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Nascone-Yoder, Nanette, PhD

Nanette Nascone-Yoder

 

Associate Professor

Ph.D., Harvard University, 1997
Assistant Professor, Eckerd College, 1997, tenured 2003
Associate Professor, Eckerd College, 2004

 

 

Phone: (919) 513-8284
Fax: (919) 513-7301
E-mail: Nanette_Nascone-Yoder@ncsu.edu
Lab Web page: http://www4.ncsu.edu/~nmnascon/



Research Interest:

*Intestinal malrotation occurs in as many as 1 in 500 human births (0.2% of the population) and poses significant risk for life-threatening complications in babies and children. No clear inheritance pattern has been identified for intestinal malrotation, suggesting a multifactorial etiology involving genetic, epigenetic and/or environmental causes.

*Normal digestive anatomy is a consequence of the dramatic elongation, left-right asymmetric looping and rotation of the primitive gut tube during fetal development, but the cellular and molecular mechanisms underlying these events in gut morphogenesis are poorly understood.

*Our lab employs chemical genetic strategies in amphibian embryos to investigate the mechanisms of digestive tract morphogenesis, understand the etiology of intestinal malrotation, and define the effects of chemicals and toxins on gut development.

Selected Publications:

Nascone, N. and M. Mercola (1995) An inductive role for the endoderm in Xenopus cardiogenesis. Development, 121, 515-523.

Nascone, N. and M. Mercola (1996) Endoderm and cardiogenesis: new insights. Trends in Cardiovascular Medicine, 6, 211-216.

Nascone, N. and M. Mercola (1997) Organizer induction determines left-right asymmetry in Xenopus. Developmental Biology, 189, 68-78.

Levin, M. and N. Nascone (1997) Two molecular models of initial left-right asymmetry generation. Medical Hypotheses, 49, 429-435.

Smith, D., R.C. Grasty, C.J. Tabin, and N. Nascone-Yoder (2000) The evolutionary relationships between the amphibian, avian and mammalian stomachs. Evolution and Development 2 (6), 348-359.

Gormley, J.P. and N. Nascone-Yoder (2003) Left and right contributions to the Xenopus heart: implications for asymmetric morphogenesis. Development, Genes and Evolution, 213, 390-398.

Muller, J.K., Prather, D. and N. Nascone-Yoder (2003) left-right asymmetric morphogenesis in the Xenopus digestive system. Developmental Dynamics. 228(4):672-82.

Lipscomb, K.J., Sablyak, A.R., Schmitt, C.E., Yoder, J.A. and N. Nascone-Yoder (2006) A role for retinoid signaling in left-right asymmetric digestive organ morphogenesis. Developmental Dynamics 235(8):2266-75.

Ledon-Rettig CC, Pfennig DW, Nascone-Yoder N. (2008) Ancestral variation and the potential for genetic accommodation in larval amphibians: implications for the evolution of novel feeding strategies. Evolution and Development 10(3):316-25.

Rachel A Reed, Mandy A Womble, Michel K Dush, Rhesa R Tull, Stephanie K Bloom, Allison R Morckel, Edward W Devlin, Nanette M Nascone-Yoder (2009) Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements. Dev Dyn 238: 12. 3111-3125

Mei-I Chung, Nanette M Nascone-Yoder, Stephanie A Grover, Thomas A Drysdale, John B Wallingford (2010) Direct activation of Shroom3 transcription by Pitx proteins drives epithelial morphogenesis in the developing gut. Development 137: 8. 1339-1349

Michael K. Dush, Andrew L. McIver, Meredith A. Parr, Douglas D. Young, Julie Fisher, Donna R. Newman, Philip L. Sannes, Marlene L. Hauck, Alexander Deiters, Nanette Nascone-Yoder. "Heterotaxin: A TGF-รข Signaling Inhibitor Identified in a Multi-Phenotype Profiling Screen in Xenopus Embryos" Chemistry & Biology, Volume 18, Issue 2, 252-263

 

Lab Personnel


Mike Dush, Research Associate, mike_dush@ncsu.edu

Stephanie Bloom, Graduate Student, skbloom@ncsu.edu
Allison Morckel, Graduate Student, armorcke@ncsu.edu
Brooke Griff, Honors Undergraduate Student, bcgriff@ncsu.edu
Leah Marie Snyder, Honors Undergraduate Student, lmsnyder@ncsu.edu