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Ophthalmology

Contact Information

Phone: 919.513.6659
Fax:     919.513.6711
Email:   vhcophthalmology@ncsu.edu
Hours: The Ophthalmology service receives elective cases 9:30AM-3:30PM Monday, Tuesday and Thursday by appointment. We perform elective surgery on Wednesday and Friday. We also make small animal and large animal appointments (through the VHC) twice a month at our satellite clinic at the Equine Health Center in Southern Pines, NC.

The Small Animal and Equine Ophthalmology services are available 24 hours a day, 365 days a year for treatment of emergency problems. To make a referral on an emergency basis, call 919.513.6659 or 919.513.6911. Referring Veterinarians can also call for consults at anytime.

General Information

The Terry Center

red Cross Cadeceus

Emergency Service

Main Number: 919.513.6500
Small Animal Emergency: 919.513.6911
Large Animal Emergency: 919.513.6630
Hours:
Monday-Thursday 5PM-8AM
Friday 5PM-Monday 8AM

Open 24 hours on legal holidays.
No appointment needed.

Ophthalmology
Special Services , Technology & Information

Equine Recurrent Uveitis

Information for the veterinarian and horse owner

Equine recurrent uveitis (ERU), or "moon blindness," is the most common cause of blindness in horses. Studies done at NC State College of Veterinary Medicine and elsewhere have determined that the cause of ERU is an over-reaction of the horse's immune system, which causes inflammation in the eye. Usually this occurs after an initial ocular injury or infection. In most horses, ERU causes episodes of ocular irritation such as corneal cloudiness, pain, discharge, and a small pupil. The episodes usually become more severe and frequent, until the eye becomes blind. Traditional treatment of ERU is usually effective in controlling the active inflammation, but there is no effective way to prevent the recurrent episodes typical of ERU. Because of these problems, we have worked on developing methods to prevent recurrent episodes of uveitis, such as use of sustained release cyclosporine..

Cyclosporine

Cyclosporine is an immunosuppressant drug that is commonly used for treatment to prevent organ transplant rejection and for treatment of dry eyes in dogs. Cyclosporine is the ideal drug to prevent the recurrence of immune-mediated ocular inflammation. It suppresses the activity of the T-lymphocyte, which is the most common infiltrating cell in ERU eyes. However, cyclosporine eyedrops or ointment do not penetrate past the cornea. Therefore it cannot get into the eye to treat the uveitis. Oral cyclosporine would likely be too toxic and expensive to give a horse to prevent ERU.

Sustained-release cyclosporine

eye diagram Studies performed at NC State have shown that reservoir devices placed into the eye can allow long-term (more than 4 years) release of low levels of cyclosporine. Studies have shown that the implants are safe and effective in decreasing inflammation in the equine eye. Clinical studies in horses with ERU have shown excellent control of the disease. However, this is an experimental device and not approved for use in horses by the FDA.

Is my horse a candidate?

The best canidates for the implant are those with the following characteristics:

Your veterinarian's examination will help determine if your horse is a good candidate.

Who can do the surgery?

There are veterinary ophthalmologists in nearly all areas of the US who are or will be trained to perform the implant surgery. Please call us to determine the closest ophthalmologist in your area.

What are the success rates?

This is an experimental procedure, however, long-term results have shown that greater than 80% of horses have ERU controlled. Some horses have lost vision after implantation.

If you are a veterinarian and want to order implants, please click here.

Support us!

Cyclosporine implants have been studied, tested, and manufactured at the Comparative Ophthalmology Research Laboratory at North Carolina State University College of Veterinary Medicine. A large amount of time and money has been spent to develop these devices specifically for the treatment of equine uveitis.

Please support our laboratory and our efforts in the treatment of equine uveitis by donating to the "Equine Uveitis Research Fund" in care of the North Carolina Veterinary Medical Foundation, 1060 William Moore Drive, Box 8401, Raleigh, NC 27607. Telephone 919.513.6660, Fax 919.513.6105.

More on Equine Recurrent Uveitis

Contact

Dr. Brian Gilger
Comparative Ophthalmology Research Laboratory
North Carolina State University
College of Veterinary Medicine
1051 William Moore Drive
Raleigh, NC 27607
Phone: 919.513.6659
Fax: 919.513.6711
Email: VHCophthalmology@ncsu.edu