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Ghashghaei, Troy, Ph.D. (PI)

Troy Ghashghaei

 

Assistant Professor of Neurobiology
Ph.D.: Boston University
Postdoctoral: University of North Carolina at Chapel Hill
PI's Office Phone: (919) 513-6174
Fax: (919) 513-6465

Troy_Ghashghaei@ncsu.edu

 

Current Research

 

Projects in our laboratory are focused on developmental neurobiology:

1. Development and aging of the adult stem cells and their ependymal niche in the forebrain. We use mouse genetics in combination with molecular, biochemical, and cell biological approaches to address fundamental questions regarding the functional significance of ependymal cells during development and aging.

Current projects are investigating:

a. Mechanisms driving differentiation of ependymal cells and their responses to various stimuli.

b. Mechanisms that help maintain ependymal homeostasis during aging.

2. Role of cell cycle regulators in symmetric and asymmetric divisions of neural stem cells in the developing and postnatal brain. We use mouse genetics, biochemical assays, and state-of-the-art imaging tools to understand mechanisms that regulate the decision of neural stem cells to divide symmetrically or asymmetrical in the embryonic and postnatal stem cell niches.

Current Projects are investigating:

a. Symmetric versus asymmetric decisions in dividing stem cells.

b. Cell-cell communication among clones of progenitors and their role in neuronal and glial fate specification.

 

Highly motivated postdoctoral fellows and graduate students interested in our research should contact Dr. Ghashghaei (Troy_Ghashghaei@ncsu.edu)

 

 

Lab Personnel


Postdoctoral Fellows

Nagendran Muthusamy

Nagendran Muthusamy
nagendran_muthusamy@ncsu.edu

promila

Promila Pagadala

pcpagada@ncsu.edu

xuying

Xuying Zhang
xzhang39@ncsu.edu

 

Graduate Students

Guanxi Xiao

Guanxi Xiao
gxiao@ncsu.edu

caroline

Caroline Johnson
cajohn14@ncsu.edu

Undergraduate Students

ammu

Akshitha Vijayakumar
avijaya2@ncsu.edu

jaclyn

Jaclyn Smith
jesmit11@ncsu.edu

Contact Information: 1060 William Moore Dr., CVM Research building, RB230 and RB236, Raleigh, NC 27607
Staff Office Phone: (919) 513-0955 Lab1 Phone: (919) 513-6840 Lab2 Phone: (919) 513-6841

 

Representative Publications

 

Muthusamy N., Vijayakumar A., Cheng J., Ghashghaei H.T.  (2014) A Knock-in Foxj1CreERT2::GFP mouse for recombination in epithelial cells with motile cilia. Genesis. [Epub ahead of print]

Liang H., Xiao G., Yin H., Hippenmeyer S., Horowitz J.M., Ghashghaei H.T. (2013) Neural development is dependent on the function of specificity protein 2 in cell cycle progression.  Development. 140(3):552-61.

Liang H., Hippenmeyer S., Ghashghaei H.T. (2012) A Nestin-cre transgenic mouse isinsufficient for recombination in early embryonic neural progenitors.  Biol Open. 1(12):1200-3. "Cover Illustration"

openbiocover

Nehrenberg D.L., Sheikh A., Ghashghaei H.T. (2012) Identification of neuronal loci involved with displays of affective aggression in NC900 mice. Brain Struct. Funct. DOI: 10.1007/s00429-012-0445-y.

Jacquet B.V., Muthusamy N., Sommerville L.J., Xiao G., Liang H., Zhang Y., Holtzman M.J., Ghashghaei H.T. (2011) Specification of a Foxj1-dependent lineage in the forebrain is required for embryonic-to-postnatal transition of neurogenesis in the olfactory bulb. Journal of Neuroscience. 31(25):9368-82.

Jacquet B.V., Ruckart P., Ghashghaei H.T. (2010) An organotypic slice assay for high-resolution time-lapse imaging of neuronal migration in the postnatal brain. J Vis Exp. (46). pii: 2486. doi: 10.3791/2486.

Jacquet B.V.,Salinas-Mondragon R., Liang H., Therit B., Buie J.D., Dykstra M., Campbell K., Ostrowski L.E., Brody S.L.,and Ghashghaei H.T. (2009) FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain. Development. 136, 4021-4031. "Featured article with Cover Illustration".

Development cover

Jacquet B.V., Patel M., Iyengar M., Liang H., Therit B., Salinas-Mondragon R., Lai C., Olsen J.C., Anton E.S., Ghashghaei H.T. (2009) Analysis of neuronal proliferation, migration and differentiation in the postnatal brain using equine infectious anemia virus-based lentiviral vectors. Gene Therapy. 16(8):1021-33.

Ghashghaei H.T., Weimer J.M., Schmid R.S., Yokota Y., McCarthy K.D., Popko B., Anton E.S. (2007)  Reinduction of ErbB2 in astrocytes promotes radial glial progenitor identity in adult cerebral cortex.   Genes Dev. 21(24): 3258-71.Faculty 1000Faculty of Biology 1000

Yokota, Y., Ghashghaei, H.T., Han, C., Watson, H., Campbell, K.J., Anton, E.S., (2007) Radial glial dependent and independent dynamics of interneuronal migration in the developing cerebral cortex. PLoS ONE. 2(8): e794.

Ghashghaei H.T., Lai C., and Anton E.S. (2007) Neuronal migration in the adult brain: are we there yet? Nature Reviews Neuroscience. 8(2):141-151.

Ghashghaei H.T., Weber J., Pevny L., Schmid R., Schwab M.H., Lloyd K.C., Eisenstat D.D., Lai C., Anton E.S. (2006)  The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone.  Proceeding of the National Academy of Sciences103(6): 1930-1935.

Anton E.S.*, Ghashghaei H.T.*, Weber J.L., McCann C., Fischer T.M., Cheung I.D., Gassmann M., Messing A., Klein R., Schwab M.H., Lloyd K.C.K., Lai C. (2004) Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain.  Nature Neuroscience 7(12): 1319-1328. *Authors contributed equally