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Brian Gilger, DVM, MS, Dipl. ACVO, Dipl. ABT

Brian Gilger

Professor, Ophthalmology
Phone: 919.513.1273
Fax: 919.513.6711
Email: brian_gilger@ncsu.edu

Education

Dr. Gilger is a native of Akron, Ohio and received his veterinary degree from the Ohio State University in Columbus, Ohio. After a one-year internship at the Animal Medical Center in New York City, Dr. Gilger worked in a general small animal practice in Atlanta, Georgia. Following a 3 year ophthalmology residency and masters degree at Auburn University in Alabama, Dr. Gilger returned to the Ohio State University as an Assistant Professor of Ophthalmology In 1992. In October 1995, Dr. Gilger joined the faculty at NC State University. His clinical interests include intraocular surgery such as cataract surgery, dry eye treatment and equine ocular disorders. His main research interest is ocular pharmacology, drug delivery, and ocular immunology. Brian and his wife Elizabeth have a daughter, Katherine, and he enjoys running and training for marathons.

Clinical Specialty

Ophthalmology, including equine ocular disorders, uveitis (equine recurrent uveitis), immune-mediated ocular disease, and intraocular surgery such as cataract surgery.

Professional Experience & Qualifications

Research Interests and Expertise

Ocular immunology, inflammation, toxicology, pharmacology, sustained ocular drug delivery.

In the Comparative Ophthalmology Research Laboratory, we study the pathogenesis of ocular immunologic and inflammatory disorders and have developed innovative methods to treat these potentially blinding diseases. We have been especially interested in the study of ocular toxicology and pharmacology of several medications. We study the two main causes of blindness in horses in the southern United States, equine recurrent uveitis and fungal keratitis. We are also interested in studying these naturally-occurring diseases, since they are models of common human diseases. Recently, we have explored methods to deliver therapeutic levels of medications to the eye for extended periods of time using micro-implant and sustained release injection technology.

Recent and Selected Peer-Reviewed Publications (out of 100)

Davis DL, Yi NY, Salmon JH, Charlton AN, Colitz CMH, Gilger BC. Sustained-release celecoxib from incubated acrylic intraocular lenses suppress lens epithelial cell growth in an ex vivo model of posterior capsule opacity (PCO). Invest Ophthalmol Vis Sci (Submitted 2011) (*Gilger corresponding author)

Seiler GS, Salmon JH, Mantuo R, Feingold S, Dayton PA, Gilger BC. Distribution of contrast after injection into the anterior suprachoroidal space using 2D and 3D ultrasound in pig eyes. Invest Ophthalmol Vis Sci 2011 (In press)

Clode AB, Davis J, Davidson G, Jacklyn H. Salmon, Lefevers H, Gilger BC. Aqueous humor and plasma concentrations of a compounded 0.2% solution of terbinafine following topical ocular administration to normal equine eyes. Am J Vet Res 2011;14(1):41-47.

Edelhauser H, Rowe-Rendleman CL, Robinson MR, Dawson DG, Chader GJ, Grossniklaus HE, Rittenhouse KD, Weber DA, Kuppermann BD, Csaky KG, Olsen TW, Kompella UB, Holers VM, Hageman GS, Gilger BC, Campochiaro PA, Whitcup SM, Wong W. Ophthalmic drug delivery systems for the treatment of retinal diseases: basic research to clinical applications. Invest Ophthalmol Vis Sci 2010; 51(11):5403-5420.

Gilger BC, Wilkie DA, Clode AB, McMullen RJ, Utter M, Komaromy A, Brooks DE, Salmon JH. Long-term outcome after implantation of a suprachoroidal cyclosporine drug delivery device in horses with recurrent uveitis. Vet Ophthalmol 2010;13(5):294-300.

Wiener AL, Gilger BC. Advancements in Ocular Drug Delivery. Vet Ophthalmol 2010;13(6):395-406.

Velagaleti PR, Anglade E, Khan IJ, Gilger BC, and Mitra AK. Topical delivery of hydrophobic drugs using a novel mixed nanomicellar technology to treat diseases of the anterior and posterior segments of the eye. Drug Delivery Today 2010;10(4):42-47.

Clode AB, Davis JL, Salmon JH, Gilger BC. Aqueous humor and plasma concentrations of ciprofloxacin and moxifloxacin following topical administration to normal equine eyes. Vet Ophthalmol 2010;71(5):564-569.

Yi NY, Salmon JH, Gilger BC. Quantitative differences in mRNA expression of Toll-like receptor (TLR)-2, -4, and -9 in normal equine eyes and eyes with equine recurrent uveitis. Res Vet Sci 2009; 26: 520-52.

McMullen RJ, Davidson MG, Campbell NB, Salmon JH, Gilger BC. Evaluation of 30- and 25-diopter intraocular lens implants in equine eyes after surgical extraction of the lens. Am J Vet Res 2010;71(7):809-816.

Gift BW, English RV, Nadelstein B, Weigt AK, Gilger BC. Comparison of capsular opacification and refractive status after placement of three different intraocular lens implants following phacoemulsification and aspiration of cataracts in dogs. Vet Ophthalmol 2009;12:13-21.

Douglas L, Davis JL, Salmon JH, Yi NY, Gilger BC. Ocular toxicity and pharmacokinetics of intravitreal and subconjuctival injection of rapamycin (sirolimus) in horses. Vet Pharm Ther 2008;31(6):511-516

Yi NY, Davis JL. Salmon JH, Gilger BC. Ocular toxicity and pharmacokinetics of intravitreal injection of triamcinolone in horses. Vet Ophthalmol (*Gilger corresponding author).

Recent Research Presentations and Abstracts

Salmon JH, Charlton AN, Colitz CMH, Gilger BC. Celecoxib-incubated acrylic intraocular lenses suppress lens epithelial growth in a canine ex vivo model of posterior capsule opacity (PCO). Invest Ophthalmol Vis Sci. Abstract. Association for Research in Vision and Ophthalmology Annual Meeting, Ft Lauderdale, FL, May 2011.

Gilger BC, Seiler GS, Salmon JH, Mantuo R, Dayton P. Distribution of contrast after injection into the anterior suprachoroidal space using 2D and 3D ultrasound in pig eyes. Invest Ophthalmol Vis Sci. Abstract. Association for Research in Vision and Ophthalmology Annual Meeting, Ft Lauderdale, FL, May 2011.

Gilger BC, McMullen RJ, Clode AB, Pate DO, Harrington J, Hempstead J. Clinical characteristics and treatment of endothelial immune mediated keratitis in horses. Dorothy Havemeyer Equine Ophthalmology Symposium. West Palm Beach Florida, April 1 – 2, 2011.

Gilger BC, Salmon JH. Effect of acrylic intraocular lenses on experimental lens epithelial cell ingrowth. American College of Veterinary Ophthalmologists, October 2010; San Diego, California.

Yi NY, Salmon JH, Colitz CMH, Gilger BC. A 4-day incubation with celecoxib inhibits lens epithelial cell proliferation in an ex vivo lens capsule model of posterior capsular opacification (pco). American College of Veterinary Ophthalmologists, October 2010; San Diego, California.

Gilger BC, Salmon JH. Ocular posterior segment drug distribution from a single injection into the anterior suprachoroidal space. Invest Ophthalmol Vis Sci. Abstract. Association for Research in Vision and Ophthalmology Annual Meeting, Ft Lauderdale, FL, May 2010.

Books

Equine Ophthalmology, second edition. Edited by Brian C. Gilger, Published by Elsevier Science, In preparation. Expected publication date: September 2010.

Equine Ophthalmology, Edited by Brian C. Gilger, Published by Elsevier Science, February 25, 2005. 400 pages, 400 color photographs.

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