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Bruce Hammerberg, DVM, PhD

Bruce Hammerberg


Office: 210, CMV Research Building
Phone: 919-513-7712
Fax: 919-515-4237

Course Involvement

Graduate Courses

Undergraduate Courses


Research Area

IgE-dependent allergic diseases and the role of mast cells in allergic diseases and nematode infections.

Current Research

My current research expertise is in allergic diseases and nematode biology. Regarding allergic disease research I have built this on the development of canine x murine heterohybridomas and single chain variable fragment antibodies with specificity for canine IgE and its associated proteins. In addition, I am planning to use this same approach to develop reagents for diagnosis and treatment of allergic disease in horses.

Current Collaborators

Thierry Olivry in the Center for Comparative Medicine and Translational Research, Core of Allergy and Clinical Immunology.

Future Research

Development of therapeutic monoclonal antibodies for the treatment of canine, feline and equine allergic diseases. Generation of diagnostic tests based on monoclonal antibodies specific for IgE and the multiple proteins interacting with IgE.

Selected Publications

SSeals, SL, Kearney, M, Del Piero, F, Hammerberg, B, Pucheu-Haston, CM. 2014. A study for characterization of IgE-
mediated cutaneous immediate and late-phase reactions in non-allergic domestic cats. Vet. Immunol. Immunopathol. (in press) on line

Pucheu-Haston, C, Kasparek, K, Stout, R, Kearney, M, Hammerberg, B. 2014. Effects of pentoxifylline on immediate and late-phase cutaneous reactions in response to anti-immunoglobulin E antibodies in clinically normal dogs. Am. J. Vet. Res. 75: 152-160

Bexley, J, Nuttall, TJ, Hammerberg, B, Fitzgerald, JR, Halliwell, RE. 2013. Serum anti-Staphylococcus psuedintermedius IgE and IgG antibodies in dogs with atopic dermatitis. Vet. Dermatol. 24: 19-24

Hammerberg, B. 2014. Canine IgE. In: Bruce Hammerberg. Canine IgE. In: Veterinary Allergy. Ed. Ciara Noli, Aiden Foster and Wayne RosenKrantz. Wiley-Blackwell. 2013. In press.

Ricci, R, Hammerberg, B, Paps, J, Contiero, B, Jackson, H. 2010. A comparison of the clinical manifestations of feeding whole and hydrolysed chicken to dogs with hypersensitivity to the native protein. Vet. Dermatol. 21: 358-366.

Hammerberg, B. 2009. Canine Immunoglobulin E (IgE). Vet Immunol Immunopathol 7-12.

Bexley, J, Hogg, JE, Hammerberg, B, Halliwell, REW. 2009. Levels of house dust mite-specific immunoglobulin E (IgE) in different cat populations using a monoclonal based anti-IgE enzyme-linked immunosorbent assay (ELISA). Vet Dermatol 20:562-568.

Pucheu-Haston, CM, Jackson, HA, Olivry, T, Dunston, SM, Hammerberg, B. 2008. Epicutaneous Sensitization with Dermatophagoides farinae Induces Generalized Allergic Dermatitis and Elevated Mite-Specific Immunoglobulin E Levels in a Canine Model of Atopic Dermatitis. Clin Expl Allergy 38:667-679.

Orton, SM, Arasu, P, Hammerberg, B. 2007. A Novel Gene from Brugia sp. that Encodes a Cytotoxic Fatty Acid Binding Protein Allergen Recognized by Canine Monoclonal IgE and Serum IgE from Infected Dogs. J Parasitol 93:1378-1387.

Pucheu-Haston, CM, Shuster, D, Olivry, T, Brianceau, P, Lockwood, P, McClanahan, T, de Waal Malefyt, R, Mattson, JD, Hammerberg, B. 2006. A canine model of cutaneous late-phase reactions: prednisolone inhibition of cellular and cytokine responses. Immunology 117:177-187.

Tater C, Jackson HA, Paps J, Hammerberg B. 2005. Routine prophylactic vaccination enhances an allergen specific serum IgE and IgG response in allergic dogs but this response is not seen with aluminum adjuvant alone. Am J Vet Res 66:1572-1577.

Hammerberg, B. Chapter 4: Canine Immune System. In: Animal Models of Human Inflammatory Skin Diseases. Pp. 79 -90. Ed. Lawrence S. Chan. CRC Press, Boca Raton, Fl. 2004.

Jackson, H.A., Jackson, M.W., Coblentz, L., Hammerberg, B. 2003. Evaluation of the clinical and allergen specific serum IgE response to oral challenge with cornstarch, corn, soy and a soy hydrolysate in dogs with spontaneous food allergy. Vet. Derm. 14:181-187.

Little, D., Flowers, J.R., Hammerberg, B., Gardner, S.Y. 2003. Management of drug-resistant cyathostominosis on a breeding farm in central North Carolina. Equine Veterinary Journal 35:246-251.

Kimber, I., Dearman, R.J., Penninks, A.H., Knippels, L.M.J., Buchanan, R.B., Hammerberg, B., Jackson, H.A. and Helm, R.M. 2003. Assessment of protein allergenicity on the basis of immune reactivity: animal models. Environmental Health Perspectives 111:1125-1130.

Wang, C.Y., Walfield, A.M., Fang, X., Hammerberg, B., Ming, J.Y., Li, L., Shen, M., Alexander, V., MacGlashan, D.W. 2003. Synthetic IgE peptide vaccine for immunotherapy of allergy. Vaccine 21:1580-1590.

Jackson, H. A., Smith, C., Hammerberg, B. 2002. Evaluation of a spontaneous canine model of IgE mediated food hypersensitivity: dynamic changes in serum, faecal and allergen-specific IgE relative to dietary change. Comp. Med. 52:316-321.

Watson BI, Hammerberg B. 2000. Identification of a collectin-llike protein in pig serum that binds a component in perienteric fluid from Ascaris suum. Comp Immunol Microbiol Infect Dis 23:113-124.

Vaden SL, Hammerberg B, Davenport DJ, Orton SM, Trogdon MM, Melgarejo T, Van Camp SD, Williams DA.SD. 2000. Food hypersensitivity reaction in soft coated wheaten terriers with protein-losing enteropathy or protein-losing nephropathy or both: gastroscopic food sensitivity testing, dietary provocation and fecal immunoglobulin E. Journal of Vet Int Med 14:60-67.[8/12/2014 3:51:16 PM]

Ediriwickrema CS, Tonkonogy S, Hammerberg B. 2000. Natural killer cell-dependent immunoglobulin G2a anti-bovine serum albumin (BSA) reponse elicited by high molecular weight dextran-BSA conjugates associated with dextran-
mediated macrophage-NK cell interaction. Immunology. 101: 474-483.

Orton SM, Weinstock D, Hammerberg B. 1998. Association of elevated lymph node cell release of histamine and tumor necrosis factor with genetic predisposition to limb edema formation in dogs infected with Brugia pahangi. Am J Trop Med Hyg. 58:695-704.

Hammerberg B, Bevier D, DeBoer DJ, Olivry T, Orton SM, Gebhard D, Vaden SL. 1997. Auto IgG anti-IgE and IgG x IgE immune complex presence and effects on ELISA-based quantitation of IgE in canine atopic dermatitis, demodectic acariasis and helminthiasis. Vet Immunol Immunopathol 60:33-46.

Schreuer D. and Hammerberg B. Inhibition by platelets of invitro blastogenic responses of canine PBMC by a PAF-
dependent mechanism. Vet. Immunol. and Immunopathol., 52:135-145, 1996

Gebhard D., Orton S., Edmiston D., Nakagaki K., DeBoer D. and Hammerberg B. Canine IgE monoclonal antibody specific for a filarial antigen: production by a canine X murine heterohybridoma using B cells from a clinically affected lymph node. Immunology 85:429-434, 1995

Schreuer D. and Hammerberg B. Modulation of cellular and humoral immunity, and disease manifestation during onset of patency in Brugia pahangi-infected dogs. Immunology 79:658-666, 1993

Miller S., Schreuer D. and Hammerberg B. Inhibition of antigen-driven proliferative responses and enhancement of antibody production during infection with Brugia pahangi. J. Immunol. 147:1007-1013, 1991