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Research Discovery Keeps Lung-cancer Cells from Spreading in Mice

The following article concerns the recently published research of Dr. Kenneth Adler, professor of cell biology in the NC State College of Veterinary Medicine’s Department of Molecular Biomedical Sciences. The article, “Stopping Cancer in its Tracks,” is written by Tracey Peake for the NC State University blog Abstract

We’ve come a long way in cancer treatments – we have powerful, effective drugs for many types of cancer and we’re moving toward ever more specific, less invasive therapies. But the problem with cancer is that it’s always in motion, metastasizing and spreading throughout the body to overwhelm it. What if you could stop cancer in its tracks?

ken adler

Ken Adler, a cell biologist at NC State, may be on to a way to do just that. Adler, who studies cell movement in lung diseases like chronic bronchitis and asthma, developed a peptide, or small protein molecule, that stopped inflammation by inhibiting the movement of inflammatory cells.

(Read editorial in Raleigh News & Observer on Dr. Adler’s research.)

As it turns out, that peptide, called the MANS peptide (for Myristoylated Alanine-Rich N-terminus sequence, if you were wondering), looks like it may also be effective in stopping the movement of other cells, like lung-cancer cells.

In collaboration with a team of scientists from UC Davis including researcher Reen Wu, Adler showed that the MANS peptide stopped lung-cancer cells from moving, or metastasizing, in mice. Their research results appear in the journal Oncogene.

So how, exactly, does a peptide stop a cell from moving?

Adler has spent a very long time looking at a particular protein known as MARCKS (or Myristoylated Alanine-rich C Kinase Substrate) and its involvement in cell movement. When MARCKS is activated, it binds to the cell’s cytoskeleton (the scaffolding inside a cell), and specifically to a protein called actin, which contracts, as well as to the inside of the cell membrane. MARCKS links the actin and the membrane so that actin’s movement translates into cell movement.

MANS works by binding to the membrane at the sites that MARCKS would normally use, crowding MARCKS out. The actin is still doing its job, but the link between the actin and the membrane is broken and the cell stays put.

Adler plans to continue studying the mechanisms that make MARCKS work, as well as the effects of the MANS peptide on metastasis. “Once we get to the basic mechanism of MARCKS, we’ll have a lot of tools at our disposal to use in treating cancer, as well as other diseases,” he says.

For more information:

Full journal article in Oncogene

Article in the News & Observer

Article in the NC State Technician

“Bench to Bedside: the Promise of Translational Research,” article providing background on Dr. Adler’s earlier research with MARCKS protein.

Dr. Adler’s TEDx Raleigh presentation.

 

Posted Sept. 6, 2013