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Ophthalmology

Contact Information

Phone: 919.513.6659
Fax:     919.513.6711
Email:   vhcophthalmology@ncsu.edu
Hours: The Ophthalmology service receives elective cases 9:30AM-3:30PM Monday, Tuesday and Thursday by appointment. We perform elective surgery on Wednesday and Friday. We also make small animal and large animal appointments (through the VHC) twice a month at our satellite clinic at the Equine Health Center in Southern Pines, NC.

The Small Animal and Equine Ophthalmology services are available 24 hours a day, 365 days a year for treatment of emergency problems. To make a referral on an emergency basis, call 919.513.6659 or 919.513.6911. Referring Veterinarians can also call for consults at anytime.

General Information

The Terry Center

red Cross Cadeceus

Emergency Service

Main Number: 919.513.6500
Small Animal Emergency: 919.513.6911
Large Animal Emergency: 919.513.6630
Hours:
Monday-Thursday 5PM-8AM
Friday 5PM-Monday 8AM

Open 24 hours on legal holidays.
No appointment needed.

Laboratory of Ocular Immunology, Toxicology, and Drug Delivery

The goals of this laboratory are to study the mechanisms and treatment of ophthalmic diseases.

Lab Members

Brian Gilger, Principal Investigator
Beth Salmon, Laboratory Supervisor
Kaitlyn Walsh, Ophthalmology Research Scholar

Research

Our laboratory has three main areas of ongoing research:

Ocular Inflammation and Immunology

Ocular Pharmacology, Toxicology, and Drug Delivery

Ocular Imaging

Recent Laboratory Research Abstracts

  1. Gilger BC, Sherman A, Goodell HP, Salmon JH, Velagaleti P, Weiss S, Grau U, Mitra A. Topical pentablock gel ocular retention in New Zealand White Rabbits. Biologics Formulation & Delivery Summit. Boston, MA, May 2014.
  2. Gilger BC. Evaluation of RX-10045 in a post-surgical model of ocular inflammation in rabbits. International Society for Eye Research, San Francisco, CA 2014.
  3. Gilger BC, Salmon JH, Patel SP, Velagaleti PR, Weiss SL, Grau U, Mitra AK. Evaluation of ocular biocompatibility and duration of a bioerodible intravitreal pentablock co-polymer thermosensitive gel and/or nanoparticle ocular drug delivery. Association for Research in Vision and Ophthalmology Annual Meeting, Orlando, FL, May 2014.
  4. Telford, CR, Salmon JH. Gilger BC. Synergistic effect of once daily topical 0.03% bimatoprost and 0.5% timolol maleate on intraocular pressure reduction in normal beagles. Association for Research in Vision and Ophthalmology Annual Meeting, Orlando, FL, May 2014.
  5. Salmon JH, Hirsch M, Borras T, Gilger BC. Validation of gene delivery in sheep ocular models towards a translation strategy for optimization of human eye gene therapy. Association for Research in Vision and Ophthalmology Annual Meeting, Orlando, FL, May 2014.
  6. Barachetti L, Rampazzo A, Mortellaro CM, Scevola S, Gilger BC. Use of episcleral cyclosporine implants in dogs with keratoconjunctivitis sicca. American College of Veterinary Ophthalmologists, November 2013; Puerto Rico.
  7. Nelson N, Gilger BC. SD-OCT corneal and retinal measurements on standing horses. American College of Veterinary Ophthalmologists, November 2013; Puerto Rico.
  8. Gilger BC, Clode AB, Stoppini R, Pinto NH, Hemstead J, Gerding JC, Salmon JH. Treatment of immune mediated keratitis in horses with episcleral cyclosporine matrix implants. International Equine Ophthalmology Consortium Symposium. Jackson Hole, WY, June 2013.
  9. Gilger BC, Pinto NH, Clode AB. Common equine ocular fundus lesions evaluated by SD-OCT. International Equine Ophthalmology Consortium Symposium. Jackson Hole, WY, June 2013.
  10. Gilger BC, Abarca EM, Salmon JH, Patel S. Treatment of posterior uveitis by injection of triamcinolone acetonide into the suprachoroidal space using microneedles. Association for Research in Vision and Ophthalmology Annual Meeting, Seattle, WA, May 2013.
  11. Abarca EM, Potter P, Salmon JH, Gilger BC Characterization and in vitro release profiles of thermogel PLGA-PE-PLGA as a sustained-release of lipophilic drug. Association for Research in Vision and Ophthalmology Annual Meeting, Seattle, WA, May 2013.
  12. Abarca EM, Salmon JH, Gilger BC. Effect of choroidal perfusion on ocular tissue distribution after intravitreal or suprachoroidal injection of fluorescein sodium or lipophilic carbocyanine DiI in an ex vivo porcine eye model. NCSU-UNC Collaborative Studies in Ocular Drug Delivery Workshop, November 13, 2012, McKimmon Center, North Carolina State University, Raleigh, NC.
  13. Hempstead JH, Clode AC, Salmon BH, Gilger BC. Ocular tissue concentration of voriconazole and fluconazole in an ex vivo canine globe perfusion model. NCSU-UNC Collaborative Studies in Ocular Drug Delivery Workshop, November 13, 2012, McKimmon Center, North Carolina State University, Raleigh, NC.
  14. Seiler GS, Feingold S, Dayton PA, Abarca EM, Salmon JH, Gilger BC. Microbubble ultrasound for drug delivery to the posterior segment of the eye using the suprachoroidal space. NCSU-UNC Collaborative Studies in Ocular Drug Delivery Workshop, November 13, 2012, McKimmon Center, North Carolina State University, Raleigh, NC.
  15. Goodell H, Salmon JH, Gilger BC. Perichoroidal drug delivery via magnetically guided nano-pills for macular degeneration. NCSU-UNC Collaborative Studies in Ocular Drug Delivery Workshop, November 13, 2012, McKimmon Center, North Carolina State University, Raleigh, NC.
  16. Abarca EM, Salmon JH, Gilger BC. Effect of choroidal perfusion on ocular tissue distribution after intravitreal or suprachoroidal injection of fluorescein sodium or lipophilic carbocyanine DiI in an ex vivo porcine eye model. American College of Veterinary Ophthalmologists, October 2012; Portland, OR.
  17. Seiler G, Salmon JH, Cartiff SE, Dayton P, Gilger BC. Microbubble delivery of DiI to the ocular posterior segment: comparison of intravitreal and suprachoroidal injection routes. Association for Research in Vision and Ophthalmology Annual Meeting, Ft Lauderdale, FL, May 2012.
  18. Gilger BC, Salmon JH, Wilkie DA, Webb T, Peel M. An aqueous calcineurin inhibitor, SCY-641, is as effective as cyclosporine in the treatment of naturally-occurring keratoconjunctivitis sicca in dogs. Association for Research in Vision and Ophthalmology Annual Meeting, Ft Lauderdale, FL, May 2012.

Recent Laboratory Research Publications

  1. Sherman A, Salmon JH, Goodell HP, Velagaleti P, Weiss S, Grau U, Mitra A, Gilger BC. Topical pentablock gel ocular surface retention in New Zealand White Rabbits. J Ocular Pharm Therap 2014 (in preparation)
  2. Patel SP, Agrahari V, Mitra AK, Salmon JH, Velagaleti P, Weiss S, Grau U, Gilger BC. In vivo ocular tolerability studies of various pentablock copolymer based formulations delivered topically or intravitreally. J Controlled Release 2014 (in preparation).
  3. Gilger BC, Salmon JH, Goodell HP, Velagaleti P, Weiss S. Inhibition of acute post-operative inflammation by RX-10045 in the rabbit paracentesis model. Invest Ophthalmol Vis Sci 2014 (In preparation).
  4. Culp WD, Salmon JH, Gilger BC. A quantitative model of choroidal neovascularization in the rabbit. Exp Eye Research 2014 (in preparation)
  5. Hirsch M, Gilger BC. AAV transduction of the choroid after suprachoroidal injection in the mouse. 2014 (in preparation)
  6. Hempstead JH, Clode AC, Salmon BH, Gilger BC. Ocular tissue concentration of voriconazole and fluconazole in an ex vivo canine globe perfusion model. Vet Ophthalmol 2014 (in preparation).
  7. Pinto NI, Gilger BC. Spectral-domain optical coherence tomography (SD-OCT) evaluation of the cornea, retina, and optic nerve in normal horses Vet Ophthalmol 2014 (In press)
  8. Pinto NI, McMullen RJ, Linder KE, Cullen JM, Gilger BC. Heterochromic iridocyclitis with secondary keratitis (HIK) in adult horses: Clinical, histopathological and immunohistochemical characterization. Vet Ophthalmol 2014 (In press).
  9. Gerding JC, Gilger BC, Clode AB, Montgomery K. Equine orbital fractures: a review of 18 cases (2006 – 2013). Vet Ophthalmol 2014 (In press). (Trainee first author)
  10. Hempstead JH, Clode AC, Salmon BH, Gilger BC. Histopathologic features of equine superficial, nonhealing, corneal ulcers. Vet Ophthalmol 2013; DOI: 10.1111/vop.12117.
  11. Barachetti L, Rampazzo A, Mortellaro, CM, Scevola S, Gilger BC. Use of episcleral cyclosporine implants in dogs with keratoconjunctivitis sicca. Vet Ophthalmol 2014 (In Press).
  12. Gilger BC, Stoppini R, Wilkie DA, Clode AB, Hempstead J, Gerding JC, Salmon JH. Treatment of immune mediated keratitis in horses with episcleral silicone matrix cyclosporine delivery devices. Vet Ophthalmology 2013 DOI:10.1111/vop.12087
  13. Brookshire H, English R, Nadelstein B, Gilger BC. Efficacy of cox-2 inhibitors in controlling inflammation and capsular opacification after phacoemulsification cataract removal. Vet Ophthalmol 2013 (In press).
  14. Abarca EA, Salmon JH, Gilger BC. Effect of choroidal perfusion on ocular tissue distribution after intravitreal or suprachoroidal injection in an ex vivo porcine eye model. J Ocular Pharm Therapeutics 2013 (doi:10.1089/jop.2013.0063).
  15. Gilger BC, Abarca EA, Salmon JH, Patel S. Treatment of posterior uveitis by injection of triamcinolone acetonide into the suprachoroidal space using microneedles. Invest Ophthalmol Vis Sci 2013;54(4):2483-2492.
  16. Gilger BC, Wilkie DA, Salmon JH, Peel MR. A topical aqueous calcineurin inhibitor for the treatment of naturally-occurring keratoconjunctivitis sicca in dogs. Veterinary Ophthalmology 2012; 10; 1-6. DOI:10.1111/j.1463-5224.2012.01056.x
  17. Davis DL, Yi NY, Salmon JH, Charlton AN, Colitz CMH, Gilger BC. Sustained-release celecoxib from incubated acrylic intraocular lenses suppress lens epithelial cell growth in an ex vivo model of posterior capsule opacity (PCO). J Ophthalmol Pharm Therapeutics 2012 Aug;28(4):359-68. (*Gilger corresponding author)
  18. Pate DO, Clode AB, Olivry TM, Cullen JM, Salmon JH, Gilger BC. Immunohistochemical and immunopathologic characterization of superficial stromal immune mediated keratitis in horses. Am J Vet Res 2012;83(7):1069-1073. (Trainee first author)

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