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Contact Information.

Natasha Olby Vet MB,PhD, MRCVS, DACVIM (Neurology)
Phone: 919-513-8286
Email: natasha_olby@ncsu.edu

Kim Williams
Spinal Cord Injury Program Coordinator
Phone: 919-513-7235
Email: kimberly_williams@ncsu.edu

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Clinical Trials

Now Recruiting

A Phase 1 clinical trial of GGF2 in dogs with disc-induced acute spinal cord injuries
Acute spinal cord injuries are a common problem in dogs, and due to the poor regenerative capacity of the nervous system, some dogs fail to recover and are left permanently paralyzed and incontinent. Experimental studies in rodents suggest that Glial Growth Factor 2 (GGF2) improves the recovery from a spinal cord injury. The purpose of this clinical trial is to evaluate the safety of GGF2 in dogs with severe spinal cord injuries due to acute intervertebral disc herniations. For more information..

Completed Clinical Trials

Methylprednisolone Sodium Succinate and Polyethylene Glycol in Canine Spinal Cord Injury. *Data analysis is being completed and the results of this study will be submitted for publication shortly

This was a multicenter trial for dogs that suffered an acute spinal cord injury due to a disc herniation. Two different neuroprotective drugs were used compared with placebo in surgically treated dogs. Dogs entered into this trial were paraplegic with no pain sensation in their hind feet, weighed less than 20kg, were between 2 and 10 years, and had suffered the injury within 24 hours of presentation. Sixteen centers across the US were involved in the trial. This trial was funded by Morris Animal Foundation. For more information...

Comparison of the effect of T-BOC, 4-AP and placebo on pelvic limb and bladder function in chronically paraparetic dogs – a blinded study. *Data analysis is being completed and the results of this study will be submitted for publication shortly

This trial evaluated two different potassium channel blockers in chronically paralyzed dogs due to an acute spinal cord injury. Dogs in this trial had been unable to use their hind limbs due to a thoracolumbar spinal cord injury that had occurred at least 6 months previously. This trial was funded by NeuroMetrix Inc. For more information...

Treatment of paraparesis in dogs using a novel derivative of 4-aminopyridine. *19 cases were recruited and a paper is in submission for publication

This trial compared the effect of the t-butyl derivative of 4-AP and placebo on hind limb gait in chronically paraparetic dogs. Dogs entered into this trial must have chronic neurologic deficits in their pelvic limbs as a result of an acute spinal cord injury at least 6 months previously. Some dog had some motor function in their hind limbs, but had an obviously abnormal hind limb gait. This trial was funded by Morris Animal Foundation For more information...

The Effect of Cranberry Extract on Myelopathy-Associated Urinary Tract Infections in Dogs. *Case recruitment is complete and data analysis is ongoing

Spinal cord injuries affect not only movement of the hind limbs, but also the ability to urinate. While dogs recover from a spinal cord injury they are predisposed to develop urinary tract infections (UTIs) because of a failure to empty their bladder completely. Cranberry extract has been shown to reduce the chance of developing a UTI by preventing certain common types of bacteria from adhering to the bladder wall. In this study we compared the effect of cranberry extract with placebo on the incidence of UTIs. This study was funded by Morris Animal Foundation. For more information ...

Treatment of Canine Paralysis with Autologous Adipose Tissue Derived Stem Cells, Schwann Cells & Inosine. *Case recruitment is complete, our last cases are finishing the protocol and data analysis is ongoing

This trial evaluated the effect of combining transplants of autologous (derived from the patient) Schwann cells (SCs) and Adipose Derived Stromal cells (ADSCs) with an inosine infusion in chronically paralyzed dogs. For inclusion in this trial, dogs were unable to use their hind limbs due to a thoracolumbar spinal cord injury that had occurred at least 3 months previously. This trial was funded by Morris animal Foundation. For more information...