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Denis Marcellin-Little, DEDV

Denis Marcellin-Little

Professor, Orthopedics
Phone: 919.513.6284
Fax: 919.513.6464


Dr. Marcellin-Little is a French-born veterinarian who graduated from the veterinary college of Toulouse in 1988. Dr. Marcellin-Little is a Diplomate of the American and European Colleges of Veterinary Surgeons, a Diplomate of the American College of Veterinary Sports Medicine and Rehabilitation, and a Professor of orthopedic surgery.


Total hip replacement, external fixation, treatment of bone deformities, physical therapy.

Professional Experience & Qualifications

Dr. Marcellin-Little has specific knowledge of animal physical therapy and rehabilitation. He is an adjunct clinical faculty member of the Department of Physical Therapy at the University of Tennessee, Chattanooga, and is actively involved in teaching and investigating this emerging field. Dr. Marcellin-Little chaired the International Symposium on Animal Physical Therapy and Rehabilitation in August 2004. He is a charter Diplomate of the American College of Veterinary Sports Medicine and Rehabilitation.

Research Area

Biological response to orthopedic implants; Distraction osteogenesis; Canine developmental orthopedic diseases.

Selected Publications

Dr. Marcellin-Little has written approximately 100 articles – half of these are peer-reviewed research projects in the fields of joint arthroplasty, (circular) external fixation, biomodeling, and biomanufacturing.

Recent Original Research Studies - In press

Apelt D, Pozzi A, Marcellin-Little DJ, Kowaleski MP. Effect of cranial tibial closing wedge angle on tibial subluxation: an ex vivo study. Vet Surg, in press (accepted 12/09)

Lascelles BDX, DePuy V, Thomson A, Hansen B, Marcellin-Little DJ, Biourge V, Bauer JE. Evaluation of a therapeutic diet for feline degenerative joint disease. J Vet Intern Med, in press (accepted 12/09).

Marcellin-Little DJ, Sutherland B, Harrysson OLA, Lee ES. In vitro evaluation of free-form biodegradable bone plates for fixation of a distal femoral physeal fracture. Am J Vet Res, in press (accepted 11/09).

Levine D, Marcellin-Little DJ, Millis DL, Tragauer V, Osborne JA. Effects of immersion on weight-bearing and weight distribution in dogs. Am J Vet Res, in press (accepted 11/09).

Marcellin-Little DJ, Cansizoglu O, Harrysson OLA, Roe SC. In vitro testing of a low modulus mesh canine prosthetic hip stem. Am J Vet Res, in press (accepted 09/09)

Chanoit G, Singhani NN, Marcellin-Little DJ, Osborne JA. Radiographic assessment of the medial aspect of the humeral condyle in dogs with osteochondritis dissecans. Am J Vet Res, in press (accepted 09/09).

Original Research Studies - Published in the last 3 years

Lascelles BDX, Freire M, Roe SC, DePuy V, Smith E, Marcellin-Little DJ. Evaluation of Functional outcome after BFX total hip replacement using a pressure sensitive walkway. Vet Surg, 2010;39: 71-77

Langenbach A, Marcellin-Little DJ. Management of concurrent patellar luxation and cranial cruciate ligament rupture using modified tibial plateau leveling. J Sm Anim Pract, 2010;51: 97-103

Liska, WD, Doyle N, Marcellin-Little DJ, Osborne JA. Total hip replacement in three cats: surgical technique, short-term outcome and comparison to femoral head ostectomy. Vet Comp Orthop Traumatol 2009;22: 505-510

Lascelles BDX, King S, Roe S, Marcellin-Little DJ, Jones S. Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis. J Orthop Res 2009;27: 1204-1208

Sawaya S, Combet D, Chanoit G, Thiebault J, Levine D, Marcellin-Little DJ. Assessment of impulse duration thresholds for electrical muscle stimulation (chronaxy) in dogs. Am J Vet Res, 2008, 99; 1305-1309

Marcellin-Little DJ, Harrysson OLA, Cansizoglu O. In vitro evaluation of a custom jig and custom plate for canine tibial plateau leveling. Am J Vet Res 2008, 69:961-966

Harrysson OLA, Cansizoglu O, Marcellin-Little DJ, Cormier DR, West HA, II. Direct metal fabrication of titanium implant components with tailored materials and mechanical properties using electron beam melting technology. Mat Sci Eng C, 2008, 28: 366-373

Lascelles BDX, Gaynor J, Smith ES, Roe SC, Marcellin-Little DJ, Davidson G, Carr J. Amantadine in a multimodal analgesic regiment for alleviation of refractory osteoarthritis pain in dogs. J Vet Intern Med 2008, 22: 53-59.

Jaeger GH, Marcellin-Little DJ, Ferretti A. Morphology and correction of distal tibial valgus deformities. J Sm Anim Pract. 2007; 48:678-682

Jaeger GH, Marcellin-Little DJ, Lascelles BDX, Dhupa S. Reliability of goniometry in cats. Am J Vet Res 2007;68: 822-826

Liska WD, Marcellin-Little DJ, Eskelinen EV, Sidebotham CG, Harrysson OLA, Hielm-Björkman AK. Custom Total Knee Replacement in a Dog with Femoral Condylar Bone Loss. Vet Surg 2007;36: 293-301

Lascelles BDX, Findley K, Correa M, Marcellin-Little DJ, Roe SC. Kinetic evaluation in normal walking and jumping cats using a pressure sensing walkway. Vet Rec 2007;160(15): 512-516

Levine D, Colston M, Whittle M, Pharo E, Marcellin-Little DJ. Sagittal lumbar spine position during standing, walking and running. Journal of Athletic Training 2007;42:29-34

Guénégo L, Zahra A, Madelénat A, Gautier R, Marcellin-Little DJ, Hulse D. Cranial cruciate ligament rupture in large and giant dogs. A retrospective evaluation of a modified lateral extracapsular stabilization. Vet Comp Orthop Traumatol 2007;20:43-50

Rovesti GL, Bosio A, Marcellin-Little DJ. Management of 49 antebrachial and crural fractures in dogs using circular external fixators. J Sm Anim Pract 2007;48:194-200

Feeney LC, Lin CF, Marcellin-Little DJ, Tate AR, Queen RM, Yu B. Validation of two-dimensional kinematic analysis of walk and sit-to-stand motions in dogs. Am J Vet Res. 2007;68:277-82

Other Significant Research Studies

Harrysson OLA, Cormier DR, Marcellin-Little DJ, Jajal K. Rapid prototyping for treatment of canine limb deformities. Rapid Prototyping Journal 2003, 9- 37-42

Physical Rehabilitation
Jaeger GH, Wosar MA, Marcellin-Little DJ, Lascelles BDX. Use of hinged transarticular external fixation for adjunctive joint stabilization in dogs and cats: 14 cases (1999-2003). J Am Vet Med Assoc 2005;227, 586-591

Boyle KL, Marcellin-Little DJ, Levine D. An interdisciplinary animal physical rehabilitation course for physical therapy and veterinary students. J Vet Med Educ 2002; 29, 183-185

Jaegger G, Marcellin-Little DJ, Levine D. Reliability of goniometry in Labrador Retrievers, Am J Vet Res 2002;63,979-986

Circular External Fixation
Anderson GM, Lewis DD, Radasch RM, Marcellin-Little DJ, Tommasini-Degna M, Cross AR. Circular external skeletal fixation stabilization of antebrachial and crural fractures in 25 dogs. J Am Anim Hosp Assoc 2002, 39:479-498

Wosar M, Marcellin-Little DJ, Roe SC. Effects of tensioner, bolt torque, wire size, and component wear on wire tension for small- scale circular external fixation systems Veterinary Surgery 2002;31:571-576

Marcellin-Little DJ. Fracture treatment with circular external fixation. Vet Clinics North Am 1999; 29:5, 1153-1170.

Marcellin-Little DJ, Ferretti A, Roe SC, DeYoung DJ. Hinged Ilizarov external fixation for correction of antebrachial deformities. Veterinary Surgery 1998; 27:231-245.

Hip Joint (total hip arthroplasty)
Sebestyen P, Marcellin-Little DJ, DeYoung BA. Medullary infarction secondary to canine total hip arthroplasty. Veterinary Surgery 2000; 29, 227-236.

Marcellin-Little DJ, DeYoung BA, Doyens DH, DeYoung DJ. Uncemented porous-coated anatomic total hip arthroplasty: results of a long-term prospective evaluation of 50 consecutive cases. Veterinary Surgery 1999; 28, 10-20.

Marcellin-Little DJ, Papich MG, Richardson DC, De Young DJ. A model for pharmacokinetic distribution of cefazolin during total hip replacement. Am J Vet Res 1996, 57, 720-723.

Stifle Joint
Hildreth EA, Marcellin-Little DJ, Roe SC, Harrysson OLA. In vitro evaluation of five canine tibial plateau leveling methods. Am J Vet Res 2006; 67,693-700

Osmond CS. Marcellin-Little DJ, Harrysson OLA, Kidd LB. Morphometric assessment of the proximal portion of the tibia in dogs with and without cranial cruciate ligament rupture, Vet Radiol Ultrasound 2006; 47, 136-141

Baroni E, Matthias RR, Marcellin-Little DJ, Vezzoni A, Stebbins ME. Comparisons of radiographic assessments of tibial plateau slope in dogs. Am J Vet Res 2003;64, 586-589

Marcellin-Little DJ, Roe SC, Rovesti GL, Bosio A, Ferretti A. Are circular external fixators weakened by the use of hemispheric washers? Veterinary Surgery 2002, 31, 367-374

Elbow Joint
Haudiquet P, Marcellin-Little DJ, Stebbins ME. Use of the distomedial to lateroproximal oblique radiographic view of the elbow joint for examination of the medical coronoid process in dogs. Am J Vet Res 2002;63:1000-1005

Marcellin-Little DJ, DeYoung DJ, Ferris KK, Berry CM. Incomplete ossification of the humeral condyle in spaniels. Veterinary Surgery 1994; 23: 475-487.