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Current Seizure Studies and Events at NCSU-CVM

Boy with dog

(Recruiting for cases)

Recruiting October 2014:


Canine Keppra Extended Release Pharmacokinetic Study: New October 2014

Recruitment is open for dogs with epilepsy that are being treated with Keppra XR (levetiracetam extended release)) and Phenobarbital (group I) Keppra XR and Zonisamide (Zonegran) (group II) , or Keppra XR alone (group III) for a Pharmacokinetic study. This study is being conducted at North Carolina State University-College of Veterinary Medicine, under the direction of Dr. Karen Munana, DVM, DACVIM (Neurology).

If your dog has been diagnosed with epilepsy, and is receiving the drugs listed above in any of the 3 groups listed, we are interested in sampling your pet to determine how Keppra XR interacts with the other anticonvulsants through sequential blood sampling in a one-day study. All blood levels will be provided to the owners at no-charge. If you are interested in more information regarding this project, or to see if your pet qualifies, please contact Julie Nettifee or 919-513-6812. We would like to thank Emma's Fund (Epil K-9) for their support of this project and Epil K-9 and Toby's Foundation for assistance with publicity for this project.

English Shepherd Genotype Project in Canine Epilepsy

Building Links to Greater Knowledge, Treatments

Investigations underway at North Carolina State University-College of Veterinary Medicine are examining how genetics may play a role in why some dogs respond poorly to seizure medication. Dr. Karen Munana, associate professor of neurology is collaborating with researchers in Japan, in the first investigation, which evaluates the effect of a specific known genetic deletion seen in herding dogs that impacts seizure control. This deletion makes dogs more susceptible to side effects of certain drugs, and the study aims to determine whether it also affects the response to seizure medication. The study is seeking English Shepherds with seizures that are being treated with seizure medication to participate. For more information regarding the results of this project please contact study coordinator or 919-513-6812.


Use of Accelerometry to Detect Seizures in Dogs

A Pilot study is underway at North Carolina State University College of Veterinary Medicine exploring the use of an activity monitor to detect canine seizures. Dogs participating in this study must have seizures on a monthly basis, wear a collar throughout the day (even when kennelled) and live local to Raleigh, NC. In addition, owners must have internet access at home and own either a smartphone or android phone. For more information, contact or call 919-513-6812.