Faculty

Thierry Olivry, DrVet, PhD, DipECVD, DipACVD
President, European College of Veterinary Dermatology (ECVD)
Professor, Immunodermatology

Adjunct Research Associate Professor, Department of Dermatology, School of Medicine, University of North Carolina at Chapel Hill

1986 Docteur-Vétérinaire, (Dr.Vet) (cum laude)
Ecole Nationale Vétérinaire de Toulouse,
Université Paul-Sabatier, Toulouse, France

1997: Doctorate in Philosophy (Ph.D.) (Comparative Pathology Major), University of California, Davis, California.

Phone: 919.513.7711
FAX: 919.513.6336
Email: thierry_olivry@ncsu.edu

Specialty

Canine atopic dermatitis and autoimmune diseases (especially pemphigus)

Return to Top

Professional Experience & Qualifications

1995: Diplomate, American College of Veterinary Dermatology (A.C.V.D.)

1993: Diplomate, European College of Veterinary Dermatology (E.C.V.D.)

1992: Educational Commission for Foreign Veterinary Graduates Certificate, American Veterinary Medical Association, Schaumburg, Illinois.

1985: Certification of Superior Studies in Animal Hematology and Clinical Biochemistry, Ecole Nationale Vétérinaire de Toulouse, Université Paul-Sabatier, Toulouse, France

1979 Baccalauréat (Biology) (with honors), Lycée Jean-Zay, Orléans, France

Professional Society Memberships

2000-Present: North Carolina Veterinary Medical Association (N.C.V.M.A.)
Active Membership

1998-Present: International Society of Veterinary Dermatopathology (I.S.V.D.),
Full Membership

1995-Present: American College of Veterinary Dermatology (A.C.V.D.),
Diplomate.

1995-Present: The Society for Investigative Dermatology (S.I.D.),
Active Membership.

1993-Present: European College of Veterinary Dermatology (E.C.V.D.),
Diplomate.

1988-Present: American Academy of Veterinary Dermatology (A.A.V.D.),
Full Membership.

1986-Present: European Society of Veterinary Dermatology (E.S.V.D.),
Full Membership.

Other Current Professional Activities

2004-Present: Member, Executive Board, European College of Veterinary Dermatology

2001-2004: Chair, International Task Force on Canine Atopic Dermatitis

2000-Present: Member, Editorial Board, Veterinary Dermatology

1996-Present:Owner & Manager:
DipDerm listserv (Specialized Veterinary Dermatology Internet Bulletin Board)
VetDerm listserv (Veterinary Dermatology Internet Bulletin Board)

Honors

2005: NC State University Teaching Hospital Clinician of the Year Award, North Carolina Veterinary Medical Association (NCVMA)

2004: American College of Veterinary Dermatology (ACVD) Award of Excellence for Outstanding Contributions to Science and Education

2003: Sigman Xi NCSU Chapter Research Award

2003: Naming of the Dermatology Clinic at the Aristotle University of Thessaloniki, Greece: "Small Animal Dermatological Unit Thierry Olivry," in honor of achievements in the field of veterinary immunodermatology

2000: Paul-Groulade Award (best article in "Prat Med Chir Anim Comp"), French Small Animal Veterinary Association (A.F.V.A.C./C.N.V.S.P.A.), Paris, France

1986: University Distinguished Award (Silver Medal), Ecole Nationale Vétérinaire de Toulouse, Université Paul-Sabatier, Toulouse, France

Return to Top

Research Area

My principal research interests involve investigating the pathogenesis and therapy of canine atopic dermatitis and autoimmune skin diseases. Current projects on atopic dermatitis include clinical trials on the pharmacotherapy of this disease, as well as investigating the genetics of this trait in West Highland White Terriers. My research on autoimmune skin diseases involves the characterization of clinical signs, histopathology and immunological aspects of novel clinico-pathological entities. Additionally, we are investigating the autoantibody response in the blistering disease pemphigus foliaceus in dogs.

Selected Publications

Refereed Articles on Canine Atopic Dermatitis:

Olivry T, Paps JS, Bizikova P, Murphy KM, Jackson HA, Zebala J. 2007. A pilot trial evaluating the efficacy of low dose aminopterin in the canine homologue of human atopic dermatitis. British Journal of Dermatology 157: 1040-3.

Favrot C, Reichmuth P, Olivry T. 2007. Treatment of canine atopic dermatitis with azathioprine: a pilot study. Veterinary Record 160: 520-1.

Olivry T, Marsella R, Iwasaki T, Mueller RS and the International Task Force on Canine Atopic Dermatitis. 2007. Evaluation of CADESI-03, a severity scale for clinical trials enrolling dogs with atopic dermatitis. Veterinary Dermatology18: 79-96.

Olivry T, Kurata K, Paps JS, Masuda K. 2007. A blinded randomized controlled trial evaluating the usefulness of a novel diet (Aminoprotect Care) in dogs with spontaneous food allergy. Journal of Veterinary Medical Science 69: 1025-31.

Marsella R, Olivry T, Maeda S. 2006. Cellular and cytokine kinetics after epicutaneous allergen challenge (atopy patch testing) with house dust mites in high IgE Beagles. Veterinary Dermatology 17: 111-20.

Olivry T, DeAngelo KB, Dunston SM, Clarke KB, McCall CA. 2006. Patch testing of experimentally sensitized beagle dogs: development of a model for skin lesions of atopic dermatitis. Veterinary Dermatology 17: 95-102.

Pucheu-Haston CM, Shuster D, Olivry T, Brianceau P, Lockwood P, McClanahan T, De Waal Malefyt R, Mattson JD, Hammerberg B. 2006. A canine model of cutaneous late phase reactions: prednisolone inhibition of cellular and cytokine responses. Immunology 117: 177-87.

Marsella R, Olivry T, Nicklin CF, Lopez J. 2006. Pilot investigations of a model for canine atopic dermatitis: environmental house dust mite challenge of high-IgE-producing beagles, mite hypersensitive dogs with atopic dermatitis and normal dogs. Veterinary Dermatology 17; 24-35.

Olivry T, Marsella R, Maeda S, Pucheu-Haston CM, Hammerberg B. 2005. Mechanism of lesion formation in canine atopic dermatitis: 2004 hypothesis. In: Hillier A, Foster AP, Kwochka KW (eds): Advances in Veterinary Dermatology, volume 5. Blackwell Publishing, Oxford, UK: 10-6.

Olivry T, Jackson HA, Murphy KM, Tater KC, Roberts M. 2005. Evaluation of a point-of-care immunodot assay for predicting results of allergen-specific intradermal and immunoglobulin E serological tests.  Veterinary Dermatology 16: 117-20.

Bensignor E, Olivry T. 2005. Treatment of localized lesions of canine atopic dermatitis with tacrolimus ointment: a blinded randomized controlled trial. Veterinary Dermatology 16: 52-60.

Weber E, Hunter S, Stedman K, Olivry T, Hillier A, McCall C. 2003. Identification, char-acterization and cloning of a complementary DNA encoding a 60-kD house dust mite al-lergen (Der f 18) for human beings and dogs. Journal of Allergy and Clinical Immunology 112: 79-86.

Olivry T, Mueller RS and the International Task Force on Canine Atopic Dermatitis. 2003. Evidence-based veterinary dermatology: a systematic review on the pharmacother-apy of canine atopic dermatitis. Veterinary Dermatology 14: 121-46.

Marsella R, Olivry T. 2003. Animal models of atopic dermatitis. Clinics in Dermatology 21: 122-33.

Olivry T, Dunston SM, Rivierre C, Jackson HA, Murphy KM, Peters E, Dean GA. 2003. A randomized controlled trial of misoprostol monotherapy for canine atopic derma-titis: effects on dermal cellularity and cutaneous tumor necrosis factor-alpha. Veterinary Dermatology 14: 37-46.

Olivry T, Steffan J, Fisch RD, Prélaud P, Guaguère E, Fontaine J, Carlotti DN, and the European Veterinary Dermatology Cyclosporine Group. 2002. Randomized controlled trial of the efficacy of cyclosporine in the treatment of atopic dermatitis in dogs. Journal of the American Veterinary Medical Association 221: 370-7.

Olivry T, Rivierre C, Jackson HA, Murphy KM, Davidson G, Sousa CA. 2002. Cyclosporine decreases skin lesions and pruritus in dogs with atopic dermatitis: a blinded randomized prednisolone controlled trial. Veterinary Dermatology 13: 77-87.

Inman AO, Olivry T, Dunston SM, Monteiro-Rivierre NA, Gatto H. 2001. Electron microscopic observations of the stratum corneum intercellular lipids in normal and atopic dogs. Veterinary Pathology 38:720-3.

Hammerberg B, Olivry T, Orton SM. 2001. Skin mast cell histamine release following stem cell factor and high-affinity IgE receptor cross-linking in dogs with atopic dermatitis. Veterinary Dermatology 12: 339-46.

Olivry T, DeBoer DJ, Griffin CE, Halliwell REW, Hill PB, Hillier A, Marsella R, Sousa CA. 2001. The ACVD task force on canine atopic dermatitis: forewords and lexicon. Veterinary Immunology and Immunopathology 81: 143-6.

Hill PB, Olivry T. 2001. The ACVD task force on canine atopic dermatitis (V): biology and role of inflammatory cells in cutaneous allergic reactions. Veterinary Immunology and Immunopathology 81: 169-86.

Hill PB, Hillier A, Olivry T. 2001. The ACVD task force on canine atopic dermatitis (VI): IgE-induced immediate and late-phase reactions, two inflammatory sequences at sites of intradermal allergen injections. Veterinary Immunology and Immunopathology 81: 199-204.

Marsella R, Olivry T. 2001. The ACVD task force on canine atopic dermatitis (VII): Mediators of inflammation in canine atopic dermatitis. Veterinary Immunology and Immunopathology 81: 205-14.

Olivry T, Hill PB. 2001. The ACVD task force on canine atopic dermatitis (VIII): Is the epidermal lipid barrier defective ? Veterinary Immunology and Immunopathology 81: 215-8.

Olivry T, Hill PB. 2001. The ACVD task force on canine atopic dermatitis (IX): The controversy surrounding the route of allergen challenge in canine atopic dermatitis. Veterinary Immunology and Immunopathology 81: 219-26.

Olivry T, Hill PB. 2001. The ACVD task force on canine atopic dermatitis (XVIII): Histopathology of skin lesions. Veterinary Immunology and Immunopathology 81: 305-10.

Olivry T, Sousa CA. 2001. The ACVD task force on canine atopic dermatitis (XIX): General principles of therapy. Veterinary Immunology and Immunopathology 81: 311-6.

Olivry T, Sousa CA. 2001. The ACVD task force on canine atopic dermatitis (XX): Glucocorticoid pharmacotherapy. Veterinary Immunology and Immunopathology 81: 317-22.

Marsella R, Olivry T. 2001. The ACVD task force on canine atopic dermatitis (XXII): Nonsteroidal anti-inflammatory pharmacotherapy. Veterinary Immunology and Immunopathology 81: 331-46.

Olivry T, Marsella R, Hillier A. 2001. The ACVD task force on canine atopic dermatitis (XXIII): Are essential fatty acid effective? Veterinary Immunology and Immunopathology 81: 347-62.

Fontaine J, Olivry T. 2001. Treatment of canine atopic dermatitis with cyclosporine: a pilot clinical study. Veterinary Record 148: 662-3.

McCall C, Hunter S, Stedman K, Weber E, Hillier A, Bozic C, Rivoire B, Olivry T. 2001. Characterization and cloning of a major high molecular weight house dust mite allergen (Der f 15) for dogs. Veterinary Immunology and Immunopathology 78: 231-47.

Olivry T, Dunston SM, Murphy KM, Moore PF. 2001. Characterization of the inflammatory infiltrate during IgE-mediated late phase reactions in normal and atopic dogs. Veterinary Dermatology 12: 49-58.

Rivierre C, Dunston SM, Olivry T. 2000. Effects of a 1 per cent hydrocortisone conditioner on the prevention of immediate and late-phase reactions in canine skin. Veterinary Record 147: 739-42.

Olivry T, Dean GA, Tompkins MB, Dow JL, Moore PF. 1999. Toward a canine model of atopic dermatitis: amplification of cytokine gene transcripts in the skin of atopic dogs. Experimental Dermatology 8: 204-11.

Welle M, Olivry T, Grimm S, Suter MM. 1999. Mast cell density and subtypes in the skin of dogs with atopic dermatitis. Journal of Comparative Pathology 120: 187-97.

Prélaud P, Olivry T. 1998. Bimodal activation of peripheral blood basophil granulocytes in canine atopic dermatitis. Revue de Medecine Vétérinaire 149: 1121-4.

Prélaud P, Olivry T. 1998. Etiopathogénie de la dermatite atopique canine (Etiopathogenesis of canine atopic dermatitis). Pratique Médicale et Chirurgicale de l'Animal de Compagnie 33: S315-29.

Hammerberg B, Bevier DE, DeBoer, DJ, Olivry T, Orton SM, Gebhard D, Vaden SL. 1997. Auto IgG anti-IgE and IgGxIgE immune complex presence and effects on ELISA-based quantitation of IgE in canine atopic dermatitis, demodectic acariasis and helminthiasis. Veterinary Immunology and Immunopathology 60: 33-46.

Olivry T, Guaguère E, Héripret D. 1997. Treatment of canine atopic dermatitis with misoprostol, a prostaglandin E1 analogue: an open study. Journal of Dermatological Treatment 8: 243-7.

Olivry T, Moore PF, Naydan DK. 1997. Characterization of the cutaneous inflammatory infiltrate in canine atopic dermatitis. American Journal of Dermatopathology 19: 477-86.

Olivry T, Moore PF, Affolter VK, Naydan DK. 1996. Langerhans cell hyperplasia and IgE expression in canine atopic dermatitis. Archives of Dermatological Research 288: 579-85.

Return to Top

Refereed Articles on Blistering Skin Diseases:

Heimann M, Beco L, Petein M, Nishifuji K, Amagai M, Olivry T. 2007. Canine hyperplastic intraepidermal pustular and suprabasal acantholytic dermatosis with features of human pemphigus vegetans. Veterinary Pathology 44: 550-5. (Corresponding Author)

Nishifuji K, Olivry T, Ishii K, Iwasaki T, Amagai M. 2007. IgG autoantibodies directed against desmoglein 3 cause dissociation of keratinocytes in canine pemphigus vulgaris and paraneoplastic pemphigus. Veterinary Immunology and Immunopathology 117: 209-21.

Williamson L, Suter MM, Olivry T, Wyder M, Müller EJ. 2007. Upregulation of c-Myc may contribute to the pathogenesis of canine pemphigus vulgaris. Veterinary Dermatology 18: 12-7.

Olivry T, LaVoy A, Dunston SM, Brown RS, Lennon EM, Warren SJ, Prisayanh P, Müller E, Suter M. 2006. Desmoglein-1 is a minor autoantigen in dogs with pemphigus foliaceus. Veterinary Immunology and Immunopathology 110: 245-55.

Elmore SA, Basseches J, Anhalt GJ, Cullen JM, Olivry T. 2005. Paraneoplastic pemphigus in a dog with splenic sarcoma. Veterinary Pathology 42: 88-91.

Jackson HA, Olivry T, Berget F, Dunston SM, Bonnefond C, Chabanne L. 2004. Immunopathology of vesicular cutaneous lupus erythematosus in the rough collie and Shetland sheepdog: a canine homologue of subacute cutaneous lupus erythematosus. Veterinary Dermatology 15: 230-9. (Major Contributor)

Olivry T, Bergvall KE, Atlee BA. 2004. Prolonged remission after immunosuppressive therapy in six dogs with pemphigus foliaceus. Veterinary Dermatology 15: 245-52.

Xu L, Olivry T, Chan LS. 2004. Molecular cloning of a cDNA encoding the porcine type XVII collagen non-collagenous 16A domain and localization of the domain to the upper part of porcine skin basement membrane zone. Veterinary Dermatology 15: 146-51.

Honda R, Nishifugi K, Olivry T, White SD, Momoi Y, Iwasaki T. 2004. Detection of circulating antibodies using living keratinocyte staining on MCA-B1 in dogs with pemphigus foliaceus. Research in Veterinary Sciences 77: 105-13.

Olivry T, Joubeh S, Dunston SM, Nishiyama T, Ghohestani RF. 2003. Desmoglein-3 is a target autoantigen in spontaneous canine pemphigus vulgaris. Experimental Dermatology 12: 198-203.

Favrot C, Dunston SM, Paradis M, Olivry T. 2003. Isotype determination of circulating autoantibodies in canine autoimmune subepidermal blistering dermatoses. Veterinary Dermatology 14: 23-30. (Graduate Student First Author)

Olivry T, Rivierre C, Murphy KM. 2003. Efficacy of cyclosporine for treatment induc-tion of canine pemphigus foliaceus. Veterinary Record 152: 53-4.

Olivry T, Dunston SM, Zhang G, Ghohestani RF. 2002. Laminin-5 is targeted by autoantibodies in feline mucous membrane (cicatricial) pemphigoid. Veterinary Immunology and Immunopathology 88: 123-9.

Favrot C, Dunston SM, Deslandes J, Paradis M, Olivry T. 2002. Effect of substrate selection on indirect immunofluorescence testing of canine autoimmune subepidermal blistering diseases. Canadian Journal of Veterinary Research 66: 26-30.

Rivierre C, Olivry T. 2002. Nouvelles dermatoses auto-immunes du chien et du chat – Deuxième partie: maladies ayant pour cible les protéines de la membrane basale (novel autoimmune skin diseases of dogs and cats – second part: diseases targeting basement membrane proteins). Pratique Médicale et Chirurgicale des Animaux de Compagnie. 37: 11-21.

Rivierre C, Olivry T. 2001. Nouvelles dermatoses auto-immunes du chien et du chat – Première partie: maladies ayant pour cible le follicule pileux et les kératinocytes basaux (new autoimmune skin diseases of dogs and cats – first part: diseases targeting hair follicles and basal keratinocytes). Pratique Médicale et Chirurgicale des Animaux de Compagnie 36:635-44.

Olivry T, Jackson HA. 2001. Diagnosing new autoimmune blistering skin diseases of dogs and cats. Clinical Techniques in Small Animal Practice 16: 225-9.

Olivry T, Chan LS. 2001. Autoimmune blistering dermatoses in domestic animals. Clinics in Dermatology 19:750-60.

Olivry T, Jackson HA. 2001. An alopecic phenotype of canine pemphigus vulgaris? British Journal of Dermatology 145: 176-7.

Olivry T, Dunston SM, Schachter M, Xu L, Nguyen N, Marinkovich MP, Chan LS. 2001. A spontaneous canine model of mucous membrane (cicatricial) pemphigoid, an autoimmune blistering disease affecting mucosae and mucocutaneous junctions. Journal of Autoimmunity 16: 411-21.

Foster AP, Olivry T. 2001. Nasal dermatitis as a manifestation of canine pemphigus vulgaris. Veterinary Record 148: 450-1.

Jackson HA, Olivry T. 2001. Ulcerative dermatosis of the Shetland Sheepdog and Rough Collie may represent a novel vesicular variant of cutaneous lupus erythematosus. Veterinary Dermatology 12: 19-28.

Olivry T, Alhaidari Z, Ghohestani RF. 2000. Anti-plakin and desmoglein autoantibodies in a dog with pemphigus vulgaris. Veterinary Pathology 37: 496-9.

Brenneman KA, Olivry T, Dorman DC. 2000. Rudimentary hemidesmosome formation in congenital generalized (Herlitz) junctional epidermolysis bullosa in the Sprague-Dawley Rat. Veterinary Pathology 37:336-9.

Olivry T, Dunston SM, Fahey M, Nguyen N, Marinkovich MP. 2000. Autoantibodies against the processed ectodomain of collagen XVII (BPAG2, BP180) define a canine homologue of linear IgA disease of humans. Veterinary Pathology 37: 302-9

Mirsky ML, Singleton W, Olivry T. 2000. Spontaneous cutaneous vesicular disease in Yucatan minipigs. Toxicologic Pathology 28: 357-8.

Olivry T, Petersen A, Dunston SM, Chen M. 2000. A novel localized variant of canine epidermolysis bullosa acquisita. Veterinary Record 146: 193-4.

Olivry T, Mirsky ML, Singleton W, Dunston SM, Borrillo AKG, Xu L, Traczyk T, Rosolia DL, Chan LS. 2000. A spontaneously arising porcine model of bullous pemphigoid. Archives of Dermatological Research 292: 37-45.

Olivry T, Borrillo AKG, Xu L, Dunston SM, Slovis NM, Affolter VK; DeManuelle TC, Chan LS. 2000. Equine bullous pemphigoid IgG autoantibodies target linear epitopes in the NC16A ectodomain of collagen XVII (BP180, BPAG2). Veterinary Immunology and Immunopathology 73: 45-52.

Xu L, O'Toole EA, Olivry T, Hernandez C, Peng J, Chen M, Chan LS. 2000. Molecular cloning of canine bullous pemphigoid antigen 2 cDNA and immunomapping of NC16A domain by canine bullous pemphigoid autoantibodies. Biochimica and Biophysica Acta 1500:97-107

Olivry T, Dunston SM, Marinkovich MP. Reduced anchoring fibril formation and collagen VII immunoreactivity in feline dystrophic epidermolysis bullosa. 1999. Veterinary Pathology 36: 616-8

Olivry T, Savary KCM, Murphy KM, Dunston SM, Chen M. 1999. Bullous systemic lupus erythematosus (Type I) in a dog. Veterinary Record 145: 165-9

Olivry T, Chan LS, Xu L, Chace P, Dunston SM, Fahey M, Marinkovich MP. 1999. Novel feline autoimmune blistering disease resembling bullous pemphigoid in humans: IgG autoantibodies target the NC16A ectodomain of collagen XVII (BP180 / BPAG2). Veterinary Pathology 36: 328-35.

Olivry T, Fine J-D, Dunston SM, Pascal Tenorio A, Chasse D, Monteiro-Riviere NA, Chen M, Woodley DT. 1998. Canine epidermolysis bullosa acquisita: circulating autoantibodies target collagen VII epitopes. Veterinary Dermatology 9: 19-31.

International Task Force on Canine Atopic Dermatitis

Download PDF-formatted CADESI-03
Download Excel-formatted CADESI-03

Links of Interest

American Academy of Veterinary Dermatology
American College of Veterinary Dermatology
European College of Veterinary Dermatology
European Society of Veterinary Dermatology

Return to Top