Mac Law, Professor
Mac Law, DVM, PhD, DACVP
Professor of Pathology
Center for Comparative Medicine and Translational Research
Coordinator, One Health Intellectual Exchange Group
Coordinator, Pathology Focus Area
Associate Faculty Member, Dept. of Environmental and Molecular Toxicology
Diplomate, American College of Veterinary Pathologists
Research Interests: Aquatic Animal Models / Aquatic Ecotoxicology
My research focuses on mechanisms of carcinogenesis and comparative pathology of aquatic animals. The approach is twofold: (1) Mechanistic investigations using histopathology, molecular biology, and analytical techniques such as GC/mass spectrometry and HPLC with electrochemical detection to further establish small fish species as viable alternative animal models in toxicologic testing. Fish models such as the medaka, Oryzias latipes, and the zebrafish, Danio rerio, are used in these studies. (2) Laboratory, mesocosm, and field investigations designed to establish reliable biological markers in aquatic organisms as sentinels of environmental degradation. These biomarkers incorporate histopathology, clinical pathology, and immunologic techniques to determine the health of aquatic animals and ecosystems. Expected benefits of my research include increased knowledge of basic mechanisms of carcinogenesis, more rapid and economical testing of potential carcinogens, sensitive monitoring of aquatic pollutants, and better assessment of seafood safety.
- Determining the Barrier Function of the Chorion in the Fish Embryo Test.
- Evaluating the Seasonal Effects of Short-Term Temperature Fluctuations on Macroinvertebrates and Fish in the Susquehanna River near the Brunner Island Steam Electric Station, in collaboration with the Stroud Water Research Center.
- Assessment of Liver Neoplasia in Brown Bullheads in the Buffalo River, New York, in collaboration with ENVIRON International Corp.
- Development of Diagnostic Methods to Improve the Health Status of Ohio Freshwater Mussels, in collaboration with the Morris Animal Foundation
Selected Recent Publications
Hobbie KR, DeAngelo AB, Winn RN, Law JM (2009) Toward a molecular equivalent dose: use of the medaka model in comparative risk assessment. Comparative Biochemistry and Physiology: Toxicology & Pharmacology Part C 149: 141-151 (on-line: http://dx.doi.org/10.1016/j.cbpc.2008.07.013 ).
Jima DD, Shah RN, Orcutt TM, Joshi D, Law JM, Litman GW, Trede NS, Yoder JA (2009) Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity. Molecular Immunology 46: 1505–1516.
Freeman KS, Lewbart GA, Robarge WP, Harms CA, Law JM, Stoskopf MK (2009) Characterizing eversion syndrome in captive scyphomedusa jellyfish. American Journal of Veterinary Research (in press).
Spitsbergen JM, Blazer VS, Bowser PR, Cheng KC, Cooper KR, Cooper TK, Frasca S, Groman DB, Harper CM, Law JM, Marty GD, Smolowitz RM, St. Leger J, Wolf DC, Wolf JC (2009) Finfish and aquatic invertebrate pathology resources for now and the future. Comparative Biochemistry and Physiology: Toxicology & Pharmacology Part C 149: 249-257.
Kent ML, Feist SW, Harper C, Hoogstraten-Miller S, Law JM, Sánchez-Morgado JM, Tanguay R, Sanders G, Spitsbergen J, Whipps CM (2009) Recommendations for control of pathogens and infectious diseases in fish research facilities. Comparative Biochemistry and Physiology: Toxicology & Pharmacology Part C 149: 240-248.
Wooten JG, Blikslager AT, Ryan KA, Marks SL, Law JM, Lascelles BDX (2008) Cyclooxygenase expression and prostanoid production in the canine pylorus and duodenum in dogs administered non-steroidal anti-inflammatory drugs. American Journal of Veterinary Research 69: 457-464.
Law M, Elmore S. (2008). Chapter 16: Mechanisms of Cell Death. In: Molecular and Biochemical Toxicology, 4th Edition, RC Smart and E Hodgson (Eds.), John Wiley and Sons, Inc., Hoboken, New Jersey, pp. 287-318.
Harms CA, Christian LS, Burrus O, Hopkins WB, Pandiri AKR, Law JM, Wolf KN, Butler CM, Lewbart GA (2008) Cryotherapy for removal of a premaxillary mass from a chain pickerel using an over-the-counter wart remover. Exotic DVM 10: 15-17.
Choi K, Harms C, Lehmann DW, Law JM (2007) Acute hypoxia triggers immunocompromise in tilapia (Oreochromis niloticus). Journal of Aquatic Animal Health 19: 128-140.
Cachot J, Law M, Pottier D, Peluhet L, Norris M, Budzinsk H, Winn R (2007) Characterization of toxic effects of sediment-associated organic pollutants using the λ transgenic medaka. Environmental Science and Technology 41: 7830-7836.
Johnson AK, Law JM, Harms CA, Levine JF (2007) Multi-tiered health assessment of Atlantic menhaden in the Pamlico River, North Carolina. Journal of Aquatic Animal Health 19: 205-214.
Levine JF, Law M, Corsin F. (2006). Chapter 7: Bivalves. In: Invertebrate Medicine, G. Lewbart (Ed.), Blackwell Publishing, Ames, Iowa, pp. 91-115.
Tuttle AD, Law JM, Harms, CA, Lewbart GA, Harvey SB (2006) Evaluation of the gross and histologic reactions to five commonly used suture materials in the skin of the African clawed frog (Xenopus laevis). Journal of the American Association for Laboratory Animal Science 45: 31-35.