Jonathan Fogle, DVM, PhD
Microbiology and Immunology
Office: B-332, CVM Main Building
Comparative Immunology Research Laboratory
Jonathan E. Fogle DVM, PhD, DACVIM
CVM Main Building Room B323
- VMP 920 Infection and Immunity
- VMP 921 Infection and Immunity
- VMP 978 Clinical Pathology, Parasitology and Immunology
- VMP 991 Immunodiagnostics Selective
- IMM 816 Advanced Topics In Immunology and Biotechnology: Facilitator
- PhD, Immunology, North Carolina State University
- Diplomate, American College of Veterinary Internal Medicine
- Clinical Studies/ECFVG Certification, Louisiana State University
- DVM, Ross University School of Veterinary Medicine
- BS, Veterinary Science, University of Arizona
Director, Clinical Immunology Laboratory, North Carolina State University College of Veterinary Medicine
Director, Flow Cytometry and Cell Sorting Core Facility, North Carolina State University
Investigator: Creative and Novel Ideas in HIV Research (CNIHR) Award
Title: Epigenetic modulation rescues virus-specific CD8+ T cells from
T regulatory cell suppression.
Description: These studies are aimed at identifying the mechanisms of
CD8+ T cell suppression and how to rescue virus-specific CD8+
proliferation using the FIV model for HIV.
Investigator: R21 LM11A-31 (Meeker, PI)
Title: LM11A-31 neuroprotective efficacy in an animal model of HIV
Description: Examination of a novel compound LM11A-31 for
neuro-protective effects using the FIV model
Investigator: Soluble C14 as a biomarker for bacterial translocation. The Clinical Immunology facility, in collaboration with the Clinical Studies Core and Equine Health Sciences Program at the NCSU-CVM, is conducting a study to assess the utility of sCD14 as a biomarker for bacterial translocation in horses, dogs and cats.
Co-investigator: Phenotypic and functional characterization of differences between monocytes in dogs with and without osteosarcoma. The purpose of this study is to acquire a deeper understanding of the heterogeneity of canine monocytes by defining monocyte subpopulations, with specific emphasis on monocytes in dogs with osteosarcoma that also have an infected surgical site.
CD4+CD25+ T regulatory cells activated during Feline Immunodeficiency Virus infection convert T helper cells into functional suppressors through a membrane-bound TGFβ/ GARP-mediated mechanism. Miller MM, Petty CS, Tompkins MB, Fogle JE. Virol J. 2014 Jan 18;11:7. doi: 10.1186/1743-422X-11-7.
Thalheim LLN, Suter SE, Borst L, Fogle JE, Williams L. Lymphoma
immunophenotype of dogs determined by immunohistochemistry, flow
cytometry, and polymerase chain reaction for antigen receptor
rearrangements. J Vet Intern Med. 2013 Nov-Dec;27(6):1509-16. doi:
10.1111/jvim.12185. Epub 2013 Sep 20.PMID:24112291
Meng L, Tompkins MB, Miller MM, Fogle JE. Lentivirus-activated T
regulatory cells suppress T helper cell IL2 production by inhibiting
NFAT2 binding to the IL2 promoter. AIDS Res Hum Retroviruses. 2013 Aug 7. [Epub ahead of print] PMID: 23924068
Miller M.M., Fogle J.E., Tompkins M.B Infection with Feline
Immunodeficiency Virus Directly Activates CD4+CD25+ T Regulatory
Cells. epub ahead of print, Journal of Virology 2013.
10.1128/JVI.00996-13 JVI.00996-13, PMID: 2376025
Miller M.M., Fogle J.E., Tompkins M.B. Feline Glycoprotein A
Repetitions Predominant (GARP) anchors TGFb on the surface of
CD4+CD25+ regulatory T cells and mediates lentivirus induced T cell
immunodeficiency. AIDS Res Hum Retroviruses. 2013 Apr;29(4):641-51. PMID: 23373523
Miller M.M., Thompson E. M., Suter S. E., Fogle J.E. CD8+ clonality
is associated with prolonged acute plasma viremia and altered mRNA
cytokine profiles during the course of Feline Immunodeficiency Virus
infection. 2013 Apr 15;152(3-4):200-8. PMID: 23332729
Sibley TA, Miller MM, Fogle JE. Human intravenous immunoglobulin
(hIVIG) inhibits anti-CD32 antibody binding to canine DH82 cells and
canine monocytes in vitro. Vet Immunol Immunopathol. 2013 Feb
15;151(3-4):229-34. PMID: 23276750
Miller M.M., Fogle J.E. Administration of Fozivudine Tidoxil as a Single-Agent Therapeutic during Acute Feline Immunodeficiency Virus Infection Does Not Alter Chronic Infection. Viruses. 2012; 4(6):954-962.
Fogle, J.E., Tompkins, W.A., Campbell B., Sumner D., Tompkins, M.B. Fozivudine tidoxil as a single agent therapy reduces plasma and cell associated viremia during acute feline immunodeficiency virus infection. J Vet Intern Med Vol. 25 (3) May / June 2011.
Fogle, J.E., Tompkins, W.A., Tompkins, M.B. CD4+CD25+ T regulatory cells from FIV+ cats induce a unique anergic profile in CD8+ lymphocyte targets. Retrovirology 7:97 Nov 2010.
Fogle, J.E., Mexas, A.M., Tompkins, W.A., Tompkins, M.B. CD4+CD25+ T regulatory cells inhibit CD8+ IFNg production during acute and chronic FIV infection utilizing a membrane TGFβ dependent mechanism. AIDS Res Hum Retroviruses., 26(2):201-16. Feb 2010.
Mexas AM, Fogle JE, Tompkins WA, Tompkins MB. CD4+CD25+ Regulatory T cells are Infected and Activated During Acute FIV Infection. Vet Immunol Immunopathol, 126(3-4) 2008.
Smithberg SR, Fogle JE*, Mexas AM, Reckling SK, Lankford SM, Tompkins MB, and Dean GA. In vivo depletion of CD4+CD25+ regulatory T cells in cats. J Immunol Methods., Jan 2008 (*co-primary author)
Fogle, JE, Bissett, SA. Mucosal Immunity and Canine Idiopathic Enteropathies. Comp Cont Ed Pract Vet: Volume 29(5) May 2007.
Fogle, JE, Bissett, SA. Cholangiohepatitis in Cats. Standards of Care- Emerg Crit Care Med: Vol 7.4 May 2005.
Fogle, JE. Pit Viper Envenomation in Dogs. Standards of Care- Emerg Crit Care Med: Vol 6.8 Sep 2004.
Tompkins WA, Tompkins MB, Mexas AM, Fogle JE. CD4+CD25+ Regulatory T Cells in Viral Infections. In Regulatory T cells and Clinical Application. Springer, 2008.