Heather Shive, DVM, PhD
Veterinary Anatomic Pathology
Office: 248, CVM Research Building
Phone: (919) 513-6296
- Diplomate, American College of Veterinary Pathologists
- PhD, Veterinary Medical Sciences, University of Maryland
- DVM, North Carolina State University
- BS, Biology, University of Arizona
Cancer is a genetic disease, initiated and driven by mutations in genes that disrupt normal cell functions and promote tumor initiation and progression. Cancers develop a broad spectrum of genetic disruptions, and it is often difficult to identify changes that contribute to tumor development. The zebrafish model (Danio rerio) is a powerful tool for analyzing genetic contributors to cancer risk: zebrafish exhibit conserved genetic susceptibility to cancer, are highly amenable to genetic manipulation, and can be analyzed in large numbers. The long-term goal of my research program is to investigate genetic mediators of carcinogenesis with the zebrafish model. This research will additionally incorporate environmental and toxicologic factors that may act in synergy with genetic factors to influence cancer risk.
Honors and Awards
- Outstanding Alumnus – Early Career Award, University of Maryland, 2014
- National Institutes of Health 2011 Fellows Award for Research Excellence, 2010
- Graduate Merit/AFS Fellowship, 2004 – 2006
- Summa cum Laude, University of Arizona, 2000
- Phi Beta Kappa National Honor Society, 2000
- Undergraduate Biology Research Program, University of Arizona, 1998 – 2000
- Honors Program, University of Arizona, 1996 – 2000
- Paldurai A, Kim SH, Nayak B, Xiao S,Shive H, Collins PL, Samal SK. Evaluation of the contributions of individual viral genes to newcastle disease virus virulence and pathogenesis. J Virol. 2014 Aug 1;88(15):8579-96.
- Shive HR, West RR, Embree LJ, Golden CD, Hickstein DD. brca2 and tp53 collaborate in tumorigenesis in zebrafish. PLoS One 2014 10.1371/journal.pone.0087177.
- Kim SH, Xiao S, Shive H, Collins PL, Samal SK. Mutations in the fusion protein cleavage site of avian paramyxovirus serotype 4 confer increased replication and syncytium formation in vitro but not increased replication and pathogenicity in chickens and ducks. PLoS One 2013 Jan;8(1):e50598.
- Bauer TR Jr, Tuschong LM, Calvo KR, Shive HR, Burkholder TH, Karlsson EK, West RR, Russell DW, Hickstein DD. Long-term follow-up of foamy viral vector-mediated gene therapy for canine leukocyte adhesion deficiency. Mol Ther. 2013 May;21(5):964-72.
- Shive HR. Zebrafish models for human cancer. Veterinary Pathology 2012 Nov; doi: 10.1177/0300985812467471.
- Kim SH, Xiao S, Shive H, Collins PL, Samal SK. Replication, neurotropism, and pathogenicity of avian paramyxovirus serotypes 1-9 in chickens and ducks. PLoS One 2012 Apr;7(4):e34927.
- Wei BR, Simpson RM, Johann DJ, Dwyer JE, Prieto DA, Kumar M, Ye X, Luke B, Shive HR, Webster JD, Hoover SB, Veenstra TD, Blonder J. Proteomic profiling of H-Ras-G12V induced hypertrophic cardiomyopathy in transgenic mice using comparative LC-MS analysis of thin fresh-frozen tissue sections. J Proteome Res. 2012 Mar 2;11(3):1561-70.
- Samuel AS, Subbiah M, Shive H, Collins PL, Samal SK. Experimental infection of hamsters with avian paramyxovirus serotypes 1 to 9. Vet Res. 2011 Feb 23;42(1):38.
- Shive HR, West RR, Embree LJ, Azuma M, Sood R, Liu PP, Hickstein DD. brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19350-5.
- Russell-Lodrigue KE, Andoh M, Poels MW, Shive HR, Weeks BR, Zhang GQ, Tersteeg C, Masegi T, Hotta A, Yamaguchi T, Fukushi H, Hirai K, McMurray DN, Samuel JE. Coxiella burnetii isolates cause genogroup-specific virulence in mouse and guinea pig models of acute Q fever. Infect Immun. 2009 Dec;77(12):5640-50.
- Andoh M, Zhang G, Russell-Lodigue KE, Shive HR, Weeks BR, Samuel JE. T cells are essential for bacterial clearance and IFN-g, TNF-a, and B cells are crucial for disease development in Coxiella burnetii infection in mice. Infect Immun. 2007 July 75(7):3245-3255.
- Shive H, Mohammed F, Osterstock J, Porter B, Mansell J. Liposarcoma in the nasal cavity of a cow. Vet Pathol. 2006 Sep;43(5):793-7
- Pepperberg IM, Shive HR. Simultaneous development of vocal and physical object combinations by a Grey parrot (Psittacus erithacus): bottle caps, lids, and labels. J. Comp Psychol 2001 Dec 115(4):376-84.