Adam Moeser MS, PhD, DVM
Assistant Professor, Pig Health & Production
Doctor of Veterinary Medicine, 2008,
North Carolina State University
PhD in Gastrointestinal Physiology, 2006,
North Carolina State University
MS in Swine Nutrition, 2001, North Carolina State University
Enhance veterinary and human medicine through research and teaching.
Pathophysiology and treatment of enteric disorders of food animal species with emphasis in swine.
Gastrointestinal Physiology. The objective of this laboratory is to study basic mechanisms of stress-induced intestinal dysfunction. Stress is an important contributing factor to enteric disorders of veterinary species and humans however, the mechanisms are poorly understood. To date, our work has focused on the role of mucosal mast cells in psychological stress-induced disturbances in intestinal mucosal barrier function. We believe that this work will have important implications in the understanding of stress-related gut disorders such as infectious diarrhea, Inflammatory Bowel Disease, and Irritable Bowel Syndrome, and will facilitate the design of novel preventative and treatment strategies for veterinary and human patients suffering from these disorders.
- VMP 916 - Preventive Herd Health and Management I (Spring Semester)
- VMP 936 - Preventive Herd Health and Management II (Fall Semester)
- VMP 964 - Swine Medicine (3rd year DVM program)
- VMP 984 - Swine Health & Production I (4th year DVM program clinical rotations)
- PHY/CBS 764 - Advances in Gastrointestinal Pathophysiology
Corl BA, Odle J, Niu X, Moeser AJ, Gatlin LA, Phillips OT, Blikslager AT, Rhoads JM. Arginine activates intestinal p70(S6k) and protein synthesis in piglet rotavirus enteritis. J Nutr. 138:24-9, 2008,
Moeser AJ, Blikslager AT, Swanson C. Minimum alveolar concentrations of Sevoflurance in domestic swine. Res Vet Sci. 84(2):283-5, 2008.
Moeser AJ, Ryan KA, Knighot PK, Blikslager AT. Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigs. Am J Physiol Gastrointest Liver Physiol. 293:G413-21, 2007.
Moeser AJ and Blikslager AT. Mechanisms of Porcine Diarrheal Disease. JAVMA 231:56-67, 2007.
Little D, Brown SA, Campbell NB, Moeser AJ, Davis JL, and Blikslager AT. The Effects of the Cyclooxygenase Inhibitors Meloxicam and Flunixin Meglumine on Recovery of Ischemic-Injured Equine Jejunum. Am J Vet Res. 68:614-24, 2007.
van Kempen TATG, Moeser AJ, Sewalt N, van Heughten. Nutrient Utilization of processed corn by-products for use in swine nutrition. J Anim Sci. 85:1695-701, 2007.
Blikslager AT, Moeser AJ, Gookin JL, Jones SL, and Odle J. Mechanisms of intestinal repair in the injured intestine. Physiol Rev. 87:545-64, 2007.
Moeser AJ, vander Klok C, Ryan KA, Wooten JG, Little D, Cook VL, Blikslager AT. Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig. Am J Physiol Gastrointest Liver Physiol. 292:G173-181, 2007
Rhoads JM, Corl B, Harrell R, Niu X, Gatlin L, Phillips O, Moeser AJ, Wu G, Odle J. Intestinal Ribosomal p70s6k Signaling is Increased in Piglet Rotavirus Enteritis. Am J Physiol Gastrointest Liver Physiol. 292:G913-22, 2007.
Moeser AJ, Nighot PK, Engelke K, Ueno R, and Blikslager AT. Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, Lubiprostone. Am J Physiol Gastrointest Liver Physiol. 292:G647-656, 2007
van Kempen TA, van Heughten E, Moeser AJ, Muley NS, Sewalt VJ. Selecting soybean meal characteristics preferred for swine nutrition. J Anim Sci 84:1387-95, 2006
Moeser AJ, Nighot PK, Ryan KA, Wooten JG, Blikslager AT. Prostaglandin-Mediated Inhibition of the Na+/H+ Exchanger Isoform 2 Stimulates Recovery of Barrier Function in Ischemia-Injured Intestine. Am J Physiol Gastrointest Liver Physiol. 291:G885-G894, 2006
Moeser AJ, Haskell MH, Shifflett DE, Little D, Schultz BD, Blikslager AT. ClC-2 chloride secretion mediates prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum. Gastroenterology. 127:802-815, 2004
Shifflett DE, Bottone Jr FG, Young KM, Moeser AJ, Jones SL, Blikslager AT. Neutrophils augment recovery of porcine ischemia-injured ileal mucosa by an IL-1β and COX-2 dependent mechanism. Am J Physiol Gastrointest Liver Physiol. 287:G50-57, 2004.
Shifflett DE, Jones SL, Moeser AJ, Blikslager AT. Mitogen activated protein kinases regulate COX-2 and mucosal recovery in ischemic-injured porcine ileum. Am J Physiol Gastrointest Liver Physiol. 286:G906-13, 2004.
Moeser, AJ, M. T. See, E. van Heugten, W. E. M. Morrow, and T. A. T. G. van Kempen. Diet and evaluators affect perception of swine waste odor: An educational demonstration. J. Anim Sci. 81: 3211-3215, 2003.
Moeser, AJ, I.B. Kim, E. van Heugten and T.A.T.G. van Kempen. Nutritional value of degermed, dehulled corn for pigs and its impact on the gastrointestinal tract and nutrient excretion. J. Anim. Sci. 80: 2629-2638, 2002
Moeser, AJ and T. van Kempen. Dietary fiber level and enzyme inclusion affect nutrient digestibility, excreta pH, and fecal production in grower pigs. J Sci Food Agric 82: 1606-1613, 2002
Mroz, Z., AJ Moeser, A.W. Jongbloed, Karl Vreman, J. Th.M. van Diepen and T.T. Canh. Effects of dietary carbohydrates and buffering capacity on nutrient digestibility and manure characteristics in finishing pigs. J Anim Sci. 78:3096-3106, 2000