Microbiology and Immunology
Office: Main Building, D-344
Comparative Immunology Research Laboratory
Jonathan E. Fogle DVM, PhD, DACVIM
CVM Main Building Room B323
Mrs. Beth Thompson, Research Specialist
VMP 912 Evidence Based Medicine: Group Facilitator
VMP 920 Infection and Immunity: Instructor
VMP 921 Infection and Immunity: Course Co-coordinator
VMP 978 Clinical Pathology, Parasitology and Immunology: Instructor
IMM 816 Advanced Topics In Immunology and Biotechnology: Facilitator
VMP 991 Immunodiagnostics Selective: Course Coordinator
Director, Clinical Immunology Laboratory, North Carolina State University College of Veterinary Medicine
Director, Flow Cytometry and Cell Sorting Core Facility, North Carolina State University
Investigator: The role of CD4+CD25+ T regulatory cell suppression on CD8+ lymphocyte responses during acute and chronic FIV infection and mechanisms of CD8+ lymphocyte anergy (NIH 1K08AI074445-01A1).
Co-investigator: The role of the TGF-b signaling pathway in mediating Treg cell suppression of the immune response to FIV infection. R01 AI080288 (M. Tompkins- PI)
Investigator: Soluble C14 as a biomarker for bacterial translocation. The Clinical Immunology facility, in collaboration with the Clinical Studies Core and Equine Health Sciences Program at the NCSU-CVM, is conducting a study to assess the utility of sCD14 as a biomarker for bacterial translocation in horses, dogs and cats.
Co-investigator: Phenotypic and functional characterization of differences between monocytes in dogs with and without osteosarcoma. The purpose of this study is to acquire a deeper understanding of the heterogeneity of canine monocytes by defining monocyte subpopulations, with specific emphasis on monocytes in dogs with osteosarcoma that also have an infected surgical site.
Thalheim LLN, Suter SE, Borst L, Fogle JE,Williams L. Lymphoma immunophenotype of dogs determined by immunohistochemistry, flow cytometry, and polymerase chain reaction for antigen receptor rearrangements. accepted J Vet Intern Med, August 2013
Meng L, Tompkins MB, Miller MM, Fogle JE.Lentivirus-activated T regulatory cells suppress T helper cell IL2 production by inhibiting NFAT2 binding to the IL2 promoter. AIDS Res Hum Retroviruses. 2013 Aug 7. [Epub ahead of print] PMID: 23924068
Miller M.M., Fogle J.E., Tompkins M.B Infection with Feline Immunodeficiency Virus Directly Activates CD4+CD25+ T Regulatory Cells. epub ahead of print, Journal of Virology 2013. 10.1128/JVI.00996-13 JVI.00996-13, PMID: 23760252
Miller M.M., Fogle J.E., Tompkins M.B. Feline Glycoprotein A Repetitions Predominant (GARP) anchors TGFb on the surface of CD4+CD25+ regulatory T cells and mediates lentivirus induced T cell immunodeficiency. Accepted, AIDS Res Hum Retroviruses, Jan 2013.
Miller M.M., Thompson E. M., Suter S. E., Fogle J.E. CD8+ clonality is associated with prolonged acute plasma viremia and altered mRNA cytokine profiles during the course of Feline Immunodeficiency Virus infection. Vet Immunol Immunopathol e-pub ahead of print, 2012.
Sibley TA, Miller MM, Fogle JE. Human intravenous immunoglobulin (hIVIG) inhibits anti-CD32 antibody binding to canine DH82 cells and canine monocytes in vitro. Vet Immunol Immunopathol, e-pub ahead of print, 2012.
Miller M.M., Fogle J.E. Administration of Fozivudine Tidoxil as a Single-Agent Therapeutic during Acute Feline Immunodeficiency Virus Infection Does Not Alter Chronic Infection. Viruses. 2012; 4(6):954-962.
Fogle, J.E., Tompkins, W.A., Campbell B., Sumner D., Tompkins, M.B. Fozivudine tidoxil as a single agent therapy reduces plasma and cell associated viremia during acute feline immunodeficiency virus infection. J Vet Intern Med Vol. 25 (3) May / June 2011.
Fogle, J.E., Tompkins, W.A., Tompkins, M.B. CD4+CD25+ T regulatory cells from FIV+ cats induce a unique anergic profile in CD8+ lymphocyte targets. Retrovirology 7:97 Nov 2010.
Fogle, J.E., Mexas, A.M., Tompkins, W.A., Tompkins, M.B. CD4+CD25+ T regulatory cells inhibit CD8+ IFNg production during acute and chronic FIV infection utilizing a membrane TGFβ dependent mechanism. AIDS Res Hum Retroviruses., 26(2):201-16. Feb 2010.
Mexas AM, Fogle JE, Tompkins WA, Tompkins MB. CD4+CD25+ Regulatory T cells are Infected and Activated During Acute FIV Infection. Vet Immunol Immunopathol, 126(3-4) 2008.
Smithberg SR, Fogle JE*, Mexas AM, Reckling SK, Lankford SM, Tompkins MB, and Dean GA. In vivo depletion of CD4+CD25+ regulatory T cells in cats. J Immunol Methods., Jan 2008 (*co-primary author)
Fogle, JE, Bissett, SA. Mucosal Immunity and Canine Idiopathic Enteropathies. Comp Cont Ed Pract Vet: Volume 29(5) May 2007.
Fogle, JE, Bissett, SA. Cholangiohepatitis in Cats. Standards of Care- Emerg Crit Care Med: Vol 7.4 May 2005.
Fogle, JE. Pit Viper Envenomation in Dogs. Standards of Care- Emerg Crit Care Med: Vol 6.8 Sep 2004.
Tompkins WA, Tompkins MB, Mexas AM, Fogle JE. CD4+CD25+ Regulatory T Cells in Viral Infections. In Regulatory T cells and Clinical Application. Springer, 2008.