Luke B. Borst, DVM, PhD, DACVP
Veterinary Anatomic Pathology
Office: #446, CVM Research Building
Phone: (919) 513-8287
- 2009, PhD, University of Illinois, Veterinary Pathology
- 2008, DACVP, University of Illinois, Anatomic Pathology Residency
- 2005, DVM, University of Illinois, Veterinary Sciences
- 2009-Present, Assistant Professor, Department of Population Health and Pathobiolog, College of Veterinary Medicine North Carolina State University
- 2008- 2009, Visiting Clinical Assistant Professor, Department of Pathobiology, College of Veterinary Medicine University of Illinois, Urbana, IL
- 2005-2008, Teaching Associate and Residency in Anatomic Veterinary Pathology, University of Illinois, Urbana, IL Completed with ACVP board certification September 2008
- 2002-2005, Laboratory Technician in Diagnostic and Molecular Microbiology, Veterinary Diagnostic Laboratory, University of Illinois at Urbana-Champaign
- Streptococcal pathogenesis
- Cancer metabolism
- Equine strangles: Using a zebrafish model of streptococcal pathogenesis we have evaluated several gene deletion mutants of Streptoccus equi ssp equi for attenuation. Continuing work revolves around the identification of novel virulence mechanisms which may be disrupted and then screened for attenuation first in zebrafish and mice before evaluation in horses. The goal of this project is a rationally designed, safe and effective modified live vaccine that is readily identifiable if recovered from vaccinated animals.
- Streptococcus equi ssp zooepidemicus: A novel bacteriocin that is bacteriocidal to Streptoccus equi ssp equi has been identified. Characterization of this small compound is the goal of future studies.
- Enterococcus cecorum: Spinal abscesses causing significant morbidity in chickens due to E. cecorum have been documented. We are working with industry partners to develop detection methods for this organism while investigating the genetic basis for virulence in collected strains.
- Cancer metabolism: The molecular pathogenesis of neoplasia remains largely unknown. Targeting canine osteosarcoma we are studying alterations in metabolic phenotypes which may allow for the detection underlying genetic lesions.
- Borst LB*, Suyemoto MM, Robbins KM, Lyman RL, Martin MP and Barnes HJ. Molecular epidemiology of Enterococcus cecorum isolates recovered from enterococcal spondylitis outbreaks in the southeastern United States. Avian Pathol 41: 479-485, 2012
- Robbins KM, Suyemoto MM, Lyman RL, Martin MP, Barnes HJ, and Borst LB*. An Outbreak of Enterococcal Spondylitis in Broilers Caused by Enterococcus cecorum. Avian Diseases 12/2012 56(4):768-73.
- Lanka S, Borst LB, Patterson SK, Maddox CW A multiphasic typing approach to subtype Streptococcus equi subspecies equi. J Vet Diagn Invest. 2010;22 928-936.
- Hillman L, Garrett L, Borst L and Fan T Investigation of the biologic behavior and CCR7 immunohistochemical staining of canine oral and perioral mast cell tumors: 44 cases (1996-2006) –accepted JAVMA
- Borst LB, Maddox CW, Ridgway M; Evaluation of a quantative real-time PCR for the detection of canine leptospirosis – in revision JVDI
- Lowe A, Barger AM, Graves T, Borst LB; Clinical, clinicopathological and selected histopathological changes due to glucocorticoid use in cats. Veterinary Record, 162:777-783, 2008
- Krug W, Manfra-Marretta S, de Lorimier LP, White DK, Borst LB; Diagnosis and management of Wegener’s granulomatosis is a dog. J.Vet.Dent. 23(4):231-236, 2006