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Jonathan Fogle, DVM, PhD

Joanathan Fogle

Microbiology and Immunology
Assistant Professor

Office: B-332, CVM Main Building
Phone: 919-513-6248
Fax: 919-513-6464
Email: jefogle@ncsu.edu

Comparative Immunology Research Laboratory
Jonathan E. Fogle DVM, PhD, DACVIM
CVM Main Building Room B323
Dan Bogan
919-513-6393
djbogan@ncsu.edu

Course Involvement

  • VMP 920 Infection and Immunity
  • VMP 921 Infection and Immunity
  • VMP 978 Clinical Pathology, Parasitology and Immunology
  • VMP 991 Immunodiagnostics Selective

Graduate Courses

  • IMM 816 Advanced Topics In Immunology and Biotechnology: Facilitator

Education/Training

  • PhD, Immunology, North Carolina State University
  • Diplomate, American College of Veterinary Internal Medicine
  • Clinical Studies/ECFVG Certification, Louisiana State University
  • DVM, Ross University School of Veterinary Medicine
  • BS, Veterinary Science, University of Arizona

 

Extension

Director, Clinical Immunology Laboratory, North Carolina State University College of Veterinary Medicine

http://www.cvm.ncsu.edu/dphp/labs/clinicalimmunologylab.html

Director, Flow Cytometry and Cell Sorting Core Facility, North Carolina State University

http://www.cvm.ncsu.edu/ccmtr/flocyt.html

Research

Investigator: Creative and Novel Ideas in HIV Research (CNIHR) Award
Title: Epigenetic modulation rescues virus-specific CD8+ T cells from
T regulatory cell suppression.
Description: These studies are aimed at identifying the mechanisms of
CD8+ T cell suppression and how to rescue virus-specific CD8+
proliferation using the FIV model for HIV.
Role: PI

Investigator: R21 LM11A-31 (Meeker, PI)
Title: LM11A-31 neuroprotective efficacy in an animal model of HIV
Description: Examination of a novel compound LM11A-31 for
neuro-protective effects using the FIV model
Role: Co-I

Investigator: Soluble C14 as a biomarker for bacterial translocation.  The Clinical Immunology facility, in collaboration with the Clinical Studies Core and Equine Health Sciences Program at the NCSU-CVM, is conducting a study to assess the utility of sCD14 as a biomarker for bacterial translocation in horses, dogs and cats.

Co-investigator: Phenotypic and functional characterization of differences between monocytes in dogs with and without osteosarcoma. The purpose of this study is to acquire a deeper understanding of the heterogeneity of canine monocytes by defining monocyte subpopulations, with specific emphasis on monocytes in dogs with osteosarcoma that also have an infected surgical site. 

Selected Publications

CD4+CD25+ T regulatory cells activated during Feline Immunodeficiency Virus infection convert T helper cells into functional suppressors through a membrane-bound TGFβ/ GARP-mediated mechanism.  Miller MM, Petty CS, Tompkins MB, Fogle JE.  Virol J. 2014 Jan 18;11:7. doi: 10.1186/1743-422X-11-7.

Thalheim LLN, Suter SE, Borst L, Fogle JE, Williams L.  Lymphoma
immunophenotype of dogs determined by immunohistochemistry, flow
cytometry, and polymerase chain reaction for antigen receptor
rearrangements.  J Vet Intern Med. 2013 Nov-Dec;27(6):1509-16. doi:
10.1111/jvim.12185. Epub 2013 Sep 20.PMID:24112291

 Meng L, Tompkins MB, Miller MM, Fogle JE. Lentivirus-activated T
regulatory cells suppress T helper cell IL2 production by inhibiting
NFAT2 binding to the IL2 promoter. AIDS Res Hum Retroviruses. 2013 Aug 7. [Epub ahead of print] PMID: 23924068

Miller M.M., Fogle J.E., Tompkins M.B Infection with Feline
Immunodeficiency Virus Directly Activates CD4+CD25+ T Regulatory
Cells. epub ahead of print, Journal of Virology 2013.
10.1128/JVI.00996-13 JVI.00996-13, PMID: 2376025

Miller M.M., Fogle J.E., Tompkins M.B. Feline Glycoprotein A
Repetitions Predominant (GARP) anchors TGFb on the surface of
CD4+CD25+ regulatory T cells and mediates lentivirus induced T cell
immunodeficiency. AIDS Res Hum Retroviruses. 2013 Apr;29(4):641-51. PMID: 23373523

Miller M.M., Thompson E. M., Suter S. E., Fogle J.E. CD8+ clonality
is associated with prolonged acute plasma viremia and altered mRNA
cytokine profiles during the course of Feline Immunodeficiency Virus
infection. 2013 Apr 15;152(3-4):200-8.  PMID: 23332729

Sibley TA, Miller MM, Fogle JE.  Human intravenous immunoglobulin
(hIVIG) inhibits anti-CD32 antibody binding to canine DH82 cells and
canine monocytes in vitro. Vet Immunol Immunopathol. 2013 Feb
15;151(3-4):229-34. PMID: 23276750

Miller M.M., Fogle J.E. Administration of Fozivudine Tidoxil as a Single-Agent Therapeutic during Acute Feline Immunodeficiency Virus Infection Does Not Alter Chronic Infection. Viruses. 2012; 4(6):954-962.

Fogle, J.E., Tompkins, W.A., Campbell B., Sumner D., Tompkins, M.B. Fozivudine tidoxil as a single agent therapy reduces plasma and cell associated viremia during acute feline immunodeficiency virus infection. J Vet Intern Med Vol. 25 (3) May / June 2011.

Fogle, J.E., Tompkins, W.A., Tompkins, M.B. CD4+CD25+ T regulatory cells from FIV+ cats induce a unique anergic profile in CD8+ lymphocyte targets. Retrovirology 7:97 Nov 2010.

Fogle, J.E., Mexas, A.M., Tompkins, W.A., Tompkins, M.B. CD4+CD25+ T regulatory cells inhibit CD8+ IFNg production during acute and chronic FIV infection utilizing a membrane TGFβ dependent mechanism. AIDS Res Hum Retroviruses., 26(2):201-16. Feb 2010.

Mexas AM, Fogle JE, Tompkins WA, Tompkins MB. CD4+CD25+ Regulatory T cells are Infected and Activated During Acute FIV Infection. Vet Immunol Immunopathol, 126(3-4) 2008.

Smithberg SR, Fogle JE*, Mexas AM, Reckling SK, Lankford SM, Tompkins MB, and Dean GA.  In vivo depletion of CD4+CD25+ regulatory T cells in cats.  J Immunol Methods., Jan 2008 (*co-primary author)

Fogle, JE, Bissett, SA. Mucosal Immunity and Canine Idiopathic Enteropathies. Comp Cont Ed Pract Vet: Volume 29(5) May 2007.

Fogle, JE, Bissett, SA.  Cholangiohepatitis in Cats.  Standards of Care- Emerg Crit Care Med: Vol 7.4 May 2005.

Fogle, JE. Pit Viper Envenomation in Dogs. Standards of Care- Emerg Crit Care Med: Vol 6.8 Sep 2004.

Book Chapters

Tompkins WA, Tompkins MB, Mexas AM, Fogle JE. CD4+CD25+ Regulatory T Cells in Viral Infections.  In Regulatory T cells and Clinical Application.  Springer, 2008.