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Lauren V. Schnabel, DVM, PhD, Dip. ACVS, Dip. ACVSMR

Lauren V. Schnabel

Assistant Professor, Equine Orthopedic Surgery
Phone: 919.515.7410
Fax: 919.515.3044
Email: lauren_schnabel@ncsu.edu

Education

Specialty

Professional Experience & Qualifications

Honors

Research Area

Regenerative therapies for the treatment of equine musculoskeletal disorders. In particular, my laboratory is focused on understanding the immunologic and immunomodulatory properties of both mesenchymal and induced pluripotent stem cells. Such knowledge is critical for potential allogeneic “off the shelf” stem cell therapy which would allow us to treat our patients at the time of diagnosis rather than having to wait several weeks to months to culture stem cells from that patient.

Selected Publications

Pezzanite LM, Fortier LA, Antczak DF, Cassano JM, Brosnahan MM, Miller D, Schnabel LV. Equine allogeneic mesenchymal stromal cells elicit antibody responses in vivo. Stem Cell Res Ther 2015; in press.

Cassano JM, Schnabel LV, Betancourt A, Fortier LA. Mesenchymal stem cells - have we delivered on the promise? Curr Pathobiol Rep 2015; in press. Invited Review.

Lustgarten M, Redding WR, Schnabel LV, Prange T, Seiler GS. Navigational ultrasound imaging: A valuable new tool for improving the accuracy of interventional therapy in the treatment of equine musculoskeletal injuries. Equine Vet J 2014; in press.

Radcliffe RM, Manchester A, Mohammed HO, Ortved KF, Reesink HL, Schnabel LV, Lang HM, Scrivani PV, Fubini SL. Laparoscopic-guided compared to skilled instructor support for student rectal examination training using live horses in the veterinary curriculum. Vet Surg 2014; in press.

Schnabel LV, Abratte CM, Schimenti JC, Felippe MJB, Cassano JM, Southard TL, Cross JA, Fortier LA. Induced pluripotent stem cells (iPSCs) have similar immunogenic and more potent immunomodulatory properties compared to bone marrow-derived stromal cells in vitro. Regen Med 2014; 9(5):621-635.

Schnabel LV, Pezzanite LM, Antczak DF, Felippe MJB, Fortier LA. Equine bone marrow-derived mesenchymal stromal cells are heterogeneous in MHC class II expression and capable of inciting an immune response in vitro. Stem Cell Res Ther 2014; Jan 24;5(1):13.

Maher MC, Schnabel LV, Cross JA, Papich MG, Divers TJ, Fortier LA. Plasma and synovial fluid concentration of doxycycline following low-dose, low-frequency administration and resultant MMP-13 inhibition from interleukin-stimulated equine synoviocytes. Equine Vet J 2014; 46(2):198-202.

Boswell SG, Schnabel LV, Sundman EA, Minas T, Fortier LA. Increasing platelet concentration in leukocyte-reduced platelet rich plasma decreases collagen gene synthesis in tendons. Am J Sports Med 2014; 42(1): 42-49.

Schnabel LV, Fortier LA, McIlwraith CW, Nobert KM. Therapeutic use of stem cells in horses: which type, how, and when? Vet J 2013; 197(3): 570-577. Invited Review.

Schnabel LV, Maza PS, Williams KM, Irby NL, McDaniel CM, Collins BG. Use of a formal assessment instrument for the evaluation of veterinary student surgical skills. Vet Surg 2013; 2(4): 488-496.

Ross KA, Williams RM, Schnabel LV, Mohammed HO, Potter HG, Bradica G, Castiglione E, Pownder SL, Satchell PW, Saska R, Fortier LA. Comparison of three methods to quantify repair cartilage collagen orientation. Cartilage 2013; 4(2): 111-120.

Schnabel LV, Abratte CM, Schimenti JC, Southard TL, Fortier LA. Genetic background affects induced pluripotent stem cell (iPSC) generation. Stem Cell Res Ther 2012; 3(4):30.

Schnabel LV, Papich MG, Divers TJ, Altier C, Aprea MS, McCarrel TM, Fortier LA. Pharmacokinetics and distribution of minocycline in adult horses after oral administration of multiple doses and comparison to minimum inhibitory concentrations. Equine Vet J 2012;44(4):453-8.

Nixon AJ, Watts AE, Schnabel LV. Cell and gene based approaches in tendon regenerative medicine. J Shoulder Elbow Surg 2012;21(2):278-294. Invited Review.

Kamm JL, Bramlage LR, Schnabel LV, Ruggles AJ, Embertson RM, Hopper SA. Size and geometry of apical sesamoid fracture fragments as a determinant of prognosis in Thoroughbred racehorses. Equine Vet J 2011; 43(4):412-417.

Schnabel LV, Papich MG, Watts AE, Fortier LA. Orally administered doxycycline accumulates in synovial fluid compared to plasma. Equine Vet J 2010; 42(3):208-212.

Fortier LA, Potter HG, Rickey LJ, Schnabel LV, Ellsworth JR, Foo LF, Chong LR, Stokol T, Nixon AJ, Cheetham JC. Concentrated bone marrow aspirate improves full-thickness cartilage repair compared to microfracture in an equine model of extensive cartilage loss. J Bone Joint Surg Am 2010; 92(10):1927-1937.

Sharma A, Thompson MS, Schnabel LV, Mete A, Hackett R. Imaging diagnosis-equine nasal septal thickening due to chronic chondritis. Vet Radiol Ultrasound 2010; 51(1): 65-68.

Schnabel LV, Lynch ME, van der Meulen MCH, Yeager AE, Kornatowski MA, Nixon AJ. Mesenchymal stem cells and insulin-like growth factor-I gene enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons. J Orthop Res 2009; 27(10):1392-1398.

Furman S, Fortier LA, Schnabel LV, Krotscheck U. Trochlear block recession in an alpaca with traumatic lateral patellar luxation. Vet Surg 2009; 38(3):421-425.

Schnabel LV, Mohammed HO, Jacobson MS, Fortier LA. Effects of platelet rich plasma and acellular bone marrow on gene expression patterns and DNA content of equine suspensory ligament explant cultures. Equine Vet J 2008; 40(3):260-265.

Nixon AJ, Goodrich LR, Scimeca MS, Witte TH, Schnabel LV, Watts AE, Robbins PD. Gene Therapy in Musculoskeletal Repair. Ann NY Acad Sci. 2007; 1117:310-327. Invited Review.

Schnabel LV, Mohammed HO, Miller BJ, McDermott WG, Jacobson MS, Santangelo, KS, Fortier LA. Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons. J Orthop Res 2007; 25(2):230-240.

Schnabel LV, Bramlage LR, Mohammed HO, Embertson RM, Ruggles AJ, Hopper SA. Racing performance after arthroscopic removal of apical sesamoid fracture fragments in immature Thoroughbred horses, < 2 years old: 151 cases (1989-2002). Equine Vet J 2007; 39(1):64-68.

Fortier LA, Schnabel LV, Mohammed HO, Mayr KG. Assessment of cartilage degradation effects of matrix metalloproteinase-13 in equine cartilage co-cultured with synoviocytes. Am J Vet Res 2007; 68(4):379-384.

Schnabel LV, Bramlage LR, Mohammed HO, Embertson RM, Ruggles AJ, Hopper SA. Racing performance after arthroscopic removal of apical sesamoid fracture fragments in Thoroughbred horses ages 2 years and older: 84 cases (1989-2002). Equine Vet J 2006; 38(5):446-451.

Schnabel LV, Njaa BL, Gold JR, Meseck EK. Primary alimentary lymphoma with metastasis to the liver causing encephalopathy in a horse. J Vet Intern Med 2006; 20:204-206.