required for rapid restoration of epithelial tight junctions in ischemic-injured murine jejunum. Exp Cell Res. 2009;315:110-8.

Cook VL, Jones Shults J, McDowell MR, Campbell NB, Davis JL, Marshall JF, Blikslager AT. Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses. Am J Vet Res. 2009;70:1259-68.

Wooten JG, Blikslager AT, Marks SL, Law JM, Graeber EC, Lascelles BD. Effect of nonsteroidal anti-inflammatory drugs with varied cyclooxygenase-2 selectivity on cyclooxygenase protein and prostanoid concentrations in pyloric and duodenal mucosa of dogs. Am J Vet Res. 2009;70:1243-9.

Cook VL, Meyer CT, Campbell NB, Blikslager AT. Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum. Am J Vet Res. 2009;70:992-1000.

Cook VL, Shults JJ, McDowell MR, Campbell NB, Davis JL, Marshall JF, Blikslager AT. Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses. Am J Vet Res 2009;70:1259-1268.

Books and Book Chapters

Blikslager AT, Marshall JM. Principles of Intestinal Injury and Determination of Intestinal Viability. In: Auer JA, Stick JA, eds, Equine Surgery. Missouri, Saunders Elsevier, 2012, pp. 411-415.

Marshall, JM, Blikslager AT. Colic: Diagnosis, Surgical Decision, and Preoperative Management, In: Auer JA, Stick JA, eds, Equine Surgery. Missouri, Saunders Elsevier, 2012, pp. 402-406.

Wilson DA, Blikslager AT. Stomach and Spleen. In Auer JA, Stick JA, eds, Equine Surgery. Missouri, Saunders Elsevier, 2012, pp. 388-401.

Blikslager AT. Obstructive disorders of the gastrointestinal tract. In: Reed SM, Bayly WM, Sellon DC, Eds., Equine Internal Medicine, Saunders Elsevier, Philadelphia, 2010, pp. 882-892.

Blikslager AT. Ischemic disorders of the intestinal tract. In: Reed SM, Bayly WM, Sellon DC, Eds., Equine Internal Medicine, Saunders Elsevier, Philadelphia, 2010, pp. 876-882.

Blikslager AT. Pathophysiology of mucosal injury and repair. In: Reed SM, Bayly WM, Sellon DC, Eds., Equine Internal Medicine, Saunders Elsevier, Philadelphia, 2010, pp. 794-802.

Blikslager AT. Alimentary diseases. In: Taylor FGR, Brazil T, Hillyer MH, eds., Diagnostic Techniques in Equine Medicine, W.B. Saunders, Philadelphia, PA, 2009, pp. 20-63.

Blikslager AT. Pathophysiology of gastrointestinal disease: obstruction and strangulation. In White NA, Moore JN, Mair TS, Eds., Equine Acute Abdomen, Teton New Media, Jackson, WY, 2009, pp. 100-107.

Links

Gastrointestinal Physiology Laboratory