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Siddhartha "Sid" Thakur, BVSc, MVSc, PhD

Thakur

Swine Health and Production Medicine
Associate Professor, Molecular Epidemiology

Office: 490, CVM Research Building
Phone: 919.513.0729
Fax: 919.515.304
Email: sthakur@ncsu.edu
Thakur Lab Websitewww.tmelab.org

Core Leader: Emerging, Infectious and Zoonotic Diseases, CCMTR

Concentration Leader: Population Medicine, Comparative Biomedical Sciences

Course Involvement

  • VMP 916: Preventive Health Maintenance and Animal Production I
  • VMP936: Preventive Herd Health and Management II
  • VMP 964: Swine and Poultry Health
  • VMP 971: Food Animal Diagnostics for Disease Diagnosis, Control, and Population Surveillance
  • VMP 972: Ruminant Pharmacology
  • VMP 974: Food Supply Veterinary Medicine
  • VMP 984: Swine Health and Production
  • VMP 991-115: Swine Medicine Selective

Graduate Courses

  • FS 520: Pre-Harvest Food Safety
  • CBS 565: Fundamentals of Biomedical Sciences
  • One Health Intellectual Exchange Group (IEG) Series

Education/Training

  • Oakridge Research Associated Universities Postdoctoral Fellow, Center for Veterinary Medicine, Food and Drug Administration, Laurel, Maryland
  • PhD, Population Medicine, North Carolina State University
  • MS, Veterinary Science in Veterinary Public Health, Indian Veterinary Research Institute
  • BS, Veterinary Science and Animal Husbandry, Gobind Ballabh Pant Univeristy of Agriculture and Technology

Biography

Dr. Sid Thakur is an Associate Professor in the College of Veterinary Medicine at NC State University.  He received his Bachelor of Veterinary Science and Animal Husbandry from Gobind Ballabh Pant University of Agriculture and Technology (Udham Singh Nagar, India) and   Master of Veterinary Science in Veterinary Public Health at the Indian Veterinary Research Institute (Izatnagar, India).  He earned his Ph.D. in Population Medicine at the College of Veterinary Medicine, NC State University where his research focus was on comparing multidrug resistant Campylobacter isolated from swine raised in commercial and antimicrobial free production systems.  Prior to joining the faculty at NC State University, he was an Oakridge Research Associated Universities Postdoctoral Fellow at Center for Veterinary Medicine, Food and Drug Administration, Laurel, Maryland. At FDA, Dr. Thakur was involved in developing a DNA Microarray for the analysis of multi-drug resistant enteric pathogens isolated from retail meat.

Dr. Thakur`s research at NC State focuses on the molecular epidemiology of multi-drug resistant bacterial Salmonella and Campylobacter in the realms of pre-harvest food safety.  His recent research focus has been studying the transmission of foodborne pathogens from food animals to fresh produce farms. Dr. Thakur has authored or co-authored 30 peer reviewed publications and is currently editing a book on Pre Harvest Food Safety for the American Society for Microbiology. He is the chair of the International Association for Food Protection (IAFP) Pre Harvest Food Safety professional development group (PDG), and serves on the Journal of Food Protection management committee. He was awarded the Larry Beuchat Young Researcher Award at the 2012 IAFP annual meeting in Providence, RI.

Honors and Awards

Research

The major focus of Dr. Thakur research is to fill critical knowledge gaps that exist in the complex chain of events that lead to the development of antimicrobial resistance in bacterial pathogens that affect animal and human health. I espouse the concepts of “One Health” and use its principals to study the impact of interplay between animals, humans and their environment on the dissemination and persistence of antimicrobial resistant (AR) bacterial strains.  My research work is based on two predominant themes which are centered on food safety and public health.  The first revolves around understanding the phenotypic and genotypic similarity and/or diversity of AR bacterial strains reported in animals and humans.  This involves characterizing and elucidating the mechanisms of antimicrobial resistance at the molecular level, analyzing the DNA fingerprint patterns and determining the risk factors that predispose the animals and humans to infections by these strains.  The second theme is focused on using phylogenetics to study the evolution of AR bacterial strains at the population level. In this, we use molecular methods to study pathogen evolution on an evolutionary scale.

Research in Dr. Thakur lab is focused on understanding the molecular epidemiology of important multidrug resistant (MDR) food borne pathogens at the pre-harvest and post-harvest food safety levels. Our specific goal is to determine the dynamics of Salmonella, Campylobacter and Clostridium in food animals, retail meat, humans and the environment. With this information, we plan to achieve our long term goal of reducing the burden of infections caused by bacterial pathogens in food animals and humans by:

  1. Determining the risk factors and understanding the dissemination of antimicrobial resistant strains in animals, humans and their environment,
  2. Characterizing and elucidating the mechanisms of antimicrobial resistance at the molecular level,
  3. Understanding the genotypic diversity and population dynamics of these bacterial populations through phylogenetic analysis,
  4. Developing diagnostic methods that will aid in the rapid identification and characterization of bacterial pathogens and,
  5. Conveying the results of these studies to the stakeholders and developing new curricula aimed at providing education and training of veterinary, animal and food science students.

Selected Publications