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Megan Jacob, PhD

JacobMicrobiology
Assistant Professor
Director, Clinical Microbiology Laboratory

Office: C-340, CVM Main Building
Phone: (919) 513-6236
Fax: (919) 513-6464
E-mail: megan_jacob@ncsu.edu

 

Clinical Microbiology Laboratory: http://www.cvm.ncsu.edu/vth/clin_path_lab.html

Course Involvement

Education/Training

Research Interests:

Food safety remains an important national priority; understanding risk factors associated with increased pathogen shedding in food animals and other processes that affect the transmission and spread of these pathogens throughout the food production chain are my primary research interests.   In addition, in collaboration with the Clinical Microbiology Laboratory, we are involved with research of interest to clinicians and others in the Veterinary Teaching Hospital as well as studying emerging bacterial diseases, antimicrobial susceptibility profiles of hospital patients, and new diagnostic assays. 

Selected Publications:

  1. Hutchins, R. G., S. L. Vaden, M. E. Jacob, T. L. Harris, K. D. Bowles, M. W. Wood, and C. S. Bailey*. 2014. Vaginal microbiota of spayed dogs with or without recurrent urinary tract infections. J. Vet. Internal Med. Accepted.
  2. Jacob, M. E.*, J. Bai, D. G. Renter, A. T. Rogers, X. Shi, and T. G. Nagaraja. 2014. Comparing real-time and conventional PCR to culture-based methods for detecting and quantifying Escherichia coli O157 in cattle feces. J. Food Prot. 77:314-319
  3. Jacob, M. E.*, D. M. Foster, A. T. Rogers, C. C. Balcomb, and M. W. Sanderson.  2013.  Prevalence and relatedness of E. coli O157:H7 in the feces and on the hides and carcasses of U. S. meat goats at slaughter.  Appl. Environ. Microbiol.  79:4154-4158.
  4. Jacob, M. E.*, D. M. Foster, A. T. Rogers, C. C. Balcomb, X. Shi, and T. G. Nagaraja.  2013.  Evidence of non-O157 Shiga toxin-producing Escherichia coli in the feces of meat goats at a U.S. slaughter plant.  J. Food Prot.  In press.
  5. Hutchins, R. G., C. S. Bailey, M. E. Jacob, T. L. Harris, M. W. Wood, K. Saker, and S. L. Vaden.  2013.  The effect of an oral probiotic containing Lactobacillus, Bifidobacterium, and Bacillus species on the vaginal microbiota of spayed female dogs.  J. Vet. Internal Med.  In Press.
  6. Jacob, M. E., X. Shi, B. An, T. G. Nagaraja, and J. Bai*.  2012.  Evaluation of a multiplex real-time PCR for the quantification of Escherichia coli O157 in cattle feces.  Foodborne Pathog. Dis.  9:79-85.  
  7. Jacob, M. E. *, K. M. Almes, X. Shi, J. M. Sargeant, and T. G. Nagaraja.  2011.  Escherichia coli O157:H7 genetic diversity in bovine fecal samples.  J. Food Prot.  74:1186-1188
  8. Dodd, C. C., M. W. Sanderson*, M. E. Jacob, and D. G. Renter.  2011.  Modeling preharvest and harvest interventions for Escherichia coli O157 contamination of beef cattle carcasses.  J. Food Prot.  74:1422-1366
  9. Jacob, M. E., D. G. Renter, Z. D. Paddock, K. F. Lechtenberg, and T. G. Nagaraja*.  2010.  Feeding dried or wet distiller’s grains at various inclusion levels to feedlot cattle affects the fecal prevalence of Escherichia coli O157:H7.  Appl. Environ. Microbiol.  76:7238-7242.    
  10. R. G. Amachawadi., N. W. Shelton, M. E. Jacob, X. Shi, S. K. Narayanan, L. Zurek, S. S. Dritz, J. L. Nelssen, M. D. Tokach, and T. G. Nagaraja. 2010. Occurrence of tcrB, a transferable copper resistance gene, in fecal enterococci of swine. Foodborne Pathog Dis.  7:1089-1097.
  11. Jacob, M.E., D. G. Renter, and T. G. Nagaraja.  2010.  Animal- and truckload-level associations among E. coli O157:H7 in feces and hides at harvest and contamination of pre-intervention beef carcasses.  J. Food Prot.  73:1030-1037.
  12. Jacob, M. E., J. T. Fox, T. G. Nagaraja, J. S. Drouillard, R. Amachawadi, and S. K. Narayanan.  2010.  Effects of feeding elevated concentrations of copper and zinc on the antimicrobial susceptibilities of fecal bacteria in feedlot cattle.  Foodborne Pathog. Dis.  6:643:648.
  13. Jacob, M. E., J. T. Fox, J. S. Drouillard, D. G. Renter, and T. G. Nagaraja.  2009.  Evaluation of feeding dried distiller’s grains with solubles and dry-rolled corn on the fecal prevalence of Escherichia coli O157:H7 and Salmonella spp. in cattle.  Foodborne Pathog Dis.  2:145-153.
  14. Jacob, M. E., T. R. Callaway, and T. G. Nagaraja.  2009.  Dietary interactions and interventions affecting Escherichia coli O157 colonization and shedding in cattle.  Foodborne Pathog Dis.  6:785-792.
  15. Jacob, M. E., J. T. Fox, J. S. Drouillard, D. G. Renter, and T. G. Nagaraja. 2008. Effects of dried distillers’ grain on fecal prevalence and growth of Escherichia coli O157 in batch culture fermentations from cattle.  Appl. Environ. Microbiol., 74(1):38-43. 
  16. Jacob, M. E., G. L. Parsons, M. K. Shelor, J. T. Fox, J. S. Drouillard, D. U. Thomson, D. G. Renter, and T. G. Nagaraja. 2008. Feeding supplemental dried distiller’s grains increases fecal shedding of Escherichia coli O157 in experimentally inoculated calves.  Zoonoses Publ. Hlth. 55(3):125-132.
  17. Jacob, M. E., J. T. Fox, S. K. Narayanan, J. S. Drouillard, D. G. Renter and T. G. Nagaraja.  2008.  Effects of feeding wet corn distiller’s grains with solubles with or without monensin and tylosin on the prevalence and antimicrobial susceptibilities of fecal food-borne pathogenic and commensal bacteria in feedlot cattle.  J. Anim. Sci. 86(5):1182-1190.
  18. Fox, J. T., S. Reinstein, M. E. Jacob, and T. G. Nagaraja.  2008.  Niche marketing production practices for beef cattle in the United States and prevalence of foodborne pathogens.  Foodborne Pathog Dis. 5:559-569.
  19. Jacob, M. E., J. T. Fox, S. L. Reinstein, and T. G. Nagaraja.  2008.  Antimicrobial susceptibility of foodborne pathogens in organic or natural production systems: an overview.  Foodborne Pathog Dis.  5:721-730.