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John Cullen, VMD, PhD

John Cullen

Anatomic Pathology

Adjunct Senior Researcher, Hamner Institute
Associate, Toxicology Faculty

Office: D-339, CVM Main Building

Course Involvement

  • VMP 931: General Pathology
  • VMP 941: Systemic Pathology
  • VMP 991D: Necropsy Pathology Selective
  • VMP 977: Clinical Laboratory/Necropsy
  • VMP 991M: Surgical Pathology Selective
  • VMM 991K: Selective in Nondomestic Animal Pathology
  • CBS 804: Seminar in Necropsy Pathology
  • CBS 803: Seminar in Surgical Pathology
  • CBS 810F: Pathology Concentration Seminar

Graduate Courses

  • CBS 565: Fundamentals of Biomedical Sciences


Research Area

Current Research

Current Collaborators

Selected Publications

2014  John M. Cullen, Cynthia J. Willson, Jonathan D. Minch, Carie L. Kimbrough, Katrina L. Mealey,  Lack of association of ABCB4 insertion mutation with gallbladder mucoceles in dogs. J Vet Diag Invest (In Press)

2014 Alison H. Harrill, John S. Eaddy, Kelly Rose, John M. Cullen, Lakshmi Ramanathan, Stephen Wanaski, Stephen Collins, Yu Ho, Paul B. Watkins, Edward L. LeCluyse,   Mechanistic Interpretation of Elevated Liver Biomarkers in Beagle Dogs Treated with GABAA Receptor Antagonist NP260 in the Absence of Histopathological Correlate. Tox App Pharm (In Press)

2014  Spruiell K, Richardson RM, Cullen JM, Awumey EM, Gonzalez FJ, Gyamfi MA,  Role of pregnane X receptor in obesity and glucose homeostasis in male mice.. J Biol Chem. 289:3244-61. 289(6):3244-61

2013  Kavanagh K, Wylie AT, Tucker KL, Hamp TJ, Gharaibeh RZ, Fodor AA, Cullen JM. Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates. Am J Clin Nutr. 2013 98:349-57.

2013 Hailey JR, Nold JB, Brown RH, Cullen JM, Holder JC, Jordan HL, Ennulat D, Miller RT. Biliary Proliferative Lesions in the Sprague-Dawley Rat: Adverse/Non-adverse. Toxicol Pathol. Aug 19. [Epub ahead of print]

2013  Cianciolo R., Yoon L., Krull D., Stokes A., Jordan H., Rodriguez A., Davis C., Falls J., Cullen J., Kimbrough C., Berridge B. Gene Expression Analysis and Urinary Biomarker Assays Reveal Activation of Tubulointerstitial Injury Pathways in a Rodent Model of Chronic Proteinuria (Doxorubicin Nephropathy), Nephron Experimental 124:1-10.

2013 Kapoor A, Simmonds P, Cullen JM, Scheel T, Medina JL, Giannitti F, Nishiuchi E, Brock KV, Burbelo PD, Rice CM, Lipkin WI. Identification of a pegivirus (GBV-like virus) that infects horses. J Virol. 87:185-90.

2013 Kapoor A, Simmonds P, Scheel TK, Hjelle B, Cullen JM, Burbelo PD, Chauhan LV, Duraisamy R, Sanchez Leon M, Jain K, Vandegrift KJ, Calisher CH, Rice CM, Lipkin WI.Identification of rodent homologs of hepatitis C virus and pegiviruses. MBio. Apr 9;4(2). E00216-

2013 Piper A, Ribeiro M, Smith KM, Briggs CM, Huitt E, Nanda K, Spears CJ, Quiles M, Cullen J, Thomas ME, Brown DT, Hernandez R. Chikungunya Virus Host-Range E2-Transmembrane Deletion Mutants Induce Protective Immunity Against Challenge in C57BL/6J Mice. J Virol. Apr 3. [Epub ahead of print]

2013 Kane AM, Defrancesco TC, Boyle MC, Malarkey DE, Ritchey JW, Atkins CE, Cullen JM, Kornegay JN, Keene BW. Cardiac structure and function in female carriers of a canine model of Duchenne muscular dystrophy. Res Vet Sci. Jun;94(3):610-7.

2013  Harrington JT, McMullen RJ Jr, Cullen JM, Campbell NB, Gilger BC. Diode laser endoscopic cyclophotocoagulation in the normal equine eye. Vet Ophthalmol.16:97-110.

2012 Hutchins RG, Breitschwerdt EB, Cullen JM, Bissett SA, Gookin JL.Limited yield of diagnoses of intrahepatic infectious causes of canine granulomatous hepatitis from archival liver tissue. J Vet Diagn Invest. Sep;24(5):888-94

2012  Harrington JT, McMullen RJ Jr, Cullen JM, Gilger BC Evaluation of diode endoscopic cyclophotocoagulation in bovine cadaver eyes. Am J Vet Res. 73:1445-52.

2012  Minter LJ, Cullen JM, Loomis MR. Reye's or Reye's-like syndrome in western lowland gorilla (Gorilla gorilla gorilla).J Med Primatol. 41:329-31.

2012 Pate DO, Clode AB, Olivry T, Cullen JM, Salmon JH, Gilger BC. Immunohistochemical and immunopathologic characterization of superficial stromal immune-mediated keratitis in horses. Am J Vet Res.;73:1067-73.

2012  Burbelo PD, Dubovi EJ, Simmonds P, Medina JL, Henriquez JA, Mishra N, Wagner J, Tokarz R, Cullen JM, Iadarola MJ, Rice CM, Lipkin WI, Kapoor A. Serology-enabled discovery of genetically diverse hepaciviruses in a new host. J Virol. 86:6171-8.

2012 Cullen JM, Faiola B, Melich DH, Peterson RA, Jordan HL, Kimbrough CL, Prescott JS, Miller RT. Effects of Kupffer Cell Depletion on Acute Alpha-Napthylisothiocyanate-induced Liver Toxicity in Male Mice. Toxicol Pathol. Aug 10.

 2012 Minter LJ, Cullen JM, Loomis MR. Reye's or Reye's-like syndrome in western lowland gorilla (Gorilla gorilla gorilla). J Med Primatol. 41:329-31.

2012 Hutchins RG, Breitschwerdt EB, Cullen JM, Bissett SA, Gookin JL. Limited yield of diagnoses of intrahepatic infectious causes of canine granulomatous hepatitis from archival liver tissue.  J Vet Diagn Invest.;24:888-94

2012 Burbelo PD, Dubovi EJ, Simmonds P, Medina JL, Henriquez JA, Mishra N, Wagner J, Tokarz R, Cullen JM, Iadarola MJ, Rice CM, Lipkin WI, Kapoor A. Serology-enabled discovery of genetically diverse hepaciviruses in a new host. J Virol.;86:6171-8.

2011 Burke CT, Cullen JM, State A, Gadi S, Wilber K, Rosenthal M, Bulysheva A, Pease A, Mauro MA, Fuchs H. Development of an animal model for radiofrequency ablation of primary, virally induced hepatocellular carcinoma in the woodchuck. J Vasc Interv Radiol. 22:1613-1618

2011 Hedan B, Thomas R, Motsinger-Reif A, Abadie J, Andre C, Cullen J, Breen M. Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior. BMC Cancer. 26;11:201.

2011 Cullen JM, Williams C, Zadrozny L, Otstot JT, Solomon GG, Sills RC, Hong HH. H-ras consensus sequence and mutations in primary hepatocellular carcinomas of lemurs and lorises. Vet Pathol. 48:868-74.

2010 Faiola B, Peterson R, Jordan, H, Kimbrough CA, Cullen JM. Acute ANIT Toxicity in Male IL-10 Knockout and Wild Type Mice. Tox Pathol (In press)

2010 Cullen J M, Falls J G, Brown HR, Yoon LW, Cariello N F, Faiola B, Kimbrough C L, Jordan HL, Miller R T. Time Course Gene Expression using Laser Capture Microscopy-extracted Bile Ducts, But Not Hepatic Parenchyma, Reveals Acute Alpha-Napthylisothiocyante Toxicity. Tox Pathol (In press)

2010 Zadrozny LM, Williams CV, Remick AK, Cullen JM Spontaneous Hepatocellular Carcinoma in Captive Prosimians..Vet Pathol. 2010 Feb

2010 Brown DL, Van Winkle T, Cecere T, Rushton S, Brachelente C, Cullen JM. Congenital hepatic fibrosis in 5 dogs. Vet Pathol. 47:102-7.

2009 Cullen JM. Summary of the world small animal veterinary association standardization committee guide to classification of liver disease in dogs and cats. Vet Clin North Am Small Anim Pract. 39:395-418

2009 Cullen JM, Brown DL, Kissling GE, Foley JF, Rizzo J, Marion PL, Parron VI, French JE.Aflatoxin B1 and/or hepatitis B virus induced tumor spectrum in a genetically engineered hepatitis B virus expression and Trp53 haploinsufficient mouse model system for hepatocarcinogenesis.Toxicol Pathol.37:333-42.

2008 Cullen JM, Lindsey-Pegram D, Cote PJ. Serologic survey of woodchuck hepatitis virus in North Carolina woodchucks (Marmota monax).J Zoo Wildl Med. 39:263-5

2008 Ranck RS, Cullen JM, Waggie KS, Marion PL  Harderian gland neoplasms in captive, wild-caught Beechey ground squirrels (Spermophilus beecheyi). Vet Pathol. 45:388-92

2008 Macias E, de Marval PL, Senderowicz A, Cullen J, Rodriguez-Puebla ML.Expression of CDK4 or CDK2 in mouse oral cavity is retained in adult pituitary with distinct effects on tumorigenesis. Cancer Res. 68:162-71

2007 Brown DL, Anderson M, Cullen JM,  Mesenchymal hamartoma of the liver in a late-term equine fetus..Vet Pathol. 44:100-2.

2007 Hess PR, Barnes C, Woolard MD, Johnson MD, Cullen JM, Collins EJ, Frelinger JA.Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin. Blood.  15:3300-7

2006 Johnson AL, Divers TJ, Freckleton ML, McKenzie HC, Mitchell E, Cullen JM, McDonough SP.Fall panicum (Panicum dichotomiflorum) hepatotoxicosis in horses and sheep. J Vet Intern Med. 20:1414-21

2006 Cullen J M    Miller R T, The role of pathology in the identification of drug-induced hepatic toxicity. Expert Opinion on Drug Metabolism & Toxicology , Vol. 2, No. 2, Pgs 241-247
2005 Cullen JM. Mechanistic classification of liver injury. Toxicol Pathol. 33: 6-8.

2005 Hajjou M, Norel R, Carver R, Marion P, Cullen J, Rogler LE, Rogler CE. cDNA microarray analysis of HBV transgenic mouse liver identifies genes in lipid biosynthetic and growth control pathways affected by HBV. J, Med Virol. 77: 57-65.

2005 Elmore SA, Basseches J, Anhalt GJ, Cullen JM, Olivry T. Paraneoplastic pemphigus in a dog with splenic sarcoma. Vet Pathol. 42: 88-91.

2004 Zhu Y, Cullen JM, Aldrich CE, Saputelli J, Miller D, Seeger C, Mason WS, Jilbert AR. Adenovirus-based gene therapy during clevudine treatment of woodchucks chronically infected with woodchuck hepatitis virus. Virol. 327:26-40.

2004 Li DH, Kumanogoh A, Cao TM, Parnes JR, Cullen JM. Woodchuck interleukine-6 gene: structure, characterization, and biologic activity. Gene. 342: 157-164.

2001 Cullen JM, Li DH, Brown C, Eisenberg GC, Wolfe KC, Toole J, Gibbs C Antiviral Efficacy and Pharmacokinetics of Oral Adefovir Dipivoxil in Chronically WHV-infected Woodchucks. Antimicrob Agents Chemother. 45:2740-5

2001 Zhu, Y., Yamamoto, T., Cullen, J., Saputelli, J., Aldrich C.E., Miller, D.S., Litwin, S., Furman, P.A., Jilbert, A.R., Mason, W.S. Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis. J Virol, 75:311-322.

2001 Hervas-Stubbs S, Lasarte JJ, Sarobe P, Vivas I, Condreay L, Cullen JM, Prieto J,Borras-Cuesta F. T-helper cell response to woodchuck hepatitis virus antigens after therapeutic vaccination of chronically-infected animals treated with lamivudine. J Hepatol. 35:105-11.

2001 Bunch SE, Johnson SE, Cullen JM. Idiopathic noncirrhotic portal hypertension in dogs: 33 cases (1982-1998). J Am Vet Med Assoc, 218:392-9.

2000 Ohashi, K, Marion, P.L., Nakai, H., Meuse, L., Cullen, J.M., Bordier, B.B., Schwall, R., Greenberg, H.B., Glenn, J.S., Kay, M.A., Sustained survival of human hepatocytes in mice: A model for in vivo infection with human hepatitis B and hepatitis D viruses. Nature Med, 6:327-333. 2000 Li, D.H.,Brown, C., Havel.E., Cullen, J.M., Woodchuck lymphotoxin alpha, beta and tumor necrosis factor genes; Structure, characterization and biological activity. Gene,242:295-305.