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Sam Jones, DVM, PhD, DACVIM

Sam Jones

Professor of Equine Medicine
Phone: 919.513.7722
Fax: 919.513.6464



Gastrointestinal diseases, Sepsis and Endotoxemia, Infectious and inflammatory diseases

Professional Experience & Qualifications

2009-present: Assistant Head for Equine Programs, Department of Clinical Sciences, NCSU College of Veterinary Medicine
2007-present: Director, Comparative Biomedical Sciences Program
2006-present: Director, Combined DVM/PhD Program
2004-present: Co-Director, Veterinary Scholars Program
2004-2009: Associate Professor of Equine Medicine, NCSU College of Veterinary Medicine
1998 - 2004: Assistant Professor, Equine Medicine, NCSU College of Veterinary Medicine
1998: Research Associate, Department of Molecular Microbiology, Washington University, St. Louis, MO
1992 - 1998: Ph.D, Immunology, Washington University School of Medicine, St Louis, MO
1992: Clinical Instructor, Equine Medicine, University of California, Davis
1989 - 1992: Resident, Equine Internal Medicine, University of California, Davis
1988 - 1989: Intern, Texas A&M University, College Station, TX

Research Area and Interests

Leukocyte Biology Laboratory

My lab investigates how inflammation is triggered and regulated and how inflammation contributes to the pathophysiology of diseases such as colitis, equine colic, sepsis, and endotoxemia.  A primary objective of our work is to understand the cellular and molecular details of cell migration with a focus on the key innate immune cells called neutrophils.  We are particularly interested in how the signaling molecules protein kinase A, phosphatidylinositol 3-kinase, and p38 and the actin binding proteins MARCKS, VASP, and L-Plastin regulate the actin cytoskeleton, integrin function, and signaling during migration of neutrophils and other cells.  We use human and equine primary cells, cell lines, and in vivo models including mice and zebrafish for these studies. Our lab is also studying how inflammation is triggered and pro-inflammatory genes are upregulated in equine leukocytes. We are studying the responses of equine leukocytes to lipopolysaccharide (endotoxin) and current studies include the mechanism upregulating a number of genes in the prostaglandin synthesis cascade, particularly cyclooxygenase-2 and prostaglandin synthase-1. We also collaborate extensively with Dr. Anthony Blikslager to study the effects of neutrophils and inflammatory mediators on intestinal mucosal repair following ischemic injury such as occurs in some forms of equine colic. Our clinical studies include equine Bartonellosis, equine colic, right dorsal ulcerative colitis, and hepatic injury in horses with intestinal diseases.

Lab Members

Laura Neuder (doctoral candidate)
Katie Sheats, DVM, DACVIM (doctoral candidate)
Eui Jae Sung, DVM, MS (doctoral candidate)
Zach McDowell (Undergraduate Scholar)
Jamie Keener (Undergraduate Scholar)

Selected Publications

Basic Research

Eckert RE, Sharief Y, Jones SL. (2009) p38 Mitogen-Activated Kinase (MAPK) is essential for equine neutrophil migration. Vet Immunol Immunopathol 129:181-191.

Neuder LE, Keener JM, Eckert RE, Trujillo JC, Jones SL. (2009) Role of p38 MAPK in LPS induced pro-inflammatory cytokine and chemokine gene expression in equine leukocytes. Vet Immunol Immunopathol 129:192-199.

Cook VL, Neuder LE, Blikslager AT, Jones SL. (2009) The effect of lidocaine on in vitro adhesion and migration of equine neutrophils. Vet Immunol Immunopathol. 129(1-2):137-42.

Lascelles BDX, King S, Roe S, Marcellin-Little, DJ, Jones SL. (2009) Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis. J Orthoped Res. DOI: 10.1002/jor.20864.

Eckert RE, Neuder LE, Park J, Adler KB, Jones SL. (2009) Myristoylated Alanine-Rich C-kinase Substrate (MARCKS) protein regulation of human neutrophil migration. Am J Resp Cell Mol Biol (Epub ahead of print doi:10.1165/rcmb.2008-0394OC).

Chilcoat CD, Sharief Y, Jones SL. (2008) Tonic protein kinase A activity maintains inactive β2 integrins in unstimulated neutrophils by reducing myosin light chain phosphorylation: Role of myosin light chain kinase and Rho kinase. J Leukoc Biol 83:964-71. 

Eckert RE, Neuder LE, Bell JL, Trujillo JC, Jones SL. (2007) The role of p38 mitogen-activated kinase (MAPK) in the mechanism regulating cyclooxygenase gene expression in equine leukocytes. Vet Immunol Immunopathol 118:294-303.

Eckert RE, Jones SL.  (2007) Regulation of VASP serine 157 phosphorylation in human neutrophils after stimulation by a chemoattractant. J Leukoc Biol 82:1311-21.

Zadrozny LM, Stauffer SH, Armstrong MU, Jones SL, Gookin JL. (2006) Neutrophils do not mediate the pathophysiological sequelae of C. parvum infection in neonatal piglets. Infect Immun 74:5497-5505.

Jones SL, Sharief Y. (2005) Asymmetrical protein kinase A activity establishes neutrophil cytoskeletal polarity and enables chemotaxis. J Leukoc Biol 78:248-258.

Martens RJ, Cohen ND, Jones SL, Moore TA, Edwards JF. (2005) Protective role of neutrophils in mice experimentally infected with Rhodococcus equi. Infect Immun 73:7040-7042.

Shifflett DE, Jones SL, Moeser AJ, Blikslager AT. (2004) Mitogen activated protein kinases regulate COX-2 and mucosal recovery in ischemic-injured porcine ileum. Am J Physiol Gastrointest Liver Physiol 286: G906-G913.

Shifflett DE, Bottone FG Jr, Young KM, Moeser AJ, Jones SL, Blikslager AT. (2004) Neutrophils augment recovery of porcine ischemia-injured ileal mucosa by an IL-1b and COX-2 dependent mechanism. Am J Physiol Gastrointest Liver Physiol 287:G50-G57

Little D, Dean RA, Young KM, McKane SA, Martin LA, Jones SL, Blikslager AT. (2003) Phosphatidyl-3-kinase (PI3'K) signaling is required for prostaglandin-induced mucosal recovery in ischemia-injured porcine ileum. Am J Physiol Gastrointest Liver Physiol 284(1):G46-G56.

Campbell NB, Jones SL, Blikslager AT. (2002) The effects of cyclooxygenase inhibitors on bile-injured and normal equine colon. Equine Vet J 34:493-498.

Gayle J, Jones SL, Argenzio RA, Blikslager AT. (2002) Neutrophils increase paracellular permeability of restituted ischemic injured porcine ileum. Surgery 132:461-470.

Chilcoat CD, Rowlingson KA, Jones SL. (2002) The effects of cAMP modulation upon the adhesion and respiratory burst activity of immune complex-stimulated equine neutrophils. Vet Immunol Immunopathol 88:65-77.

Jones SL. (2002) Protein kinase A regulates beta-2 integrin avidity in neutrophils. J Leukoc Biol 71:1042-1048.

Jones SL, Sharief Y, Chilcoat CD. (2001) Signaling mechanism for equine neutrophil activation by immune complexes. Vet Immunol Immunopath 82:87-100.

Betsuyaku T, Liu F, Senior RM, Haug JS, Brown EJ, Jones SL, Matsushima K, Link DC. (1999) A functional granulocyte colony-stimulating factor is required for normal chemoattractant-induced neutrophil activation. J Clin Invest. 103:825.

Jones SL, Wang J, Turck CW, Brown EJ. (1998) A role for the actin-bundling protein L- plastin in the regulation of leukocyte integrin function. Proc Natl Acad Sci, USA. 95:9331-9336.

Jones SL, Wilson WD. (1998) Effect of intravenous fluid administration on the pharmacokinetics of gentamicin in healthy adult horses. J Vet Pharmacol Ther 21:247-249.

Jones SL, Knaus UG, Bokoch GM, Brown EJ. (1998) Two signaling mechanisms for activation of alphaMbeta2 avidity in polymorphonuclear neutrophils. J Biol Chem 273:10556-10566.

Jones SL, Brown EJ. (1996) FcgammaRII-mediated adhesion and phagocytosis induce L-plastin phosphorylation in human neutrophils. J Biol Chem 271:14623-14630.

Rosales C, Jones SL, McCourt D, Brown EJ. (1994) Bromophenacyl bromide binding to the actin-bundling protein L-plastin inhibits inositol triphosphate-independent increase in Ca2+ in human neutrophils. Proc Natl Acad Sci USA. 91:3534-3538.

Clinical Research and Case Reports

Sheats MK, Cook VL, Jones SL, Blikslager AT, Pease AP. (2009) Use of ultrasound to evaluate outcome following colic surgery for equine large colon volvulus. Equine Vet J (Accepted).

Jones SL, Maggi R, Shuler J, Alward A, Breitschwerdt EB. (2008) Detection of Bartonella henselae in the blood of two adult horses. J Vet Intern Med 22:495–498.

Sheats MK, Van Wetter AJ, Snyder LA, Jones SL. (2008) Disseminated large granular lymphoma in a horse. Equine Vet Educ 20:459-463.

Jones SL, Valenzisi A, Sontakke S, Sprayberry KA, Maggi R, Hegarty B, Breitschwerdt EB.  (2007) Use of an insect cell culture growth medium to isolate bacteria from horses with effusive, fibrinous pericarditis: a preliminary study.  Vet Micro 121:177-181.

Alward AL, Pease AP, Jones SL.  (2007) Thoracic discospondylitis with associated epaxial muscle atrophy in a Quarter Horse gelding.  Equine Vet Educ 19:67-71.

Morton AJ, Davis JL, Redding WR, Jones SL. (2007) Non-Secretory Multiple Myeloma in a Horse.  Equine Vet Educ 19:564-568.

Fogle C, Gerard M, Johannson AM, Breuhaus BA, Blikslager AT, Jones SL. (2007) Spontaneous rupture of the guttural pouch as a complication of treatment for guttural pouch empyema. Equine Vet Educ 19:351-355.

Federico LM, Jones SL, Blikslager AT. (2006) Predisposing factors for small colon impaction in horses and outcome of medical and surgical treatment: 44 cases (1999-2004). J Am Vet Med Assoc 229:1612-1616

Barton MH, Hurley D, Norton N, Heusner G, Costa L, Jones SL, Byars D, Watanabe K. (2006) Serum lactoferrin and immunoglobulin G concentrations in healthy or ill neonatal foals and healthy adult horses. J Vet Intern Med 20:1457-1462.

Alward A, Corriher CA, Barton MH, Sellon DC, Blikslager AT, Jones SL. (2006) Red Maple (Acer rubrum) leaf toxicosis in horses: A retrospective study of 32 cases.  J Vet Intern Med 20:1197-1201.

Zimmerman B, Rotstein D, Jones SL. (2004) Large granular lymphoma in a mule.  Vet Rec 155:462-3.

Davis JL, Jones SL. (2003) Suppurative cholangiohepatitis and enteritis in adult horses. J Vet Intern Med 17:583-587.

Davis JL, Blikslager AT, Catto K, Jones SL.  (2003) A retrospective analysis of hepatic injury in horses with proximal enteritis (1984-2002) J Vet Intern Med 17:896-901.

Jones SL, Davis JL, Rowlingson KA. (2003) Ultrasonographic findings in horses with right dorsal colitis: 5 cases (2000-2001). J Am Vet Med Assoc. 222:1248-1251.

Davis JL, Gilger BC, Spaulding K, Ian D Robertson ID, Jones SL. (2002) Nasal adenocarcinoma with diffuse metastases involving the orbit, cerebrum, and multiple cranial nerves in a horse. J Am Vet Med Assoc 221:1460-1463.

Davis JL, Gardner SY, Jones SL, Schwabenton BA, Papich MG. (2002) Pharmacokinetics of azithromycin in foals after IV and oral dose and disposition into phagocytes. J Vet Pharmacol Ther 25:99-104.

Stanar LS, Little D, Redding, WR, Jones SL. (2002) Idiopathic eosinophilic enteritis in a 10 week old colt. Compend Contin Educ Pract Vet 24:342-344.

Little D, Keene BW, Bruton C, Smith LJ, Powell S, Jones SL. (2001) Percutaneous retrieval of a jugular catheter fragment from the pulmonary artery of a 10-day-old foal. J Am Vet Med Assoc 220:212-214.

Davis JL, Ramirez S, Campbell N, Jones SL. (2001) Acute and chronic mineral oil pneumonitis in two horses. Equine Vet Educ 13:230-234.

Jones SL, Zimmel D, Tate LP, Campbell N, Redding WR, Carlson GP. (2001). Dysphagia caused by squamous cell carcinoma in 2 horses. Compend Contin Educ Pract Vet 23:1020-1024.

Blikslager AT, Tate LP, Jones SL. (2001) Neodymium:yttrium-aluminum-garnet laser ablation of a urethral web to relieve urinary outflow obstruction in a horse. J Am Vet Med Assoc 218:1970-1972.

Zimmel DN, Blikslager AT, Jones SL, McFarlane D, Young K. (2000) Vaccine-associated anaphylactic-like reaction in a horse. Compend Contin Educ Pract Vet 22:81-85.

Byrne E, Cohen N, Jones SL, Zimmel DN, Valberg S. (2000) Rhabdomyolysis in two foals with polysaccharide storage myopathy. Compend Contin Educ Pract Vet 22:503-509.

Little D, Redding WR, Spaulding KA, Dupree SH, Jones SL. (2000) Unusual presentation of nutritional secondary hyperparathyroidism in a Paint colt. Equine Vet Educ 2:388-394.

Perkins G, Valberg SJ, Madigan JM, Carlson GP, Jones SL. (1998) Electrolyte disturbances in foals with severe rhabdomyolysis. J Vet Intern Med 12:173-177.

Jones SL, Fecteau G. (1995) Hydrops uteri in a goat pregnant with goat-sheep hybrid fetuses. J Am Vet Med Assoc 206:1920-2.

Jones SL, Langer DL, Sterner-Kock A, Snyder JR, Carlson GP. (1994) Renal dysplasia and benign ureteropelvic polyps associated with hydronephrosis in a foal. J Am Vet Med Assoc 204:1230-1234.

Jones SL, Wilson WD. (1993) Clostridium septicum septicemia in a neonatal foal with hemorrhagic enteritis. Cornell Vet 83:143-151.

Mattoon JS, Andrews D, Jones SL, Linford RL. (1991) Subepiglottic cyst causing upper airway obstruction in a neonatal calf. J Am Vet Med Assoc 199:747-749.

Invited Chapters and Reviews

Jones SL. (2009) Inflammatory diseases of the gastrointestinal tract causing diarrhea. In: Reed SM, Bayly WM, Sellon DC. (eds). Equine Internal Medicine, 3rd edition.  WB Saunders, Philadelphia, Pa. (In Press).

Jones SL. (2009) Pathophysiology of gastrointestinal inflammation. In: Reed SM, Bayly WM, Sellon DC. (eds). Equine Internal Medicine, 3rd edition.  WB Saunders, Philadelphia, Pa. (In Press).

Jones SL, Pease AP. (2008) Diagnostic procedures in the examination of the equine alimentary system. In: Smith BP (ed) Large Animal Internal Medicine, 4th edition.  Mosby-Elsevier, St Louis, MO.  pp. 667-676.

Blikslager AT, Jones SL. (2008) Disorders of the esophagus. In: Smith BP (ed) Large Animal Internal Medicine, 4th edition.  Mosby-Elsevier, St Louis, MO. pp. 688-695.

Jones SL. (2008) Medical disorders of the large intestine. In: Smith BP (ed) Large Animal Internal Medicine, 4th edition.  Mosby-Elsevier, St Louis, MO. pp. 742-750.

Jones SL. (2008) Non-steroidal anti-inflammatory drug toxicity. In: Smith BP (ed) Large Animal Internal Medicine, 4th edition.  Mosby-Elsevier, St Louis, MO. pp. 754-757.

Jones SL. (2008) Right dorsal ulcerative colitis. In: Robinson NE (ed) Current Therapy in Equine Medicine, 6th edition. Saunders, Philadelphia PA. pp. 430-432.

Jones SL. (2008) Antibiotic associated diarrhea. In: Robinson NE (ed) Current Therapy in Equine Medicine, 6th edition. Saunders, Philadelphia PA. pp. 433-435.

Little D, Jones SL, Blikslager AT.  (2007) The cyclooxygenase (COX) inhibitors: COX-(in)dependent effects and the intestine.  J Vet Intern Med 21:367–377.

Blikslager AT, Moeser AJ, Gookin JL, Jones SL, Odle J.  (2007) Restoration of barrier function in injured intestinal mucosa. Physiol Rev 87:545-64.

Jones SL. Cholangiohepatitis, suppurative cholangitis, and cholelithiasis. (2006). Compend Cont Educ Vet Equine Edition 1:222-225.

Blikslager AT, Jones SL. (2005) NSAIDs. J Equine Vet Sci 25:98-102.

Blikslager AT, Jones SL, Grondahl ML, Merritt AM. (2004) Pathophysiology of the gastrointestinal tract.  In: Dunlop RH, Malbert CH (eds). Veterinary Pathophysiology.  Blackwell Publishing, Ames IA. pp.111-142.

Jones SL. (2003) Treatment of acute and chronic gastrointestinal inflammation. Vet Clin North Am Equine Pract 19:697-714.

Jones SL, Blikslager AT (2002) Role of the enteric nervous system in the pathophysiology of secretory diarrhea. J Vet Intern Med 16:222-228.

Jones SL, Blikslager AT. (2001) Future directions in anti-inflammatory therapy. Vet Clin North Am Equine Pract 17:245-262.

Blikslager A, Jones SL. (2001) Disorders of the Esophagus. In: Smith BP (ed) Large Animal Internal Medicine. Mosby, St Louis, MO. pp 607-617.

Gayle JM, Blikslager AT, Jones SL. (2000) Role of neutrophils in intestinal mucosal injury. J Am Vet Med Assoc 217:498-500.

Jones SL, Lindberg FL, Brown EJ. (1999) Phagocytosis. In: Paul WE (ed). Fundamental Immunology. Raven Press, New York, NY. pp 997-1020

Jones SL, Brown EJ. (1996) Functional cooperation between Fc receptors and complement receptors in phagocytes. In: van de Winkel JGJ, Capel PJA (eds). Human IgG Fc Receptors. RG Landes Co, Georgetown, Texas, pp 149-163.