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Swine Health and Production

Departmental Phone: 919.513.6240
Fax: 919.513.6464


Adjunct Faculty

  • Jeremy Pittman
  • Matthew Turner

Laboratory Links


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Swine Health and Production Medicine


North Carolina is the number two swine state in the U.S. The Swine Health & Production Medicine (SHPM) Faculty are actively engaged with the NC swine industry though research and outreach and are committed to training future veterinarians to serve the industry and private clients



The SHPM faculty research programs deliver cutting-edge information to support the U.S. Swine industry. All SPHM faculty are engaged in research programs that are nationally and internationally recognized.

SHPM Faculty at NC State have their primary focus in the following areas of research:

Reproductive physiology and immunology research is aimed at investigating the influence of cytokines and the immune system on corpus luteum function in the pig.

Molecular epidemiology is focused on understanding important multidrug resistant (MDR) food borne pathogens at the pre-harvest and post-harvest food safety levels with the specific goal to determine the dynamics of Salmonella, Campylobacter and Clostridium in swine, retail meat and humans.

Gastrointestinal physiology seeks to understand the pathophysiology of important enteric disease affecting swine with the ultimate goal of identifying improved prevention and therapeutic strategies to mitigate these costly diseases.  Special emphasis is on stress physiology of the pig and its role in swine intestinal health and disease susceptibility.


Education and Outreach

Teaching for veterinary students is accomplished at the Teaching Animal Unit (TAU), in Swine Selectives for students in the first three classes of the professional curriculum, senior rotations for students, and in lecture primarily during year 3 of the DVM curriculum.

SHPM Faculty develop strong relationships with practicing swine veterinarians and management within the industry in North Carolina. They collaborate with DVM's and their clients to provide better teaching opportunities for our students and graduate students.

The Faculty are actively engaged in the international swine industry, including a training program for international veterinarians who desire to learn more about large scale swine production in order to improve the health of swine in their countries.


Press and Publications





Peer Reviewed

1.         Blikslager AT, Moeser AJ, Gookin JL, Jones SL, and Odle J. Restoration of barrier function in injured intestinal mucosa. Physiol Rev 87: 545-564, 2007.

3.         Corl BA, Odle J, Niu X, Moeser AJ, Gatlin LA, Phillips OT, Blikslager AT, and Rhoads JM. Arginine Activates Intestinal p70S6k and Protein Synthesis in Piglet Rotavirus Enteritis. J Nutr 138: 24-29, 2008.

4.         Dorr PM, Baker RB, Almond GW, Wayne SR, and Gebreyes WA. Epidemiologic assessment of porcine circovirus type 2 coinfection with other pathogens in swine. Javma-Journal of the American Veterinary Medical Association 230: 244-250, 2007.

5.         Dorr PM, Gebreyes WA, and Almond GW. Porcine reproductive and respiratory syndrome virus: Age and management system disease modeling for pathogenic co-infection. Journal of Swine Health and Production 15: 258-263, 2007.

6.         Dorr PM, Madson D, Wayne S, Scheidt AB, and Almond GW. Impact of pH modifiers and drug exposure on the solubility of pharmaceutical products commonly administered through water delivery systems. Journal of Swine Health and Production 17: 217-222, 2009.

7.         Dorr PM, Nemechek MS, Scheidt AB, Baynes RE, Gebreyes WA, and Almond GW. Water-flow variation and pharmacoepidemiology of tetracycline hydrochloride administration via drinking water in swine finishing farms. Javma-Journal of the American Veterinary Medical Association 235: 299-304, 2009.

8.         Dorr PM, Tadesse DA, Zewde BM, Fry P, Thakur S, and Gebreyes WA. Longitudinal Study of Salmonella Dispersion and the Role of Environmental Contamination in Commercial Swine Production Systems. Applied and Environmental Microbiology 75: 1478-1486, 2009.

9.         Fusco WG, Afonina G, Nepluev I, Cholon DM, Choudhary N, Routh PA, Almond GW, Orndorff PE, Staats H, Hobbs MM, Leduc I, and Elkins C. Immunization with the Haemophilus ducreyi Hemoglobin Receptor HgbA with Adjuvant Monophosphoryl Lipid A Protects Swine from a Homologous but Not a Heterologous Challenge. Infection and Immunity 78: 3763-3772.

10.       Gebreyes WA, Thakur S, Dorr P, Tadesse DA, Post K, and Wolf L. Occurrence of spvA Virulence Gene and Clinical Significance for Multidrug-Resistant Salmonella Strains. Journal of Clinical Microbiology 47: 777-780, 2009.

11.       Hansen SL, Ashwell MS, Moeser AJ, Fry RS, Knutson MD, and Spears JW. High dietary iron reduces transporters involved in iron and manganese metabolism and increases intestinal permeability in calves. J Dairy Sci 93: 656-665.

12.       Little D, Brown SA, Campbell NB, Moeser AJ, Davis JL, and Blikslager AT. Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunum. Am J Vet Res 68: 614-624, 2007.

13.       Mason SE, Baynes RE, Almond GW, Riviere JE, and Scheidt AB. Pharmacology of tetracycline water medication in swine. Journal of Animal Science 87: 3179-3186, 2009.

14.       Mason SE, Baynes RE, Buur JL, Riviere JE, and Almond GW. Sulfamethazine water medication pharmacokinetics and contamination in a commercial pig production unit. Journal of Food Protection 71: 584-589, 2008.

15.       Moeser AJ, and Blikslager AT. Mechanisms of porcine diarrheal disease. J Am Vet Med Assoc 231: 56-67, 2007.

16.       Moeser AJ, Blikslager AT, and Swanson C. Determination of minimum alveolar concentration of sevoflurane in juvenile swine. Res Vet Sci 84: 283-285, 2008.

17.       Moeser AJ, Klok CV, Ryan KA, Wooten JG, Little D, Cook VL, and Blikslager AT. Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig. Am J Physiol Gastrointest Liver Physiol 292: G173-181, 2007.

18.       Moeser AJ, Nighot PK, Engelke KJ, Ueno R, and Blikslager AT. Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, lubiprostone. Am J Physiol Gastrointest Liver Physiol 292: G647-656, 2007.

19.       Moeser AJ, Nighot PK, Roerig B, Ueno R, and Blikslager AT. Comparison of the chloride channel activator lubiprostone and the oral laxative Polyethylene Glycol 3350 on mucosal barrier repair in ischemic-injured porcine intestine. World J Gastroenterol 14: 6012-6017, 2008.

20.       Moeser AJ, Nighot PK, Ryan KA, Simpson JE, Clarke LL, and Blikslager AT. Mice lacking the Na+/H+ exchanger 2 have impaired recovery of intestinal barrier function. Am J Physiol Gastrointest Liver Physiol 2008.

21.       Moeser AJ, Nighot PK, Ryan KA, Wooten JG, and Blikslager AT. Prostaglandin-mediated inhibition of Na+/H+ exchanger isoform 2 stimulates recovery of barrier function in ischemia-injured intestine. Am J Physiol Gastrointest Liver Physiol 291: G885-894, 2006.

22.       Moeser AJ, Ryan KA, Nighot PK, and Blikslager AT. Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigs. Am J Physiol Gastrointest Liver Physiol 293: G413-421, 2007.

23.       Muley NS, van Heugten E, Moeser AJ, Rausch KD, and van Kempen TA. Nutritional value for swine of extruded corn and corn fractions obtained after dry milling. J Anim Sci 85: 1695-1701, 2007.

24.       Nighot PK, Moeser A, Ali RA, Blikslager AT, and Koci MD. Astrovirus infection induces sodium malabsorption and redistributes sodium hydrogen exchanger expression. Virology.

25.       Nighot PK, Moeser AJ, Ryan KA, Ghashghaei T, and Blikslager AT. ClC-2 is required for rapid restoration of epithelial tight junctions in ischemic-injured murine jejunum. Exp Cell Res 315: 110-118, 2009.

26.       Rhoads JM, Corl BA, Harrell R, Niu X, Gatlin L, Phillips O, Blikslager A, Moeser A, Wu G, and Odle J. Intestinal ribosomal p70(S6K) signaling is increased in piglet rotavirus enteritis. Am J Physiol Gastrointest Liver Physiol 292: G913-922, 2007.

27.       Sanz M, Roberts JD, Perfumo CJ, Alvarez RM, Donovan T, and Almond GW. Assessment of sow mortality in a large herd. Journal of Swine Health and Production 15: 30-36, 2007.

28.       Smith F, Clark JE, Overman BL, Tozel CC, Huang JH, Rivier JE, Blikslager AT, and Moeser AJ. Early weaning stress impairs development of mucosal barrier function in the porcine intestine. Am J Physiol Gastrointest Liver Physiol 298: G352-363.

29.       Thakur S, and Gebreyes WA. Phenotypic and Genotypic Heterogeneity of Campylobacter coli Within Individual Pigs at Farm and Slaughter in the US. Zoonoses and Public Health 57: 100-106.

30.       Thakur S, Morrow WEM, Funk JA, Bahnson PB, and Gebreyes WA. Molecular epidemiologic investigation of Campylobacter coli in swine production systems, using multilocus sequence typing (vol 72, pg 5666, 2006). Applied and Environmental Microbiology 74: 342-342, 2008.

31.       Thakur S, Putnam M, Fry PR, Abley M, and Gebreyes WA. Prevalence of antimicrobial resistance and association with toxin genes in Clostridium difficile in commercial swine. American Journal of Veterinary Research 71: 1189-1194.

32.       Thakur S, Tadesse DA, Morrow M, and Gebreyes WA. Occurrence of multidrug resistant Salmonella in antimicrobial-free (ABF) swine production systems. Veterinary Microbiology 125: 362-367, 2007.

33.       Thakur S, White DG, McDermott PF, Zhao S, Kroft B, Gebreyes W, Abbott J, Cullen P, English L, Carter P, and Harbottle H. Genotyping of Campylobacter coli isolated from humans and retail meats using multilocus sequence typing and pulsed-field gel electrophoresis. Journal of Applied Microbiology 106: 1722-1733, 2009.

34.       Thakur S, Zhao SH, McDermott PF, Harbottle H, Abbott J, English L, Gebreyes WA, and White DG. Antimicrobial Resistance, Virulence, and Genotypic Profile Comparison of Campylobacter jejuni and Campylobacter coli Isolated from Humans and Retail Meats. Foodborne Pathogens and Disease 7: 835-844.

35.       van Kempen TA, van Heugten E, Moeser AJ, Muley NS, and Sewalt VJ. Selecting soybean meal characteristics preferred for swine nutrition. J Anim Sci 84: 1387-1395, 2006.


Abstracts – in progress

Conference Proceedings – in progress