Dr. H. John Barnes
Professor, Poultry Health Management
Diplomate, American College of Veterinary Pathologists
Diplomate, American College of Poultry Veterinarians
Phone: 919.513.6273
Fax: 919.513.6464
Email: john_barnes@ncsu.edu
Education
- BS - Kansas State University, 1969 (Summa Cum Laude)
- DVM - Kansas State University, 1970
- PhD - Ahmadu Bello University (Nigeria), 1976
Areas of Research/Study
- Pathology of Birds
- Emerging Avian Diseases
- Avian Models of Ovarian Cancer
- Interaction of Management and Disease
- Skeletal Diseases of the Spine
- Turkey Diseases
- Pathogenesis of Avian Diseases, especially Enteric & Respiratory Diseases
Birds are highly specialized animals that have evolved flight as their primary means of survival. Weight and its distribution are important in maintaining the ability to fly. All of the cells, tissues, and systems of flying birds have evolved to provide maximum function with minimum weight. There is little or no reserve or backup defense mechanisms. When disease affects an individual or flock of birds, it often progresses differently than a similar disease would in mammals. Studying how birds respond to an injurious agent is the basis of avian pathology. The tissue and response differences between birds and other animals make avian pathology a distinct field of study within the broad area of veterinary pathology.
My work is primarily with poultry, although other birds, including free-living, captive, and companion birds, are occasionally studied. While disease control in poultry flocks has improved greatly over the past several decades, losses still amount to approximately 10% of all production. Much of the loss comes from production diseases that cannot be attributed to specific disease organisms. Rather, they result from poorly understood, complex interactions among a number of factors such as environment, genetics, nutrition, parasites, and infectious agents. Control of these diseases is based on management aimed at minimizing the impact of the various factors. In addition to known diseases and production diseases, new diseases due to emerging or re-emerging causes arise with astonishing regularity. Identifying new diseases quickly and accurately is essential to their control. Food-borne illnesses continue to be a societal concern as is the increasing recognition of antimicrobial resistance. Minimizing the organisms that cause food-borne illnesses and judiciously using antimicrobials for specific purposes are goals challenging the poultry industry and poultry veterinarian.
I use avian pathology as a basis for diagnosing known and unknown diseases and to study the mechanisms and causes of diseases in birds, especially those affecting the reproductive, intestinal, and respiratory tracts. Emphasis is on studying naturally occurring disease. Experimental studies are sometimes done to confirm observations arising from clinical findings or to reproduce a natural disease for examination at specific times post-exposure. A long-range goal is to collect material and information on avian pathology for future reference and educational purposes.
Currently, I am involved in research projects comparing ovarian cancer in chickens and turkeys to that in women, transmissible viral proventriculitis in broiler chickens, causes of early lay mortality and male infertility in broiler breeders, and pathogenesis of enterococcal vertebral osteoarthritis, and emerging disease of male chickens. Previously, considerable effort was directed toward studying a severe form of Poult Enteritis Complex known as Poult Enteritis Mortality Syndrome.
Appointments and Honors
- Professor, Department of Population Health & Pathobiology, College of Veterinary Medicine, North Carolina State University; Full Member Graduate Faculty, 1982-present
- Associate Professor, Veterinary Medical Research Institute, College of Veterinary Medicine, Iowa State University; Associate Member, Graduate Faculty, 1978-1982
- Assistant Professor, Veterinary Medical Research Institute, College of Veterinary Medicine, Iowa State University, 1975-1978
- Lecturer, Department of Pathology, Faculty of Veterinary Medicine, Ahmadu Bello University (Nigeria), 1971-1975
- Instructor, Department of Pathology, College of Veterinary Medicine, Kansas State Univ., 1970
- President, American Association of Avian Pathologists, 1991-1992
- Special Service Award, American Association of Avian Pathologists, 1994
- Phibro Animal Health Excellence Award, American Association of Avian Pathologists, 2005
- Editorial Board, Avian Diseases, 1979-2000
- Dedication, Diseases of Poultry, 12th Edition, 2008
- Co-editor, Diseases of Poultry, Iowa State University Press, 8th, 9th, 10th ,and 11th Editions
- Outstanding Extension Service Award, North Carolina State University, 2005
- Academy of Outstanding Faculty Engaged in Extension, North Carolina State University, 2005
- Outstanding Teacher Award (Class of 1985), 1984
- Borden Award for highest GPA in graduating class, 1970
- Clinical Proficiency Award, 1970
Representative Publications
Scientific Papers
- Hakim AA, Barry CP, Barnes HJ, Anderson KE, Petitte J, Whitaker R, Lancaster JM, Wenham RM, Carver DK, Turbov J, Berchuck A, Kopelovich L, Rodriguez GC. Ovarian adenocarcinomas in the laying hen and women share similar alterations in p53, ras, and HER-2/neu. Cancer Prev Res. 2:114-121, 2009
- Reynolds TL, Barnes HJ, Wolfe B, Lu L, Camp DM, Malarkey DE. Bilateral nocardial endophthalmitis in a Prothonotary Warbler (Protonotaria citrea). Vet Pathol 46:120-123, 2009
- Monleon R, Martin M, Barnes HJ. Bacterial orchitis and epididymo-orchitis in broiler breeders. Avian Pathol 37:613-617, 2008
- Martin MP, Bouck KP, Helm J, Dykstra MJ, Wages DP, Barnes HJ. Disseminated Aspergillus flavus infection in broiler breeder pullets. Avian Dis 51:626-31, 2007
- Osorio C, Fletcher O, Dykstra MJ, Post K, Barnes HJ. Comb candidiasis affecting roosters in a broiler breeder flock. Avian Dis. 51:618-622, 2007
- Sanei B, Barnes HJ, Vaillancourt JP, Ley DH. Experimental infection of chickens and turkeys with Mycoplasma gallisepticum reference strain S6 and North Carolina field isolate RAPD type B. Avian Dis 51:106-111, 2007
- Guy JS, Smith LG, Evans ME, Barnes HJ. Experimental reproduction of transmissible viral proventriculitis by infection of chickens with a novel adenovirus-like virus (isolate R11/3). Avian Dis 51:58-65, 2007
- Kristen Roza, Martin M, Barnes HJ. Litter impaction of the lower intestinal tract in male broiler breeders. Avian Dis 50:460-462, 2006
- Alfonso M, Barnes HJ. Neonatal osteomyelitis associated with Staphylococcus aureus in turkey poults. Avian Dis 50:148-151, 2006
- Alfonso M, Adochiles L, Hendrickson VM, Carver DK, Rodriguez GC, Barnes HJ. Metastatic adenocarcinoma in the lungs of older laying hens. Avian Dis 49:430-432,2005
- Lee BC, Reimers N, Barnes HJ, D'Lima C, Carver D, Kathariou S. Strain persistence and fluctuation of multiple-antibiotic resistant Campylobacter coli colonizing turkeys over successive production cycles. Foodborne Pathog Dis 2:103-10, 2005
- Guy JS, Barnes HJ, Smith L, Owen R, Fuller FJ. Partial characterization of an adenovirus-like virus isolated from broiler chickens with transmissible viral proventriculitis. Avian Dis 49:344-351, 2005
- Smith K, Reimers N, Barnes HJ, Lee BC, Siletzky R, Kathariou S. Campylobacter colonization of sibling turkey flocks reared under different management conditions. J Food Protect 67:1463-1468, 2004
- Gazdzinski P, Barnes HJ. Venereal colibacillosis (acute vaginitis) in turkey breeder hens. Avian Dis 48:681-685, 2004
- Clark S, De Gussem K, Barnes HJ. Flagellated protozoan infections in turkeys. World Poultry Turkeys Special 5:20-24, 2003
- Pakpinyo S, Ley DH, Barnes HJ, Vaillancourt, J-P, Guy JS. Enhancement of enteropathogenic Escherichia coli pathogenicity in young turkeys by turkey coronavirus infection. Avian Dis 47:396-405, 2003
- Matthews KG, Danova NA, Newman H, Barnes HJ, Phillips L. Ratite cancellous xenograft; effects on avian fracture healing. Vet Comp Orthop Traumatol 16:50-58, 2003
Books/Book Chapters
- Barnes HJ, Fletcher OJ, Aziz TA. Hemic System. In Avian Histopathology, 3rd ed., Fletcher OJ, Aziz TA, eds. AAAP, Jacksonville, FL, 2008. pp. 1-23
- Barnes HJ, Fletcher OJ, Aziz TA. Reproductive System. In Avian Histopathology, 3rd ed., Fletcher OJ, Aziz TA, eds. AAAP, Jacksonville, FL, 2008. pp. 348-391
- Barnes HJ, Nolan L, Vaillancourt J-P. Colibacillosis. In Diseases of Poultry, 12th ed, Saif YM, Fadly AA, Glisson JR, McDougald LR, Nolan L, Swayne DE, ISU Press, Ames, IA., 2008. pp. 691-732
- Barnes HJ. Clostridial Diseases. Introduction. In Diseases of Poultry, 12th ed, Saif YM, Fadly AA, Glisson JR, McDougald LR, Nolan L, Swayne DE, ISU Press, Ames, IA., 2008. pp. 865-866
- Barnes HJ. Other Bacterial Diseases. Introduction. In Diseases of Poultry, 12th ed, Saif YM, Fadly AA, Glisson JR, McDougald LR, Nolan L, Swayne DE, ISU Press, Ames, IA., 2008. pp. 891-892
- Barnes HJ. Miscellaneous and Sporadic Bacterial Infections. In Diseases of Poultry, 12th ed, Saif YM, Fadly AA, Glisson JR, McDougald LR, Nolan L, Swayne DE, ISU Press, Ames, IA, 2008. pp. 952-970
- Barnes HJ. Macrorhabdus (Megabacteria). In Diseases of Poultry, 12th ed, Saif YM, Fadly AA, Glisson JR, McDougald LR, Nolan L, Swayne DE, ISU Press, Ames, IA, 2008. pp. 1008
- Vaillancourt J-P, Barnes HJ. Coliform cellulitis. In Diseases of Poultry, 12th ed, Saif YM, Fadly AA, Glisson JR, McDougald LR, Nolan L, Swayne DE, ISU Press, Ames, IA, 2008. pp. 732-737