Susan Tonkonogy, PhD
Director, of the Gnotobiotic Animal Core of the Center for Gastrointestinal Biology and Disease.
PhD: Harvard University
1) Swiss Institute for Experimental
2) Duke University Medical Center
My current research focuses on cytokine mediated regulation of immunity and inflammation in the intestinal tract. Our studies are designed to determine how the intestinal immune response is involved in initiation and perpetuation of chronic intestinal inflammation that occurs in human inflammatory bowel disease.
Colitis Induced by Immune Responses to Luminal Bacteria
The aim of our current studies is to elucidate the role of virulence gene products on the development of enterocolitis in IL-10 deficient mice. Our hypothesis is that persistent exposure of previously germ-free mice to invasive, translocating, intracellular commensal bacteria induces bacterial antigen-driven T cell responses that cause chronic intestinal inflammation.
Dr. R. Balfour Sartor, University of North Carolina, Chapel Hill, School of Medicine
Albright CA, Sartor RB, Tonkonogy SL. 2009 Endogenous antigen presenting cell-derived IL-10 inhibits T lymphocyte responses to commensal enteric bacteria. Immunol Lett 123:77-87.
Moran JP, Walter J, Tannock GW, Tonkonogy SL, Sartor RB. 2009. Bifidobacterium animalis causes extensive duodenitis and mild colonic inflammation in monoassociated interleukin-10 deficient mice. Inflamm Bowel Dis 15:1022-1031.
Liu B, Tonkonogy SL, Sartor RB. 2011. IL-10 produced by antigen presenting cells inhibits bacterial-responsive TH1/TH17 cells and suppresses colitis in mice. Gastroenterology 141:653-62.
Steck N, Hoffmann M, Irina S, Kim S, Hahne H, Tonkonogy SL, Mair K, Krueger D, Pruteanu M, Shanahan F, Vogelmann R, Schemann M, Küster B, Sartor RB, Haller D. 2011. Bacterial proteases contribute to intestinal inflammation by impairing mucosal barrier function in the susceptible host. Gastroenterology 141:959-71.
Anna Yedinak – Research Technician
CVM Main Building, Room B313,B315
Gnotobiotic Animal Core, Center for Gastrointestinal Biology and Disease