Sherry, Barbara, Ph.D.
Professor of Virology
Phone: (919) 515-4480
Fax: (919) 513-7301
We study reovirus-induced myocarditis (cardiac inflammation and tissue damage) in mice as a model for this important human disease. Recently, we have focused on the cardiac response to viral infection, with particular emphasis on viral induction of the antiviral cytokine interferon-beta in cardiac cells. We are interested in both the viral genes that stimulate this response, and the cardiac transcription factors and antiviral proteins that are central to protection against disease. Our approaches, using primarily molecular techniques, include the use of transgenic mice and primary cardiac myocyte cell cultures. This research is funded primarily by NIH.
Irvin, S.C., J. Zurney, L.S. Ooms, J.D. Chappell, T.S. Dermody, and B Sherry. 2012. A Single Amino Acid Polymorphism in Reovirus Protein µ2 Determines Repression of Interferon Signaling and Modulates Myocarditis. Journal of Virology, 86(4):2302-2311.
Holm, G.H., A.J. Pruijssers, L. Li, P. Danthi, B. Sherry,and T.S. Dermody. 2010. Interferon regulatory factor-3 attenuates reovirus myocarditis and contributes to viral clearance. Journal of Virology, 84(14):6900 – 6908.
Li, L., J.R. Sevinsky, M.D. Rowland, J.L. Bundy, J.L. Stephenson and B. Sherry. 2010. Proteomic analysis reveals virus-specific Hsp25 modulation in cardiac myocytes. Journal of Proteome Research 9(5):2460-2471.
Li, L. and B. Sherry. 2010. IFN-a expression and antiviral effects are subtype- and cell type-specific in the cardiac response to viral infection. Virology 396:59-68.
- This publication was recommended by the Faculty of 1000 in Biology (http://f1000medicine.com/).
Sherry, B. 2009. Reovirus and rotavirus modulation of the interferon response. Journal of Interferon and Cytokine Research 29(9):559-567.
Zurney, J., T. Kobayashi, G.H. Holm, T.S. Dermody, and B. Sherry. 2009. The Reovirus mu2 Protein Inhibits Interferon Signaling Through a Novel Mechanism Involving Nuclear Accumulation of Interferon Regulatory Factor-9. Journal of Virology, 83:2178-2187.
- This publication was selected to be one of that issue's "Spotlights", which are "Articles of Significant Interest Selected from This Issue by the Editors"
Zurney, J., K.E. Howard, and B. Sherry. 2007. Basal expression of IFNAR and Jak-STAT components are determinants of cell type-specific differences in the cardiac antiviral response. Journal of Virology, 81:13668-13680.
- This publication was selected as one of that issue's "Spotlights", which are "Articles of Significant Interest Selected from This Issue by the Editors"
Holm, G.H., J. Zurney, V. Tumilasci, S. Leveille, P. Danthi, J. Hiscott, B. Sherry, and T.S. Dermody. 2007. RIG-I and IPS-1 augment proapoptotic responses following mammalian reovirus infection via IRF-3. The Journal of Biological Chemistry 282(30):21953-61.
O’Donnell, S.M., M.W. Hansberger, J.L. Connolly, J.D. Chappell, M.J. Watson, J.M. Pierce, W. Han, E.S. Barton, J.C. Forrest, T. Valyi-Nagy, F.E. Yull, T.S. Blackwell, J.N. Rottman, B. Sherry, and T.S. Dermody 2005. Organ-specific roles for transcription factor NF-kB in reovirus-induced apoptosis and disease. The Journal of Clinical Investigation 115(9): 2341-2350.
Stewart, M.J., K. Smoak, M.A. Blum, and B Sherry. 2005. Basal and reovirus-induced intereferon-b (IFN-b) and IFN-b-stimulated gene expression are cell type-specific in the cardiac protective response. J. Virology 79(5):2979-2987.
Lance Johnson, Research Associate
Kimberly Parks, Doctoral Student, Functional Genomics graduate program
Efrain Rivera Serrano, Doctoral Student, Comparative Biomedical Sciences graduate program
Rachael Stebbing, Masters Student, Comparative Biomedical Sciences graduate program