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B. Duncan X. Lascelles, BSc, BVSc, PhD, CertVA, DSAS(ST), DECVS, DACVS

B. Duncan X. Lascelles

Professor, Small Animal Surgery
Phone: 919.513.6588
Fax: 919.513.6464
Email: duncan_lascelles@ncsu.edu

Education

Doctor of Philosophy (PhD), University of Bristol, United Kingdom
Bachelor of Veterinary Science, University of Bristol, United Kingdom
Bachelor of Science (Zoology), University of Bristol, United Kingdom

After graduating from the veterinary program at the University of Bristol, U.K., in 1991 with honors, Dr. Lascelles completed a PhD in aspects of pre-emptive/perioperative analgesia at the University of Bristol. After an internship there, he completed his surgical residency at the University of Cambridge, U.K., in 1999. He moved to Colorado for the Fellowship in Oncological Surgery at Colorado State University, then a period of research in feline pain and analgesia at the University of Florida, and is currently Assistant Professor in Small Animal Surgery with active clinical and research interests in acute and chronic pain. He organizes the Integrated Pain Management Service. He is board-certified in small animal surgery by the Royal College of Veterinary Surgeons, the European College of Veterinary Surgeons, and the American College of Veterinary Surgeons.

Clinical Specialty

Clinical pain management, General and Orthopedic surgery (especially musculoskeletal oncological surgery, reconstructive surgery, maxillo-facial surgery)

Professional Experience & Qualifications

Diplomate, American College of Veterinary Surgeons
Diploma, Royal College of Veterinary Surgeons Small Animal Surgery (Soft Tissue)
Diplomate, European College of Veterinary Surgeons
Surgical Oncology Fellowship, Colorado State University, United States
Surgical Residency, University of Cambridge, United Kingdom

Research Areas

Clinical measurement of acute and chronic pain
Understanding the basis of pain in animals
Alleviation of pain in animals

Selected Publications

Lascelles BDX, Thomson Sumrell A, Henry III JB, Brown J, Simpson W, Hansen BD, Robertson I, Zamprogno H, Freire M, Pease A. Cross-sectional study evaluating the prevalence of radiographic degenerative joint disease in domesticated cats. Accepted for publication December 2009, Veterinary Surgery July 2009

Zamprogno H, Hansen BD, Bondell HD, Thomson Sumrell A, Simpson W, Robertson I, Brown J, Pease A, Roe SC, Hardie E, Lascelles BDX. Development of a questionnaire to assess degenerative joint disease-associated pain in cats: Item generation and questionnaire format. Accepted for publication, American Journal of Veterinary Research, July 2009 [corresponding author].

Gilor C, Graves TK, Lascelles BDX, Thomson AE, Simpson W, Halpern DS. Sex, body weight and body condition affect serum fructosamine concentrations in non-diabetic cats. Accepted for publication, Veterinary Clinical Pathology June 2009

Trumpatori B, Carter JE, Hash J, Davidson GS, Mathews KG, Roe SC, Lascelles BDX. Evaluation of a mid-humeral block of the radial, ulnar, musculocutaneous and median nerves for analgesia of the distal forelimb in the dog. Accepted for publication, Veterinary Surgery, July 2009.

Wooten J, Lascelles BDX, Cook V, Law M, Blikslager AT. Evaluation of the Relationship between Gastrointestinal Injury and Cyclooxygenase (COX) Expression in Clinically Normal Dogs. Accepted for publication, American Journal of Veterinary Reserach, February 2009

Lascelles BDX, DePuy V, Thomson Summrell A, Hansen B, Marcellin-Little D, Bauer JE. (2010) Pain relieving and activity-enhancing properties of a putative therapeutic diet for feline degenerative joint disease associated pain. Journal of Veterinary Internal Medicine, Mar 22. [Epub ahead of print]

Freire M, Brown J, Robertson I, Pease A, Hash J, Hunter S, Thomson Sumrell A, Simpson W, Lascelles BDX. (2010) Meniscal mineralization in domestic cats. Veterinary Surgery, Mar 19. [Epub ahead of print]

Lascelles BDX, Friere M, DePuy V, Roe S, Smith E, Marcellin-Little D. (2010) Evaluation of functional outcome following BFX total hip replacement system using a pressure sensitive walkway. Veterinary Surgery 39: 71-77

Lascelles BDX, King S, Roe S, Marcellin-Little DJ, Jones S. (2009) Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis. Journal of Orthopedic Research 27: 1204-1208 [March 2009, 10.1002/jor.20864, Epub ahead of print]

Wooten J, Blikslager AT, Marks S, Law M, Graeber E, Lascelles BDX. (2009) Effect of non-steroidal anti-inflammatory drugs with varying cyclooxygenase (COX)-2 selectivity on COX protein and prostanoid concentrations in canine pyloric and duodenal mucosa. American Journal of Veterinary Research 70:1243-1249.

Robertson SA, Wegner K, Lascelles BDX. (2009) Antinociceptive and side-effects of hydromorphone after subcutaneous administration in cats. Journal of Feline Medicine and Surgery 11:76-81 [Jul 31: http://dx.doi.org/10.1016/j.jfms.2008.05.003. Epub ahead of print]

Benito-de-la-Víbora J, Lascelles BDX, García-Fernández P, Friere M, Gómez de Segura IA. (2008) Efficacy of tolfenamic acid and meloxicam in the control of postoperative pain following ovariohysterectomy in the cat. Veterinary Anaesthesia and Analgesia 35:501-510 [ June 19 2008, Epub ahead of print]

Vince KJ, Lascelles BDX, Mathews KG, , Altier C, Roe SC. (2008) Evaluation of distal leg wraps for the prevention of bacterial strike-through in an ex vivo canine model. Veterinary Surgery 37: 406-411

Wooten JG, Blikslager AT, Ryan KA, Marks SL, Law M, Lascelles BDX. (2008) Cyclooxygenase expression and prostanoid production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal anti-inflammatory drugs. American Journal of Veterinary Research 69 (4): 457-464

Lascelles BDX, Gaynor J, Smith ES, Roe SC, Marcellin-Little DJ, Davidson G, Carr J. (2008) Evaluation of amantadine as part of a multimodal analgesic regimen for the alleviation of refractory osteoarthritis pain. Journal of Veterinary Internal Medicine 22(1): 53-59

Reid J, Nolan AM, Hughes JML, Lascelles BDX, Pawson P, Scott EM. (2007) Development of the short-form Glasgow Composite Measure Pain Scale (CMPS-SF) and derivation of an analgesic intervention score. Animal Welfare 16(S): 97-104

Lascelles BDX, Hansen BD, Thomson A, Pierce CC, Rowinski E, Smith ES. (2008) Evaluation of a digitally integrated accelerometer-based activity monitor for the measurement of activity. Veterinary Anaesthesia and Analgesia 35(2):173-183. Epub 2007 Oct 10.

Jaeger GH, Marcellin-Little DJ, DePuy V, Lascelles BDX. (2007) Validity of, Goniometric Measurements in Cats. American Journal of Veterinary Research 68:822-826.

Lascelles BDX , Hansen BD, Roe S, DePuy V, Thomson A, Pierce CC, Smith ES, Rowinski E. (2007) Evaluation of client specific outcome measures and activity monitoring to measure pain relief in cats with osteoarthritis. Journal of Veterinary Internal Medicine 21(3):410-416

Hansen B, Lascelles BDX, Keene BW, Adams A, Thomson A. (2007) Evaluation of an accelerometer for at-home monitoring of spontaneous activity in dogs. American Journal of Veterinary Research 68(5):468-475

Lascelles BDX, Findley K, Correa M, Roe S. (2007) Kinetic evaluation in normal cats using a pressure sensing walkway. Veterinary Record 160(15):512-516

Thomas TM, Marcellin-Little DJ, Roe SC, Lascelles BDX, Brosey BP. Comparison of measurements obtained by use of an electrogoniometer and a universal plastic goniometer for the assessment of joint motion in dogs. American Journal of Veterinary Research 67(12):1974-9.

Lascelles BDX, Roe SC, Smith E, Reynolds BS, Markham J, Bergh MS, Marcellin D, Budsberg SC. (2006) Evaluation of a pressure walkway system for measurement of vertical limb forces in clinically normal dogs. American Journal of Veterinary Research 67(2):277-82.

Morrow WE, Meyer RE, Roberts J and Lascelles BDX. (2006) Financial and welfare implications of immediate euthanasia of casualty nursery pigs. Journal of Swine Health Production 14(1):25-34.

Lascelles BDX, Dernell W, Correa MT, Lafferty M, Devitt C, Kuntz C, Straw R and Withrow S. (2005) Improved Survival Associated with Postoperative Wound Infection in Dogs Treated with Limb-salvage Surgery for Osteosarcoma. Annals of Surgical Oncology 12:1-11.

KuKanich B, Lascelles BDX, Aman A, Mealey AL and Papich MG. (2005) Use of a von Frey device for evaluation of pharmacokinetics and pharmacodynamics of morphine after intravenous administration as an infusion or multiple doses in dogs. American Journal of Veterinary Research 66:1968-1974.

Robertson SA, Lascelles BDX, Taylor PM and Sear JW. (2005) PK-PD modeling of buprenorphine in cats: intravenous and oral transmucosal administration. Journal of Veterinary Pharmacology and Therapeutics 28:453-460.

Lascelles BDX, Blikslager A, Fox S and Reece D. (2005) Evaluation of 29 cases of duodenal perforation in dogs receiving a selective COX-2 inhibitor. Journal of American Veterinary Medical Association 227:1112-1117.

Kukanich B, Lascelles BDX, Papich M. (2005) Pharmacokinetics and Pharmacodynamics of Morphine in Dogs following Intravenous Infusion and Multiple Intravenous Doses. American Journal of Veterinary Research 28:371-376.

KuKanich B, Lascelles BDX and Papich MG. (2005) Evaluation of a von Frey Device for Pharmacodynamic Modeling of Morphine in Dogs. American Journal of Veterinary Research 66: 1616-1622.

Kukanich B, Lascelles BDX and Papich M. (2005) Pharmacokinetics of morphine and plasma concentrations of morphine-6-glucuronide following morphine administration to dogs. Journal of Veterinary Pharmacology and Therapeutics 28: 371-376.

Jaeger GH, Wosar MA, Marcellin-Little DJ and Lascelles BDX.(2005) Hinged Transarticular External Fixation for Joint Stabilization in Dogs. Journal of the American Veterinary Medical Association 227:586-91.

Williams VM, Lascelles BDX and Robson MC. (2005) Current attitudes to, and use of, perioperative analgesia in dogs and cats by New Zealand veterinarians. New Zealand Veterinary Journal 53(3), 193-202.

Kukanich B, Lascelles BDX and Papich M. (2005) Validation of a high pressure liquid chromatography and florescence polarization immunoassay for the determination of methadone in canine plasma. Therapeutic Drug Monitoring 27: 389-392.

Liptak JM, Dernell WS, Lascelles BDX, LaRue SM, Jameson V, Powers BE and Huber DJ, Withrow S. (2004) Intraoperative Extracorporeal Irradiation for Limb-Sparing in 13 Dogs. Veterinary Surgery 33:446-456.

Lascelles BDX and Robertson SA. (2004) Use of thermal threshold response to evaluate the antinociceptive effects butorphanol in cats. American Journal of Veterinary Research 65(8):1085-1089.

Lascelles BDX and Robertson SA. (2004) Antinociceptive effects of hydromorphone, butorphanol, or the combination in cats. Journal of Veterinary Internal Medicine 18: 190-195.

Lascelles BDX, Henderson RA, Liptak J, Seguin B and Withrow SJ. (2004) Bilateral rostral maxillectomy and nasal planectomy for large rostral maxillofacial neoplasms in six dogs and one cat. Journal of the American Animal Hospital Association 30: 137-146.

Lascelles BDX, Thompson MJ, Dernell WS, Straw RC and Withrow SJ. (2003) Combined dorsolateral and intraoral approach for the resection of tumors of the maxilla in the dog. Journal of the American Animal Hospital Association 39: 294-305.

Robertson SA, Taylor PM, Lascelles BDX and Dixon MJ. (2003) Changes in thermal threshold response in eight cats after administration of buprenorphine, butorphanol and morphine. Veterinary Record 153: 462-465.

Taylor P, Robertson SA, Dixon MJ, Ruprah M, Sear JW, Lascelles BDX, Waters C and Bloomfield M. (2001) Morphine, pethidine and buprenorphine disposition in the cat. Journal of Veterinary Pharmacology and Therapeutics 24: 391-398.

Lascelles BDX, Henderson AJ and Hackett IJ. (2001) Evaluation of the clinical efficacy of meloxicam in cats with locomotor disorders. Journal of Small Animal Practice 42: 587-593.

Lascelles BDX and White RAS. (2001) Combined omental pedicle grafts and thoracodorsal axial pattern flaps for the reconstruction of chronic, non-healing axillary wounds in cats. Veterinary Surgery 30: 380-385.

Lascelles BDX, Parry A, Stidworthy MF, Dobson JM and White RAS. (2000) Squamous Cell Carcinoma of the Canine Nasal Plate in 17 dogs. Veterinary Record 147: 473-476.

Lascelles BDX, Capner CA and Waterman-Pearson AE. (1999) Current British Veterinary attitudes to peri-operative analgesia for cats and small mammals. Veterinary Record 145: 601-604.

Capner CA, Lascelles BDX and Waterman-Pearson AE. (1999) Current British Veterinary attitudes to perioperative analgesia for dogs. Veterinary Record 145: 95-99.

Lascelles BDX, Cripps PJ, Jones A and Waterman-Pearson AE. (1998) Efficacy and kinetics of carprofen, administered preoperatively or postoperatively, for the prevention of pain in dogs undergoing ovariohysterectomy. Veterinary Surgery 27: 568-582.

Lascelles BDX, Davison L, Dunning M, Bray JP and White RAS. (1998) The use of omental pedicle grafts in reconstruction of non-healing axillary wounds in 10 cats. Journal of Small Animal Practice 39: 475–480.

Bray JP, White RAS and Lascelles BDX. (1998) Treatment of canine nasal aspergillosis with a new non-invasive technique; Part one: Failure with enilconazole. Journal of Small Animal Practice 39: 223–226.

Lascelles BDX, Cripps PJ, Jones A and Waterman-Pearson AE. (1997) Post-operative central hypersensitivity and pain: the pre-emptive value of pethidine for ovariohysterectomy. Pain 73: 461–471.

Lascelles BDX, Cripps PJ, Mirchandani S and Waterman AE. (1995) Carprofen as an analgesic for postoperative pain in cats: Dose titration and assessment of efficacy in comparison to pethidine hydrochloride. Journal of Small Animal Practice 36: 535-541.

Lascelles BDX, Waterman AE, Cripps PJ, Livingston A and Henderson G. (1995) Central sensitisation as a result of surgical pain - investigation of the pre-emptive value of pethidine for ovariohysterectomy in the rat. Pain 62: 201-212.

Lascelles BDX, Butterworth SJ and Waterman AE. (1994) Postoperative analgesic and sedative effects of carprofen and pethidine in dogs. Veterinary Record 134: 187-191.

Case Reports in Peer-Reviewed Journals

Mathews KG, Riley K, Lascelles BDX, Dernell WS. (2010) Preparation of Canine and Feline Cadavers for Surgical Laboratories. Veterinary Surgery 39: 224-225. [Epub: 6th January 2010, DOI: 10.1111/j.1532-950X.2009.00586.x]

Langley-Hobbs SJ and Lascelles BDX. (2004) Phalangeal fractures and metacarpophalangeal luxations subsequent to post-traumatic osteomyelitis and cellulitis in a dog. Journal of Small Animal Practice 45(7):368-71.

Lascelles BDX, Monnet E, Liptak J, Johnson J and Dernell W. (2003) Surgical treatment of right-sided renal lymphoma with invasion of the caudal vena cava. Journal of Small Animal Practice 44: 135-13.

Innes JF, McKee WM, Mitchell RAS, Lascelles BDX, Johnson KA. (2001) Surgical reconstruction of ectrodactyly deformity in four dogs. Veterinary Comparative Orthopaedics and Traumatology 14: 201-209.

Lascelles BDX, McInnes E, Dobson J and White RAS. (1998) Rhabdomyosarcoma of the tongue of a dog. Journal of Small Animal Practice 39: 587–591.

Review Articles in Peer-Reviewed Journals

Lascelles BDX & Robertson SA. (2010) Diagnosing and treating degenerative joint disease associated pain. (Invited Review) Journal of Feline Medicine and Surgery 12:200-212.

Robertson SA & Lascelles BDX. (2010) Long term pain in cats – conditions, diagnosis and management. (Invited Review) Journal of Feline Medicine and Surgery 12:188-199.

Lascelles BDX. (2010) ‘Post-operative analgesia in the dog: a comparison of morphine, buprenorphine and pentazocine’ Invited Commentary, 50th Issue of Journal of Small Animal Practice, Journal of Small Animal Practice 51 (supplement 1): 46-48.

Innes JF, Clayton J, Lascelles BDX. (2010) Systematic review of the safety and efficacy of long-term NSAID use in the treatment of canine osteoarthritis. Veterinary Record 166: 226-230.

Lascelles BDX. (2010) Feline Degenerative Joint Disease. (Invited Review) Veterinary Surgery 39: 2-13
Davis KM, Hardie EM, Lascelles BDX, Hansen B (2007) Feline fibrosarcoma: Perioperative management. Compendium of Continuing Education, December 2007: 712-732.

Lascelles BDX, Court MH, Hardie EM, Robertson SA (2007) Nonsteroidal anti-inflammatory drugs in cats: a review. Veterinary Anaesthesia and Analgesia 34(4): 228-250. Epub 2007 Apr 23. Review.

Lascelles BDX, McFarland JM, Swann H. (2005) Guidelines for Safe and Effective Use of NSAIDs in Dogs. Veterinary Therapeutics 6(3):237-51.

Epstein M, Kuehn NF, Landsberg G, Lascelles BDX, Marks SL, Schaedler JM and Tuzio H. (2005) AAHA Senior Care Guidelines for Dogs and Cats (Review). Journal of the American Animal Hospital Association 41: 81-91.

Lascelles BDX. (2002) Drug therapy for acute and chronic pain in the cat. International Journal of Pharmaceutical Compounding 6:338-343.

Lascelles BDX and Main DJ. (2002) Surgical trauma and chronically painful conditions – within our comfort level but beyond theirs? Journal of the American Animal Hospital Association 221: 215-221.

Shafford HL, Lascelles BDX and Hellyer PW. (2001) Preemptive analgesia: managing pain before it begins. Veterinary Medicine June 2001: 478-492.

Lascelles BDX. (2000) Preemptive analgesia: an aid to postoperative pain control. Journal of Pain 1: 93-95.

Commissioned Articles, Book Chapters, Books and Bulletins

Dunning D and Lascelles BDX (2007) Rehabilitation and Palliative Analgesia. In: Lumb & Jones Veterinary Anesthesia and Analgesia, Eds Tranquilli WJ, Thurmon JC and Grimm KA, 4th Edition, Blackwell Publishing, Ames, Iowa, pp 697-704.

Lascelles BDX and Gaynor JS (2007) Anesthesia and Analgesia for Selected Patients and Procedures: Caner Patients. In: Lumb & Jones Veterinary Anesthesia and Analgesia, Eds Tranquilli WJ, Thurmon JC and Grimm KA, 4th Edition, Blackwell Publishing, Ames, Iowa, pp 997-1008.

Lascelles BDX (2006) Management of chronic cancer pain. In: Small Animal Clinical Oncology, Eds: Withrow S and McEwan, Saunders Elsevier, St. Louis, Missouri, USA, pp 291-306.

Lascelles BDX (2006). Tumours of the musculoskeletal system: primary appendicular bone tumours and appendicular joint tumours. In: BSAVA Manual of Lameness, Eds: Houlton JEF, BSAVA Publications, Cheltenham, UK

Dobson J and Lascelles BDX (2003 – translated 2005) Co-editor of British Small Animal Veterinary Association Manual of Oncology, (Japenese Translation), 2nd Edition, BSAVA Publications, Cheltenham, UK, pp 344.

Lascelles BDX, McFarland JM (November 2004) Guidelines for safe and effective use of non-steroidal anti-inflammatory drugs in dogs, Pfizer Animal Health Technical Bulletin.

Lascelles BDX (2004) Current Viewpoints and Guidelines on Safe and Effective Use of Non-Steroidal Anti-Inflammatory Drugs in Companion Animals, white paper commissioned by Pfizer Animal Health.

Lascelles BDX (2004) Perspectivas futures en el manejo del dolor, In: Dolor Evaluacion y Tratamiento en Pequenos Animales (Pain Evaluation and Treatment in Small Animals), Ed: Otero PE, Inter-Medica, Buenos Aires, Republica Argentina, pages 239-243.

Lascelles BDX (2004) Manejo del dolor cronico en pequenos animals: tratamiento multimodal, In: Dolor Evaluacion y Tratamiento en Pequenos Animales (Pain Evaluation and Treatment in Small Animals), Ed: Otero PE, Inter-Medica, Buenos Aires, Republica Argentina, pages 137-149.

White RN and Lascelles BDX (2003) Tumours of the Respiratory System and Thoracic Cavity, In: BSAVA Manual of Oncology, Eds: Dobson J and Lascelles BDX, 2nd Edition, BSAVA Publications, Cheltenham, UK, pages 259-275.

Lascelles BDX (2003) Relief of Chronic Cancer Pain, In: BSAVA Manual of Oncology, Eds: Dobson J and Lascelles BDX, 2nd Edition, BSAVA Publications, Cheltenham, UK, pages 137-151.

Lascelles BDX (2003) Principles of Oncological Surgery, In: BSAVA Manual of Oncology, Eds: Dobson J and Lascelles BDX, 2nd Edition, BSAVA Publications, Cheltenham, UK, pages 73-85.

Dobson J and Lascelles BDX (2003) Co-editor of British Small Animal Veterinary Association Manual of Oncology, 2nd Edition, BSAVA Publications, Cheltenham, UK, pp 344.

Lascelles BDX (2001) contributor to ‘The Veterinary Formulary’, chapter on ‘Drugs used in the treatment of the musculoskeletal system and joints’, editor Y Bishop, 5th Edition, Pharmaceutical Press, London, pages 469-488.

Lascelles BDX (2000) Contributor to ‘Pain management in animals’, chapters on ‘Pain recognition and pain assessment’ and ‘Management of post-operative and other acute pain’, editors P Flecknell and AE Waterman-Pearson, WB Saunders, London, UK, pages 53-80, 81-146.

Lascelles BDX (2000) Practical peri-operative analgesia - the present and the future Walthum Focus, January 2000.

Lascelles BDX and White RAS (1999) Principles of Oncological Surgery, In Practice, April 1999.

Lascelles BDX (1997) Analgesia in cats, In Practice, April 1997.

Lascelles BDX (1996) ‘The Veterinary Annual’, chapter on ‘Recent advances in the control of pain in animals’, editors Raw, M-E and Parkinson, T, Blackwells Science Publications, Bristol, pages 1-19.

Links

Integrated Pain Management Service

Comparative Pain Research Laboratory

Special Interest Group of the International Association for the Study of Pain (IASP) on Pain and Pain Management in Non-Human Species