Adam Moeser, DVM, PhD
Associate Professor of Gastrointestinal Biology and Swine Medicine
2000 B.S. - University of Massachusetts at Amherst (Veterinary and Animal Sciences)
2001 M.S. - North Carolina State University (Animal Nutrition)
2006 Ph.D. - North Carolina State University (Gastrointestinal Physiology)
2008 D.V.M. - North Carolina State University
Post Doc - University of North Carolina–Chapel Hill, School of Medicine (Gastrointestinal Biology), National Institutes of Health (NIH) T32 Post Doctoral Fellowship
- PHY/CBS 764 - Advanced Gastrointestinal Pathophysiology
- VMP 916 - Preventive Herd Health and Management I
- VMP 934 –Infection and Immunity
- VMP 936 - Preventive Herd Health and Management II : Swine nutrition and physical exam
- VMP 964 - Swine Medicine (Course coordinator, 3rd year DVM program)
- VMP 984 - Swine Health & Production I (4th year DVM program clinical rotations)
- CBS 770 – Cell Biology
- ANS 330 – Introduction to laboratory Medicine
- Gastrointestinal diseases
- Nutrition-disease interactions
Stress, Gastrointestinal Biology. Stress is an important trigger in the onset and exacerbation of gastrointestinal (GI) diseases of humans and animals. Despite the well-accepted role of stress in GI disease susceptibility, the underlying pathogenic mechanisms remain poorly understood and thus no definitive curative therapies are available. The long-term goal of my research program is to gain a fundamental understanding of the biological mechanisms by which stress impacts the development and clinical severity of important GI diseases. Specifically, our research is focused on the cellular interactions between stress neuropeptides (Corticotropin releasing factor and the urocortin family) and intestinal mast cells, which is a key signaling axis in the intestinal stress response. We believe that this work could have important implications in the understanding of stress-related gut disorders such as allergy/anaphylaxis, Inflammatory Bowel Disease, and Irritable Bowel Syndrome, and may facilitate the design of novel preventative and treatment strategies for veterinary and human patients suffering from these disorders.
- National Institutes of Health (NIH): R01 NICHD HD072968, R03 NIDDK DK097462, K08 NIDDK DK084313
- National Pork Board
- North Carolina Pork Council
- APC, Inc.
- Pfizer Animal Health (Zoetis, Inc)
- Lucta, Inc.
- Oxthera, Inc.
Current Lab members
- Saravanan Ayyadurai PhD, Post-doctoral researcher
- Daljinder Banghoo, undergraduate research scholar, Human Biology (COS)
- Susan D’Costa PhD, Research Associate
- Laura Edwards AS RLATG, Lab Manager/Research technician
- Chelsea Frandsen, undergraduate research assistant, Animal Science (CALS)
- Amelia Gibson MS, PhD candidate CBS Program
- Chelsea Landon PhD, DVM Class of 2017
- Liz Lennon DVM DACVIM, PhD student, NIH T32 Clinician Investigator Program
- Emily Mackey, Combined DVM/PhD program CBS Program
- Matt Milloway, DVM class of 2016
- Julia Medland, MS student CBS Program
- Laura Sommerville PhD, Post-doctoral researcher
- Jenessa Winston DVM, PhD student, NIH T32 Clinician Investigator Program
Honors and Awards
2012 Recipient of the Research Recognition Award by the American Physiological Society (APS) Gastrointestinal Liver Physiology Section.
2011 Recipient of the Bayer Faculty Award for outstanding teaching
2010 Recipient of the Bayer Faculty Award for outstanding teaching
2009 Recipient of the American Gastroenterology Association (AGA) Foundation Elsevier Pilot Research Award
Lab Press Releases/News
McLamb BL, Gibson, AJ, Overman, EL, Stahl CH, Moeser AJ. Early Weaning Stress in Pigs Impairs Innate Mucosal Immune Responses to Enterotoxigenic E. coli challenge and Exacerbates Intestinal Injury and Clinical Disease. 2013 PLoS One. 8:e59838
Onyiah JC, Sheikh SZ, Maharshak N, Steinbach EC, Russo SM, Kobayashi T, Mackey LC, Hansen JJ, Moeser AJ, Rawls JF, Borst LB, Otterbein LE, Plevy SE. Carbon Monoxide and Heme Oxygenase-1 Prevent Intestinal Inflammation in Mice by Promoting Bacterial Clearance. 2013 Gastroenterology, 144(4):789-98.
Stoeker LL, Overman EL, Nordone SK, Moeser AJ, Simões RD, Dean GA. Infection with feline immunodeficiency virus alters intestinal epithelial transport and mucosal immune responses to probiotics. Vet Immunol Immunopathol. 2013. 153:146-52.
Cabrera RA, Xi L, Campbell JM, Moeser AJ, Odle J. Influence of birth order, birth weight, colostrum and serum immunoglobulin G on neonatal piglet survival. 2013 Journal of Animal Science and Biotechnology, 3(1):42.
Karhausen, J, Ma Q, Gibson AJ, Moeser AJ, Griefingholt H, Hale LP, Abraham SN and Mackensen GB. Intestinal mast cells mediate gut injury and systemic inflammation in a rat model of deep hypothermic circulatory arrest. 2013 Critical Care Medicine. In Press
Cabrera RC, Xi l, Ashwell M, Moeser AJ, Odle J. Early post-natal kinetics of colostral IgG absorption in fed and fasted piglets and developmental expression of the intestinal IgG receptor. J. Anim. Sci. 91:211-8.
Lennon EM, Maharshak N, Borst LB, Plevy SE, Moeser AJ. Early Life Stress Triggers Persistent Colonic Barrier Dysfunction and Exacerbates Colitis in Adult IL-10-/- Mice. Inflammatory Bowel Diseases 2013, 19:712-719.
Overman EL, Rivier JER, and Moeser AJ. CRF Induces Intestinal Epithelial Barrier Injury via the Release of Mast Cell Proteases and TNFα. 2012. PLoS One. 7(6):e39935
Jacobi SK, Moeser AJ, Corl BA, Harrell RJ, Blikslager AT, Odle J. Dietary Long-Chain PUFA Enhance Acute Repair of Ischemic-Injured Intestine of Suckling Pigs. J Nutr. 142(7):1266-71, 2012.
Nighot M, Ueno R, Moeser AJ, Blikslager AT. Gastro-protective properties of the novel prostone SPI-0811 in acid-injured porcine gastric mucosa. World J. Gastroenterol. 2012 In press
Moeser AJ, Overman EL, Pittman JS. Defects in Small Intestinal Epithelial Barrier Function and Morphology Associated with Peri-Weaning Failure to Thrive Syndrome (PFTS) in Swine. Res Vet Sci. 2012 93(2):975-82.
T. Shan, L. Li, P. Simmonds, C. Wang, A . Moeser, and E. Delwart. The fecal virome of pigs on a high-density farm. J Virol. 85(22):11607-708, 2011.
Peace RM, Campbell J, Crenshaw JD, Polo J, Moeser AJ. Spray-dried porcine plasma influences intestinal barrier function, inflammation, and diarrhea in weaned pigs. J Nutr. 141(7):1312-7, 2011.
Nighot PK, Moeser A, Ali RA, Blikslager AT, Koci MD. Astrovirus infection induces sodium malabsorption and redistributes sodium hydrogen exchanger expression. Virology. 401:146-54, 2010.
Smith F, Clark JE, Overman EL, Tozel CC, Huang JH, Rivier JF, Blikslager AT, Moeser AJ. Early weaning impairs postweaning development of intestinal barrier function in porcine jejunum. Am J Physiol Gastrointest Liver Physiol. 298(3):G352-63, 2010.
Hansen SL, Trakooljul N, Liu HC, Moeser AJ, Spears JW. High dietary iron reduces transporters involved in iron and manganese metabolism and increases intestinal permeability in calves. J Dairy Sci. 93(2):656-65, 2010.
Hansen SL, Trakooljul N, Liu HC, Moeser AJ, Spears JW. Iron transporters are differentially regulated by dietary iron, and modifications are associated with changes in manganese metabolism in young pigs. J Nutr. 139(8):1474-96, 2009.
Nighot PK, Moeser AJ, Ryan KA, Ghashghaei T, Blikslager AT. ClC-2 is required for rapid restoration of epithelial tight junction in ischemic-injured murine jejunum. Exp Cell Res. 315;110-118, 2009.
Moeser AJ, Nighot PK, Roerig B, Ueno R, Blikslager AT. Comparison of the chloride channel activator lubiprostone and the oral laxative Polyethylene Glycol 3350 on mucosal barrier repair in ischemic-injured porcine ileum. World J Gastroenterol. 14:6012-7, 2008.
Moeser AJ, Nighot PK, Ryan KA, Simpson JE, Clarke LL, Blikslager AT.Mice lacking the Na+/H+ exchanger 2 have impaired recovery of intestinal barrier function. Am J Physiol Gastrointest Liver Physiol. 295:G791-7, 2008.
Corl BA, Odle J, Niu X, Moeser AJ, Gatlin LA, Phillips OT, Blikslager AT, Rhoads JM. Arginine activates intestinal p70(S6k) and protein synthesis in piglet rotavirus enteritis. J Nutr. 138:24-9, 2008.
Moeser AJ, Blikslager AT, Swanson C. Minimum alveolar concentrations of Sevoflurance in domestic swine. Res Vet Sci. 84:283-5, 2008.
Moeser AJ, Ryan KA, Knighot PK, Blikslager AT. Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigs. Am J Physiol Gastrointest Liver Physiol. 293:G413-21, 2007.
Moeser AJ and Blikslager AT. Mechanisms of porcine diarrheal disease. J Am Vet Med Assoc. 231:56-67, 2007.
Little D, Brown SA, Campbell NB, Moeser AJ, Davis JL, and Blikslager AT. The Effects of the cyclooxygenase inhibitors meloxicam and flunixin meglumine on recovery of ischemic-injured equine jejunum. Am J Vet Res. 68:614-24, 2007.
van Kempen TATG, Moeser AJ, Sewalt N, van Heughten. Nutrient Utilization of processed corn by-products for use in swine nutrition. J Anim Sci. 85:1695-701, 2007.
Blikslager AT, Moeser AJ, Gookin JL, Jones SL, and Odle J. Mechanisms of intestinal repair in the injured intestine. Physiol Rev. 87:545-64, 2007.
Moeser AJ, vander Klok C, Ryan KA, Wooten JG, Little D, Cook VL, Blikslager AT. Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig. Am J Physiol Gastrointest Liver Physiol. 292:G173-181, 2007.
Rhoads JM, Corl B, Harrell R, Niu X, Gatlin L, Phillips O, Moeser AJ, Wu G, Odle J. Intestinal ribosomal p70s6k signaling is increased in piglet rotavirus enteritis. Am J Physiol Gastrointest Liver Physiol. 292:G913-22, 2007.
Moeser AJ, Nighot PK, Engelke K, Ueno R, and Blikslager AT. Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, Lubiprostone. Am J Physiol Gastrointest Liver Physiol. 292:G647-656, 2007.
van Kempen TA, van Heughten E, Moeser AJ, Muley NS, Sewalt VJ. Selecting soybean meal characteristics preferred for swine nutrition. J Anim Sci. 84:1387-95, 2006.
Moeser AJ, Nighot PK, Ryan KA, Wooten JG, Blikslager AT. Prostaglandin-mediated inhibition of the Na+/H+ exchanger isoform 2 stimulates recovery of barrier function in ischemia-injured intestine. Am J Physiol Gastrointest Liver Physiol. 291:G885-G894, 2006.
Moeser AJ, Haskell MH, Shifflett DE, Little D, Schultz BD, Blikslager AT. ClC-2 chloride secretion mediates prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum. Gastroenterology.127:802-815, 2004.