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Edward Havell, PhD

textMicrobiology and Immunology
Research Professor

Office: Research Building, Room 452
Lab: 476-A
Phone
: (919) 515.6184
Fax: (919) 513.3044
Email: Ed_Havell@ncsu.edu

Course Involvement

Graduate Courses

Education/Training

Expertise and Research Area

Interferons, cytokines, intracellular bacteria and host antibacterial immunity

Research, Extension and Engagement Activities

Our research centers on:

1.) The generation and characterization of avirulent Listeria monocytogenes mutants for use as orally administered vaccine vectors expressing heterologous pathogenic bacterial or tumor antigens. The goal of this research is to obtain effective and safe noninvasive oral vaccine vectors that can present bacterial and tumor antigens to the host’s gut-associated lymphoid tissue in order to induce protective immunity.

2.) The study of innate and adaptive antilisterial resistance mechanisms expressed at various stages of pregnancy in mice.  The objective of this research is to determine whether the conceptus is capable of altering maternal antilisterial immunity and if so, how and when during gestation.

3.) Investigations into the ability of Listeria monocytogenes to induce the synthesis of cytokines in cultured human and mouse enterocytes and trophoblasts.  These studies enable the characterization of cytokines that function in immunity and which are produced by host cells that are invaded by listeriae translocating from the intestinal lumen to infect the pregnant host and embryonic tissues.

Selected Presentations and Publications

Suyemoto, M.M., Hamrick, T.S., Spears, P.A., Horton, J.A., Washington, I.D., Havell, E.A., Borst, L.A., and Orndorff, P.E. 2013. Extrauterine listeriosis in the gravid mouse influences embryonic growth and development.  PLoS 0ne 8(8):e72601.

Spears, P.A., Suyemoto, M.M., Hamrick, T.S., Wolf, R., Havell, E.A., and Orndorff, P.E.  2011. In vitro properties of a Listeria monocytogenes bacteriophage resistant mutant predict its efficacy as a live oral vaccine strain. Infect. Immun. 79:5001-5009.

Suyemoto MM, Spears PA, Hamrick TS, Barnes JA, Havell EA, Orndorff PE. PLoS One. 2010 Sep 27;5(9):e13000. doi: 10.1371/journal.pone.0013000.